1,721,012 research outputs found
More haste, less development speed
Get PDFThe Development Speed Paradox - the observation that increasing development speed by reducing the cycle time of successful molecules INCREASES the expected time to first marketing authorization approval. Conversely, building opportunities to fail unmarketable molecules earlier in the development process - fast-fail strategies - will shorten the time to first marketing authorization approval. By focusing on the small minority of molecules that make it to market, development speed initiatives may sub-optimize the research and development process increasing costs and lowering productivity
The Norm Chronicles: stories and numbers about danger by Michael Blastland and David Spiegelhalter [Book review]
No full textCommunicating health risks in everyday life
Pharmaceutical R&D Productivity: Be Careful What You Wish For
No full textNo one metric is likely to capture an activity as complex, or as uncertain, as R&D. In fact, the pursuit of any one metric to the exclusion of all others is likely to sub-optimize the entire research and development process. This paper outlines the devastating impact that the single minded pursuit of cycle time reduction had on the pharmaceutical industry. Maximising development speed through cycle time reduction clogged the development pipeline with marginal or failing medicines, increased late-stage attrition, increased R&D costs, and paradoxically reduced R&D productivity. The industry became really slick at delivering late-stage failures to the market place
Bad pharma: how drug companies mislead doctors and harm patients by Ben Goldacre
No full textEveryone working in the pharmaceutical industry should read this book. This book catalogues, in detail, with supporting data, how the pharmaceutical industry has distorted the business of evidence-based medicine, despite the best efforts of statisticians in the pharmaceutical industry. You should read this book if for no better reason than that everyone outside of the industry is reading this book
Statistical support to non-clinical
No full textThis paper describes statistical support strategies in clinical and non-clinical areas of pharmaceutical development. The "slash and burn" model of statistical support is introduced. The emphasis on business need rather than regulatory driven support strategies in pharmaceuticals and greater deployment of statistical resource upstream of the clinical process in discovery and preclinical
Should John McEnroe grunt?
No full textThe tennis player John McEnroe is well known for his audible, vocalized \u27grunt\u27 service game. This paper analyzes the outcome of \u27grunt\u27 and \u27silent\u27 serves during the 1983 Wimbledon tennis tournament. Silent serves were twice as successful as grunt serves. Grunt serves were twice as likely to be returned by opponents. Silent serves were more accurate - more likely to be \u27in service\u27 leading to fewer \u27lets\u27 and fewer lost points - and aces were twice as likely to be served on a silent serve as a grunt serve
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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