103,883 research outputs found
An international survey of daily disposable contact lens prescribing
No full textFree to read\ud
\ud
Purpose\ud
\ud
The aim was to determine the extent of daily disposable contact lens prescribing worldwide and to characterise the associated demographics and fitting patterns.\ud
\ud
Methods\ud
\ud
Up to 1,000 survey forms were sent to contact lens fitters in up to 40 countries between January and March every year for five consecutive years (2007 to 2011). Practitioners were asked to record data relating to the first 10 contact lens fits or refits performed after receiving the survey form. Survey data collected since 1996 were also analysed for seven nations to assess daily disposable lens fitting trends since that time.\ud
\ud
Results\ud
\ud
Data were collected in relation to 97,289 soft lens fits, of which 23,445 (24.1 per cent) were with daily disposable lenses and 73,170 (75.9 per cent) were with reusable lenses. Daily disposable lens prescribing ranged from 0.6 per cent of all soft lenses in Nepal to 66.2 per cent in Qatar. Compared with reusable lens fittings, daily disposable lens fittings can be characterised as follows: older age (30.0 ± 12.5 versus 29.3 ± 12.3 years for reusable lenses); males are over-represented; a greater proportion of new fits versus refits; 85.9 per cent hydrogel; lower proportion of toric and presbyopia designs and a higher proportion of part-time wear. There has been a continuous increase in daily disposable lens prescribing between 1996 and 2011. The proportion of daily disposable lens fits (as a function of all soft lens fits) is positively related to the gross domestic product at purchasing power parity per capita (r2 = 0.55, F = 46.8, p < 0.0001).\ud
\ud
Conclusions\ud
\ud
The greater convenience and other benefits of daily disposable lenses have resulted in this modality capturing significant market share. The contact lens field appears to be heading toward a true single-use-only, disposable lens market
The soft-focus lens and Anglo-American pictorialism
No full textElectronic version excludes illustrations for which permission has not been granted by the rights holderThe history, practice and aesthetic of the soft focus lens in photography is elucidated and developed from its earliest statements of need to the current time with a particular emphasis on its role in the development of the Pictorialist movement. Using William Crawford's concept of photographic 'syntax', the use of the soft focus lens is explored as an example of how technology shapes style.
A detailed study of the soft focus lenses from the earliest forms to the present is presented, enumerating the core properties of pinhole, early experimental and commercial soft focus lenses. This was researched via published texts in period journals, advertising, private correspondence, interviews, and the lenses themselves. The author conducted a wide range of in-studio experiments with both period and contemporary soft focus lenses to evaluate their character and distinct features, as well as to validate source material.
Nodal points of this history and development are explored in the critical debate between the diffuse and sharp photographic image, beginning with the competition between the calotype and daguerreotype. The role of George Davison's The Old Farmstead is presented as well as the invention of the first modern soft focus lens, the Dallmeyer-Bergheim, and its function in the development of the popular Pictorialist lens, the Pinkham & Smith Semi-Achromatic. The trajectory of the soft focus lens is plotted against the Pictorialist movement, noting the correlation betwixt them, and the modern renaissance of soft focus lenses and the diffuse aesthetic.
