1,721,029 research outputs found
Overview of antifungal dosing in invasive candidiasis
No full textIn the past, most antifungal therapy dosing recommendations for invasive candidiasis followed a 'one-size fits all' approach with recommendations for lowering maintenance dosages for some antifungals in the setting of renal or hepatic impairment. A growing body of pharmacokinetic/pharmacodynamic research, however now points to a widespread 'silent epidemic' of antifungal underdosing for invasive candidiasis, especially among critically ill patients or special populations who have altered volume of distribution, protein binding and drug clearance. In this review, we explore how current adult dosing recommendations for antifungal therapy in invasive candidiasis have evolved, and special populations where new approaches to dose optimization or therapeutic drug monitoring may be needed, especially in light of increasing antifungal resistance among Candida spp
Antifungal agents:triazoles
No full textBy the end of the antifungal agents: triazoles chapter, the learner shall be able to:
1. Compare and contrast the main causes of pharmacokinetic variability among
triazole antifungals that could jeopardize the efficacy and/or safety of treatment.
2. Identify specific factors for each triazole antifungal and formulation that may
predispose patients to pharmacokinetic interactions.
3. Describe strategies of how triazole antifungal dosing can be optimized when
inadequate drug exposures are identified by therapeutic drug monitoring
Invasive fungal Infections
No full textUpon completion of the chapter, the reader will be able to:
1. Differentiate epidemiologic differences and host risk factors for acquisition of primary and opportunistic
invasive fungal diseases.
2. Recommend appropriate empiric or targeted antifungal therapy for the treatment of invasive fungal
disease.
3. Describe the components of a monitoring plan to assess effectiveness and adverse effects of
pharmacotherapy for invasive fungal disease.
4. Evaluate the role of antifungal prophylaxis in the prevention of opportunistic fungal diseases
Invasive fungal infections
No full textUpon completion of the chapter, the reader will be able to:
1. Differentiate epidemiologic differences and host risk factors for acquisition of primary and opportunistic
invasive fungal diseases.
2. Recommend appropriate empiric or targeted antifungal therapy for the treatment of invasive fungal
disease.
3. Describe the components of a monitoring plan to assess effectiveness and adverse effects of
pharmacotherapy for invasive fungal disease.
4. Evaluate the role of antifungal prophylaxis in the prevention of opportunistic fungal diseases
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
[Jack Lewis and Steven Lewis Re-Roofing a House]
No full textPhotograph of Jack Lewis and Steven Lewis re-roofing a house in Vidor, Texas. The two men sit on the edge of the roof, smiling for the camera. Various construction materials litter the roof and the ground below. A ladder leans against the side of the house
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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