305,358 research outputs found
E. Droz et H. Lewicka, Le Recueil Trepperel, tome II, Les Farces, 1961
No full textLecoy Félix. E. Droz et H. Lewicka, Le Recueil Trepperel, tome II, Les Farces, 1961. In: Romania, tome 84 n°335, 1963. pp. 413-417
E. Droz et H. Lewicka, Le Recueil Trepperel, tome II, Les Farces, 1961
No full textLecoy Félix. E. Droz et H. Lewicka, Le Recueil Trepperel, tome II, Les Farces, 1961. In: Romania, tome 84 n°335, 1963. pp. 413-417
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, including two distinct V2 subtypes
No full text<p><strong>Research article: The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, including two distinct V2 subtypes</strong></p>
<p>Daniel Ocampo Daza*, Michalina Lewicka¹, Dan Larhammar<br>Department of Neuroscience, Science for Life Laboratory, Uppsala Universitet, Box 593, SE-751 24 Uppsala, Sweden</p>
<p>* Corresponding author. E-mail address: [email protected]<br>¹ Current address: Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden</p>
<p><em>General and Comparative Endocrinology 175(1): 135-143</em><br><em>doi:10.1016/j.ygcen.2011.10.011</em></p>
<p>Accepted October 20, 2011<br>E-pub October 28, 2012<br>Published January 1, 2012</p>
<p>This PDF and Supplementary material corresponds to the article as it appeared upon acceptance.</p>
<p>Cite original work as <em>D. Ocampo Daza, M. Lewicka and D. Larhammar. The oxytocin/vasopressin family has at least five members in the gnathostome lineage, including two distinct V2 subtypes. General and Comparative Endocrinology, 175 (1) (2012) 135-143.</em></p>
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[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Making neurons from stem cells : molecular mechanisms and spider silk substrates
No full textThe understanding of the function of the nervous system and the brain is one of the major intellectual challenges in life sciences. Neurological and psychiatric disorders are in addition major issues for the society, and new approaches are needed to learn more about the brain and to develop new treatments. The development of the mammalian brain is a highly regulated process that involves extra- and intracellular signaling to efficiently regulate gene expression in a precise spatial and temporal manner. The understanding of the differentiation mechanisms into neurons, glia and other cell types in the developing forebrain however is still incomplete. Studies of embryonic telencephalic neural stem cells (NSCs) in vitro may increase the understanding of the molecular mechanisms of brain development, and aid in developing new protocols for defined differentiation of stem cells for clinical use.This thesis is aimed at investigating the mechanisms underlying bone morphogenetic protein(BMP4)-mediated differentiation of NSCs, and to explore the use of recombinant spider silk protein-based matrices in combination with signaling factors, especially BMP4, to generate functional neural cell circuits in vitro. In the first study we discovered that BMP4 treatment of NSCs resulted in a dramatic increase in the expression of the BMP4-inhibitor Noggin. BMP4 mediated non-neural differentiation into mesenchymal cells at low seeding densities, neuronal differentiation at high seeding densities, and astrocyte differentiation in any condition. As the Noggin levels increased linearly at higher densities, we hypothesized that the endogenous Noggin production predominantly mediated an inhibition of mesenchymal differentiation. We further observed that BMP4 stimulation induced an AMPA responsive neuron population at high seeding densities, and that this population was increased by co-stimulation of the signaling factor Wnt3a. By applying whole transcriptome sequencing, we aimed at elucidating the molecular mechanisms responsible for the increased neuronal differentiation by BMP4+Wnt3a. This approach, however revealed an unexpected increase in the expression of genes associated with inhibitory GABAergic neurons, and also functional the expression of the neurogenic bHLH factor Hes6.To apply these novel protocols for differentiation of NSCs into functional neurons, we introduced a novel way of culturing NSCs in substrates generated from recombinant spider silk protein (4RepCT). Spider silk protein is a promising biomaterial due to its biocompatibility, biodegradability, and possibility to use in various forms both in 2D and 3D. NSCs cultured in 2D cultures on 4RepCT “film” structures showed no significant differences in cell proliferation, viability, or differentiation potential compared to control cultures in optimized conditions. 4RepCT substrates generated as “foam” structures could be used for 3D culturing of NSCs, and these NSC cultures differentiated nicely into astrocytes and neurons. Calcium imaging assays revealed that BMP4+Wnt3a-treatment of NSCs grown in 3D4RepCT-matrices resulted in efficient generation of functional excitatory neurons.These studies have thus revealed new molecular mechanisms underlying neural differentiation of cortical stem cells, and point to the versatility of using spider silk protein-based substrates for stem cell cultures. Future studies aim at testing these new concepts in vivo for improved treatment of neurological disease.List of scientific papersI. Andersson T, Duckworth JK, Fritz N, Lewicka M, Södersten E, Uhlén P, Hermanson O. (2011) Noggin and Wnt3a enable BMP-4 dependent differentiation of telencephalic stem cells into GluR-agonist responsive neurons. Mol Cell Neurosci. 47:10-8. https://doi.org/10.1016/j.mcn.2011.01.006 II. Lewicka M, Rebellato P, Uhlén P, Hermanson O. (2013) BMP4-induced neuronal differentiation of cortical stem cells involves a Hes6-dependent GABAergic component. [Manuscript]III. Lewicka M, Hermanson O, Rising AU. (2012) Recombinant spider silk matrices for neural stem cell cultures. Biomaterials. 33:7712-7717. https://doi.org/10.1016/j.biomaterials.2012.07.021 IV. Lewicka M, Rebellato P, Uhlén P, Rising A, Hermanson O. (2013) Building brains in spider webs: Stem cell-derived GluR-agonist responsive neurons grown in 3D matrices of recombinant spider silk protein. [Manuscript]</p
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