This thesis presents a unique history of photography modeled around the determining character of technology and the interdependency of syntax, style and art
The Influence of extracellular matrix on lens epithelial cell viability
No full textPosterior capsular opacification is the main complication of cataract surgery and results from the proliferation, migration and differentiation of lens epithelial cells remaining in the capsular bag. To better understand this pathological cell behaviour, 1 investigated the interactions between lens epithelial cells and the bovine lens capsule in vitro and their effect on cell viability. As determined by a colorimetric cell proliferation assay, in vitro culture of cells directly on the bovine lens capsule resulted in maintained cell viability in the presence of staurosporine in both lens epithelial cell lines tested, but in neither of the two non-lens cell lines tested. As determined by immunoblotting and reverse-transcriptase polymerase chain reaction (RT-PCR), cell viability on the bovine lens capsule could further be correlated to the presence of both ɑA-crystallin and αB-crystallin expression. A positive correlation of cell viability on the lens capsule with vimentin and HSP27 expression was also found in a smaller set of cell lines. As determined by gelatin zymography and immunoblotting, MMP-2 was expressed by lens epithelial cells, led to the release of FGF-2 and IGF-1 from the lens capsule and correlated with lens epithelial cell viability. Taken together, these results suggest that the lens capsule can act as a store of releasable growth factors available to the lens epithelial cells, with effects on their protein expression and cell viability
Ultra-wide angle lens design with relative illumination analysis
No full textAn ultra-wide angle lens design with relative illumination analysis is presented. The half field angle of 80°, the relative illumination of the image plane will be reduced. It is necessary to increase the image numerical aperture ratio for X and Y direction, and decrease the angle between the chief ray and optical axis in the image space. However the ultra-wide angle lens induces great barrel distortion causing image extrusion. Therefore, we use F-theta distortion to replace optical distortion. Seven lenses and two pieces of flat glass are used for a sensor 1/6†sensor with 2.1 million pixels. The final result for the lens is a half viewing angle of 80°, F/2.4, a focal length 1.1 mm, a length of 22.37 mm, F-theta distortion of less than 2%, and relative illumination greater than 83%
Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation
No full textBackground: Brahma-related gene 1 (Brg1, also known as Smarca4 and Snf2 beta) encodes an adenosine-5'-triphosphate (ATP)-dependent catalytical subunit of the (switch/sucrose nonfermentable) (SWI/SNF) chromatin remodeling complexes. SWI/SNF complexes are recruited to chromatin through multiple mechanisms, including specific DNA-binding factors (for example, heat shock transcription factor 4 (Hsf4) and paired box gene 6 (Pax6)), chromatin structural proteins (for example, high-mobility group A1 (HMGA1)) and/or acetylated core histones. Previous studies have shown that a single amino acid substitution (K798R) in the Brg1 ATPase domain acts via a dominant-negative (dn) mechanism. Genetic studies have demonstrated that Brg1 is an essential gene for early (that is, prior implantation) mouse embryonic development. Brg1 also controls neural stem cell maintenance, terminal differentiation of multiple cell lineages and organs including the T-cells, glial cells and limbs. Results: To examine the roles of Brg1 in mouse lens development, a dnBrg1 transgenic construct was expressed using the lens-specific alpha A-crystallin promoter in postmitotic lens fiber cells. Morphological studies revealed abnormal lens fiber cell differentiation in transgenic lenses resulting in cataract. Electron microscopic studies showed abnormal lens suture formation and incomplete karyolysis (that is, denucleation) of lens fiber cells. To identify genes regulated by Brg1, RNA expression profiling was performed in embryonic day 15.5 (E15.5) wild-type and dnBrg1 transgenic lenses. In addition, comparisons between differentially expressed genes in dnBrg1 transgenic, Pax6 heterozygous and Hsf4 homozygous lenses identified multiple genes coregulated by Brg1, Hsf4 and Pax6. DNase II beta, a key enzyme required for lens fiber cell denucleation, was found to be downregulated in each of the Pax6, Brg1 and Hsf4 model systems. Lens-specific deletion of Brg1 using conditional gene targeting demonstrated that Brg1 was required for lens fiber cell differentiation, for expression of DNase II beta, for lens fiber cell denucleation and indirectly for retinal development. Conclusions: These studies demonstrate a cell-autonomous role for Brg1 in lens fiber cell terminal differentiation and identified DNase II beta as a potential direct target of SWI/SNF complexes. Brg1 is directly or indirectly involved in processes that degrade lens fiber cell chromatin. The presence of nuclei and other organelles generates scattered light incompatible with the optical requirements for the lens
