209 research outputs found
Comparison of the Proliferation and Differentiation Potential of Human Urine-, Placenta Decidua Basalis-, and Bone Marrow-Derived Stem Cells
No full textHuman multipotent stem cell-based therapies have shown remarkable potential in regenerative medicine and tissue engineering applications due to their abilities of self-renewal and differentiation into multiple adult cell types under appropriate conditions. Presently, human multipotent stem cells can be isolated from different sources, but variation among their basic biology can result in suboptimal selection of seed cells in preclinical and clinical research. Thus, the goal of this study was to compare the biological characteristics of multipotent stem cells isolated from human bone marrow, placental decidua basalis, and urine, respectively. First, we found that urine-derived stem cells (USCs) displayed different morphologies compared with other stem cell types. USCs and placenta decidua basalis-derived mesenchymal stem cells (PDB-MSCs) had superior proliferation ability in contrast to bone marrow-derived mesenchymal stem cells (BMSCs); these cells grew to have the highest colony-forming unit (CFU) counts. In phenotypic analysis using flow cytometry, similarity among all stem cell marker expression was found, excluding CD29 and CD105. Regarding stem cell differentiation capability, USCs were observed to have better adipogenic and endothelial abilities as well as vascularization potential compared to BMSCs and PDB-MSCs. As for osteogenic and chondrogenic induction, BMSCs were superior to all three stem cell types. Future therapeutic indications and clinical applications of BMSCs, PDB-MSCs, and USCs should be based on their characteristics, such as growth kinetics and differentiation capabilities
Qualification of the IBM CSC factory in Singapore : resource estimation and allocation in software and hardware services
No full textThesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.Includes bibliographical references.The CSC department of IBM Singapore has been established two years ago. It provides a variety of hardware and software services for its customers. Due to the complex mix of products and the different ways of completing the tasks at each section of the factory, it is difficult to estimate the resources needed to complete a set of similar jobs. It is also difficult to put the resources at the right place at the right time and not create under or overcapacity. A quick way of estimating and allocating resources (qualification) is necessary to predict the cost that will incur for a certain job. This is useful during the negotiation process for a new contract and improves decision making of management. Resource allocation allows smooth workflow within the sections of the factory. This can increase factory capacity. This thesis shows the mistakes made by management during former resource estimation and allocation. It shows the step-by-step examination of the factory operations and the model derived through quantitative and qualitative analysis. It demonstrates the new resource estimation and allocation process and provides thoughts on future areas of development.by Chengguang Li.M.Eng
Development and implementation of a system testing device for microfluidic devices
No full textThe microfluidic industry has seen tremendous growth over the last years and is
expecting further growth in the future. Polymer is the material of choice at the moment
for many applications and is being manufactured into microfluidic devices through
injection molding.
There is no established way of mass producing the mold inserts at the moment. Part of
the research conducted at SMA is aimed to explore options in powder injection molding
as a quick and reliable process to mass produce mold inserts.
During the research phase one needs a way to assess the quality of the new inserts and its
suitability to produce molds and microfluidic devices. This is currently achieved by
manufacturing the final microfluidic parts using the molds and measuring the properties
of these parts using conventional metrology methods at the laboratory. These include
measurements carried out with the optical profilometer and the scanning electron
microscope.Master of Science (Manufacturing Systems and Technology
Meaningful Information Theory
No full textThis paper outlined a theory of meaningful information to explore metaphysical reality and consciousness. It first asserts that there exists a fundamental metaphysical order that can be described mathematically. The core of the theory is triadic nature of meaningful information and their mathematical structure, termed meaningful information monad, which is the fundamental entity at metaphysical depth and scope, as metaphysical reality. The theory could be applied in information science but here those fundamental questions in philosophy and science are focused. It follows both William James’ proposal that the solution of consciousness problem should be in a metaphysical way and Roger Penrose’s proposal that to understand consciousness well needs to understand matter deeper first. The theory can not only repeat the fundamental comprehension of physical world and mathematical world, as essential evidences, but also symmetrically and logically extend to consciousness to unveil its mystery, and further enlighten each other. The results can be compared with current discoveries of sciences including neuroscience and consciousness science. It clearly defined the relations of three worlds and their common foundation. It makes comprehension level of three worlds at same depth and unify them on a deeper foundation in both metaphysical and scientific way. It concludes that consciousness is encoded in the deep nature of metaphysical reality, originated from independence of possible, and its fundamental principle is the translation of structure-possible as one of three translation modes of monad. The theory tries to solve Chalmers’ hard problem and some fundamental easy problems of consciousness. The human being and practice are also natural component of metaphysical reality. The theory can be classified as metaphysical reductionism and holism
How international physical presence and infrastructure differences moderate the link between digital internationalization and MNE performance
No full textHighlights:
• A U-shaped relationship exists between digital internationalization and performance for retail MNEs.
