1,721,003 research outputs found
CELLULAR EXPRESSION AND TRAFFICKING OF STRESS-INDUCED MOLECULES IN CANCER
Full text linkLe Heat Shock Proteins oltre a ricoprire un ruolo fondamentale nel folding proteico sono considerate dei veri e propri segnali di comunicazione cellulare e la loro interazione con il sistema immunitario è ancora oggetto di studio. ll presente lavoro studia la risposta citoplasmatica e del reticolo endoplasmatico allo stress nei tumori ematologici ed inoltre indaga eventuali vie di comunicazione dello stress a lunga distanza. A tale scopo vengono analizzati i meccanismi di presentazione delle Hsp sulla membrana plasmatica e il loro rilascio, soprattutto attraverso vescicole extracellulari, come gli esosomi. Vengono analizzate la forma citoplasmatica inducibile della famiglia delle HSP70, Hsp72 (HSPA1A), la corrispondente proteina del reticolo endoplasmatico Grp78 ed altre proteine correlate al pathway UPR. Il lavoro è stato eseguito in-vitro utilizzando linee cellulari leucemiche e in-vivo, su campioni da pazienti con sindrome mielodisplastica (MDS). Il lavoro qui presentato dimostra che le cellule presentano in superficie e secernono Hsp72 in maniera diversa in base allo stress subito: in seguito a breve stress la Hsp72 strasloca sulla membrana plasmatica, e viene rilasciata mediante esosomi; dopo stress prolungato la Hsp72 viene secreta attraverso la via endo-lososomiale. Il modello in-vitro ha inoltre dimostrato l'attivazione dell'UPR sotto stress, ma più interessante il modello in-vivo di MDS, una malattia ematologica premaligna, che mostra una up-regolazione della Hsp72 e anche tutte le proteine legate alla via UPR. Gli esosomi purificati da sangue periferico di pazienti con MDS sono in grado di promuovere la differenziazione dei macrofagi e di attivare i linfociti. In conclusione le cellule sono in grado di secernere vescicole extracellulari con diversa composizione e diverse proteine inserite sulla membrana, a seconda delle sollecitazioni applicate: queste vescicole possono essere riconosciute da una varietà di tipi cellulari, e possono innescare risposte differenti ed essere utili sia alle cellule prossime che a quelle lontane e contribuire al mantenimento dell’omeostasi proteica, all’adattamento allo stress e alla modulazione del sistema immunitario
A stamped talisman
Full text linkA large, undated paper talisman belonging to the Nasser D. Khalili Collection was among the most enigmatic objects on display in the exhibition Power and Protection: Islamic Art and the Supernatural (Ashmolean Museum of Art and Archaeology, Oxford, 20 October 2016–15 January 2017). Although unusual, this object is not unique and belongs to a group of documents attested in the late Ottoman world that share several features. First, they are all in the same medium, paper, available in various formats. Second, they all show signs of wear and tear, which are not simply a mark of their age or their support’s fragility but also reflect various forms of physical interaction—from touching, rubbing, and, possibly, kissing, to folding and rolling for storage purposes and easy carrying. Third, they all exhibit an impressive variety of imprinted motifs, featuring texts, images, and diagrams, whose content ranges from the devotional to the magical. The purpose of this article is to establish the context of production of the Khalili talisman through a detailed analysis of its material qualities and content. The broad nature of the texts and images available on it ultimately provides the opportunity to reflect on the limited usefulness of clear-cut categories (e.g., sacred/profane, orthodox/heterodox, religious/folkloric, and Sunni/Shiʿi) when trying to understand and position Islamic material evidence connected to occult practices
Power and protection: Islamic art and the supernatural
Full text linkPower and Protection is an innovative, beautifully illustrated account of the link between artistic production and divinatory practices in pre-modern and early modern Islamic societies An exhibition of the same title will be displayed at ..
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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