An f/0.27 High-Gain Lens Antenna for Ultrasmall Platforms at THz Frequencies
No full textThe development of a low focal number and low-mass lens antenna is presented that enables terahertz spectroscopy applications on ultracompact platforms. The antenna operates efficiently over a 20% fractional bandwidth, from 450 to 550 GHz, with a gain of 50 dBi at 500 GHz. The antenna consists of a hyperbolic silicon lens that is placed in a record low focal number configuration (f#=0.27) with respect to an advanced waveguide feed. An incident field-matching analysis is applied to investigate the optimal feed radiation pattern that maximizes the lens aperture efficiency, which would result in a 20% increase in aperture efficiency (> 80%) with respect to a standard open-ended waveguide (< 60% aperture efficiency). A multilayer leaky-wave (LW) stratification is quasi-analytically optimized to approximate the optimal feeding pattern, resulting in a >70% lens aperture efficiency. An example LW stratification is synthesized using silicon micromachining technology and is fully characterized in combination with the dielectric lens. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Tera-Hertz Sensin
An epidemiological assessment of lens opacifications that impaired vision in patients injected with radium-224
No full textThe incidence of lens opacifications that impaired vision (cataract) was analyzed among 831 patients who were injected with known dosages of 224Ra in Germany shortly after World War II. The dependence of the incidence on dosage, i.e., injected activity per unit body weight, and on time after treatment was determined. The observations are equally consistent with proportionality of the incidence of cataract to the square of dosage or with a linear dependence beyond a threshold of 0.5 MBq/kg. The possibility of a linear dependence without threshold was strongly rejected (P less than 0.001). The analysis of temporal dependences yielded a component that was correlated with the injected amount of 224Ra and a component that was uncorrelated. The former was inferred by a maximum likelihood analysis to increase approximately as the square of the time after treatment. The component unrelated to the treatment was found to increase steeply with age and to become dominant within the collective of patients between age 50 and 60. The relative magnitudes of the two components were such that a fraction of 55 to 60% of the total of 58 cataracts had to be ascribed to the dose-related incidence. Impaired vision due to cataract was diagnosed before age 54 in 25 cases. In terms of injected activity per unit body weight no dependence of the sensitivity on age was found; specifically there was no indication of a faster occurrence of the treatment-related cataracts in patients treated at older ages
Zoom lens designs for use in sheet metal cutting by high power CO2-lasers
No full textS.765-776 : Abb.,Tab.,Lit.For best results and highest speed of cutting of sheet metal by high power lasers, the numerical aperture of the focussed beam must be properly matched to the material thickness. To alleviate the need for frequent changes of fixed-focal-length lenses, a zoom lens system, which allows fast and continuous adaption is desirable. Requirements include near difraction limited performance in a range of, at least, f/3 to f/8 and a back focus in excess of the focal length for lens protection against fumes and spatters. Four zoom lens diesgins for use with CO2-lasers in the 1 to 2 kW range are presented which differ in technical complexity (use of an asperic surface versus an additional lens element) and in the ranges of numerical apertures (f/2.8 to f/8 and f/2 to f/7). Only one of these has so far been built and measured, and cutting tests have shown slightly better performance at the short focal lengths over that of single (ZnSe) lenses of (optimized) meniscus shape
The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial
No full textGlaucoma is the leading cause of irreversible blindness. Although primary open-angle glaucoma is more common, primary angle-closure glaucoma (PACG) is more likely to result in irreversible blindness. By 2020, 5·3 million people worldwide will be blind because of PACG. The current standard care for PACG is a stepped approach of a combination of laser iridotomy surgery (to open the drainage angle) and medical treatment (to reduce intraocular pressure). If these treatments fail, glaucoma surgery (eg, trabeculectomy) is indicated. It has been proposed that, because the lens of the eye plays a major role in the mechanisms leading to PACG, early clear lens extraction will improve glaucoma control by opening the drainage angle. This procedure might reduce the need for drugs and glaucoma surgery, maintain good visual acuity, and improve quality of life compared with standard care.EAGLE aims to evaluate whether early lens extraction improves patient-reported, clinical outcomes, and cost-effectiveness, compared with standard care
- …