• The U-shape steepens with greater international physical presence and stronger home than host infrastructure.
• Extending the I–R framework to digital and physical domains shows how their interplay shapes performance.
• Managers should pursue hybrid digital–physical strategies to optimize digital internationalization performance.Data availability:
The authors do not have permission to share data.Supplementary data are available online at: https://www.sciencedirect.com/science/article/pii/S0024630126000166#appsec1 .While prior work has predominantly studied the performance implications of multinational enterprise (MNE) physical internationalization, research on how MNEs perform when simultaneously coordinating international digital channels and physical presence remains scarce. This challenge is particularly acute in retail, where the strategic convergence of born-digital retailers expanding physically and traditional retailers going digital creates new cross-domain challenges. Nonetheless, the impact of international physical presence and differences in home country physical infrastructure relative to host countries on MNE performance remains unexplored. Drawing on the integration-responsiveness (IR) framework, we suggest that a non-linear, U-shaped pattern governs the relationship between digital internationalization and performance for these retail MNEs, because the costs of integration and responsiveness are dominant at lower levels of internationalization while their advantages become more pronounced with increased internationalization. Further, we argue that the digital internationalization and MNE performance relationship steepens (a) with a higher international physical presence and (b) for firms originating from home countries with superior physical infrastructure relative to their host countries. Utilizing an 11-year panel of some of the largest retail MNEs, our research contributes to international strategy literature by extending the IR framework to a multidomain digital and physical context, stressing the strategic importance of firm- and country-level physical resources and infrastructure in digital internationalization
SCW corrosion resistance of candidate stainless steels
No full textThe materials selection for Gen IV supercritical water reactor in-core components faces major challenges due to severe operating condition. The current Canadian pressure-tube supercritical water (SCW) concept design requires core outlet temperature of 650°C at 25 MPa with peak cladding temperature reaching as high as 850°C. Aside from other challenges, there is currently very limited data on candidate stainless steels' corrosion resistance under this operating condition. Austenite stainless steels that include 316L, 304H, AL6XN and 310S that cover a wide range of Cr contents are promising candidates for either direct in core applications or as base coating materials. However, their corrosion resistance has not been tested systematically under this stringent condition. In this study, these types of stainless steels are tested, and their corrosion resistances are compared
Meaningful Information Theory Public Files
No full text意识问题与世界根本问题紧密关联，想要彻底回答就必须全部回答。本文阐述一个关于意义信息的理论并用于回答哲学和科学中的一系列根本问题，包括意识问题。理论基于整体世界存在形而上秩序并可数学描述的判断。其核心是意义信息的三重性——信息、可能和结构——及其精确关系结构。这一关系结构称为意义信息单子，是形而上层次的基本单元——形而上实在或终极实在。可理解性原理是认识论第一性原理。从可理解性原理出发获得平移定理。平移是意义信息单子的本征运行模式。物质、意识和精神分别对应三种不同的平移。意义信息单子因此成为物质、意识和精神三个世界共同的形而上实在基础。三个世界构成整体性的具有确定关系的唯一世界。意义信息论可以在形而上层次重述数学、物理学和生命科学的基本概念和原理，并根据其数学结构的意义对称和逻辑伸展把对意识的认知深入到与当前基础科学前沿认知的相同层次并能相互启发。意识被编码在世界整体的运行之中，是世界整体的固有分量和基本属性。意识起源于可能独立，其原理是结构平移，其功能是连接间离性信息并输出可能。自我意识则对应不同结构平移之间的转移。意义信息论根据意义对称原理获得了意识的意义方程，并用于回答意识的困难哲学问题和基础科学问题。意义信息单子具有自上而下和自下而上的双重因果关系属性，并赋予数论以形而上意义。世界以数论为蓝图。
This paper outlined a theory of meaningful information which is fully described in a book. It first proposes that there exists a metaphysical order of the whole world to make exact philosophy possible. The core of the theory is triadic nature of meaningful information and their mathematical structure, called meaningful information monad, which is the fundamental entity as metaphysical reality. It could be applied in information science but here those fundamental questions in philosophy and science are focused. It follows both William James’ proposal that the solution of consciousness problem should be in a
metaphysical way and Roger Penrose’s proposal that to understand consciousness well needs to understand material world deeper first. The theory can not only repeat the fundamental understanding of matter world and mathematics world, as essential intimacy and evidence, but also symmetrically and logically extend to consciousness to disclose its mystery and further enlighten each other. The results can be compared with current discoveries of sciences including neuroscience and consciousness science. It clearly defined the relations of three worlds and their common foundation. It makes understanding
level of three worlds at same depth and unify them on a deeper foundation in both metaphysical and scientific way. It concludes that consciousness is encoded in the deep nature of omniworld, originated from independence of possible, and its fundamental
principle is the translation of structure-possible as one of three translation modes of monad. The theory tried to answer Chalmers’ hard problem and some fundamental easy problems of consciousness. The human being and practice are also natural parts of omniworld. The theory can be classified as metaphysical reductionism and holism
Meaningful Information Theory
No full textThis paper outlined a theory of meaningful information which is fully described in a book. It first proposes that there exists a metaphysical order of the whole world to make exact philosophy possible. The core of the theory is triadic nature of meaningful information and their mathematical structure, called meaningful information monad, which is the fundamental entity as metaphysical reality. It could be applied in information science but here those fundamental questions in philosophy and science are focused. It follows both William James’ proposal that the solution of consciousness problem should be in a metaphysical way and Roger Penrose’s proposal that to understand consciousness well needs to understand material world deeper first. The theory can not only repeat the fundamental understanding of matter world and mathematics world, as essential intimacy and evidence, but also symmetrically and logically extend to consciousness to disclose its mystery and further enlighten each other. The results can be compared with current discoveries of sciences including neuroscience and consciousness science. It clearly defined the relations of three worlds and their common foundation. It makes understanding level of three worlds at same depth and unify them on a deeper foundation in both metaphysical and scientific way. It concludes that consciousness is encoded in the deep nature of omni world, originated from independence of possible, and its fundamental principle is the translation of structure-possible as one of three translation modes of monad. The theory answered Chalmers’ hard problem and some fundamental easy problems of consciousness. The human being and practice are also natural parts of omni world. The theory of meaningful information can be classified as metaphysical reductionism and holism
Meaningful Information Theory Public Files
No full text意识问题与世界根本问题紧密关联，想要彻底回答就必须全部回答。本文阐述一个关于意义信息的理论并用于回答哲学和科学中的一系列根本问题，包括意识问题。理论基于整体世界存在形而上秩序并可数学描述的判断。其核心是意义信息的三重性——信息、可能和结构——及其精确关系结构。这一关系结构称为意义信息单子，是形而上层次的基本单元——形而上实在或终极实在。可理解性原理是认识论第一性原理。从可理解性原理出发获得平移定理。平移是意义信息单子的本征运行模式。物质、意识和精神分别对应三种不同的平移。意义信息单子因此成为物质、意识和精神三个世界共同的形而上实在基础。三个世界构成整体性的具有确定关系的唯一世界。意义信息论可以在形而上层次重述数学、物理学和生命科学的基本概念和原理，并根据其数学结构的意义对称和逻辑伸展把对意识的认知深入到与当前基础科学前沿认知的相同层次并能相互启发。意识被编码在世界整体的运行之中，是世界整体的固有分量和基本属性。意识起源于可能独立，其原理是结构平移，其功能是连接间离性信息并输出可能。自我意识则对应不同结构平移之间的转移。意义信息论根据意义对称原理获得了意识的意义方程，并用于回答意识的困难哲学问题和基础科学问题。意义信息单子具有自上而下和自下而上的双重因果关系属性，并赋予数论以形而上意义。世界以数论为蓝图。
This paper outlined a theory of meaningful information which is fully described in a book. It first proposes that there exists a metaphysical order of the whole world to make exact philosophy possible. The core of the theory is triadic nature of meaningful information and their mathematical structure, called meaningful information monad, which is the fundamental entity as metaphysical reality. It could be applied in information science but here those fundamental questions in philosophy and science are focused. It follows both William James’ proposal that the solution of consciousness problem should be in a
metaphysical way and Roger Penrose’s proposal that to understand consciousness well needs to understand material world deeper first. The theory can not only repeat the fundamental understanding of matter world and mathematics world, as essential intimacy and evidence, but also symmetrically and logically extend to consciousness to disclose its mystery and further enlighten each other. The results can be compared with current discoveries of sciences including neuroscience and consciousness science. It clearly defined the relations of three worlds and their common foundation. It makes understanding
level of three worlds at same depth and unify them on a deeper foundation in both metaphysical and scientific way. It concludes that consciousness is encoded in the deep nature of omniworld, originated from independence of possible, and its fundamental
principle is the translation of structure-possible as one of three translation modes of monad. The theory tried to answer Chalmers’ hard problem and some fundamental easy problems of consciousness. The human being and practice are also natural parts of omniworld. The theory can be classified as metaphysical reductionism and holism
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