402 research outputs found
Behind their eyes : identity in the work of Li-Young Lee and Suji Kwock Kim
No full textTHESIS 10818The introduction to this study outlines the theoretical framework for comparing the work of Li-Young Lee and Suji Kwock Kim. Using Walter Mignolo\u27s theories about "border thinking," which he outlined in Local Histories/Global Designs, alongside Anzaldua\u27s Borderlands/La Frontera as a basis for approaching Kim\u27s and Lee\u27s work, I demonstrate how the poets may be considered as embodying the role of border thinkers. Marianne Hirsch\u27s definition of "postmemory," is explored, and its relevance to Kim\u27s and Lee\u27s work established. Short biographies of both poets are outlined. A brief overview of the position of Asian American poetry within Asian American literature is also offered
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells
No full textSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease (COVID-19), is currently infecting millions of people worldwide and is causing drastic changes in people’s lives. Recent studies have shown that neurological symptoms are a major issue for people infected with SARS-CoV-2. However, the mechanism through which the pathological effects emerge is still unclear. Brain endothelial cells (ECs), one of the components of the blood–brain barrier, are a major hurdle for the entry of pathogenic or infectious agents into the brain. They strongly express angiotensin converting enzyme 2 (ACE2) for its normal physiological function, which is also well-known to be an opportunistic receptor for SARS-CoV-2 spike protein, facilitating their entry into host cells. First, we identified rapid internalization of the receptor-binding domain (RBD) S1 domain (S1) and active trimer (Trimer) of SARS-CoV-2 spike protein through ACE2 in brain ECs. Moreover, internalized S1 increased Rab5, an early endosomal marker while Trimer decreased Rab5 in the brain ECs. Similarly, the permeability of transferrin and dextran was increased in S1 treatment but decreased in Trimer, respectively. Furthermore, S1 and Trimer both induced mitochondrial damage including functional deficits in mitochondrial respiration. Overall, this study shows that SARS-CoV-2 itself has toxic effects on the brain ECs including defective molecular delivery and metabolic function, suggesting a potential pathological mechanism to induce neurological signs in the brain
피부 연관 단백질(Keratin 17 Tail과 Erythropoietin)의 구조 기능적 특성 및 영향 연구
No full textskin; 피부;wound healing; 상처 회복;structure; 구조;keratin; 케라틴;erythropoietin; 에리트로포이에틴I. Introduction 1
II. Materials and methods 6
1. In vitro 6
1.1 Plasmids 6
1.2 Protein expression 6
1.3 Inclusion Body (IB) prep 7
1.4 Purification of proteins 7
1.5 Reconstitution of Keratin filament 8
1.6 Assessing keratin filament assemblies and binding 8
1.7 Electron microscope of keratin filaments and measurements of filament width 9
2. In vivo 9
2.1 Cell culture 9
2.2 Sample preparation for skin cell proliferation test 10
2.3 Hematoxylin and eosin (H&E) staining 10
2.4 Western blot 10
2.5 Measurement of the melanin amount 11
3. In slico 12
3.1 Complex structure modeling and analysis 12
4. Statistical analysis 12
III. Results 13
1. The K17 tail domain is essential for filament assembly in the K6/K17 pair 13
1.1 Protein purification for experiment 13
1.2 Sedimentation assay of reconstituted keratin pairs 15
1.3 TEM observations of reconstituted keratin pairs 18
1.4 Self-dimerization of K17T affects keratin filament assembly 19
2. EPO-derived peptides affect skin cell proliferation and melanin synthesis 22
2.1 EPOR is expressed in cells that compose the skin 22
2.2 Designing EPO-derived peptides to reduce side effects and modeling their binding structures to EPOR 23
2.3 Effect of EPO-derived peptides on skin cell proliferation and migration 26
2.4 Effects of EPO-derived peptides on melanin synthesis 31
IV. Discussion 34
1. The K17 tail domain is essential for filament assembly in the K6/K17 pair 34
2. EPO-derived peptides affect skin cell proliferation and melanin synthesis 36
V. Conclusion 37
VI. References 38MasterdCollectio
A Holistic Real-Time Scheduling Framework on Multi-Threaded ROS2 Executors
No full textROS2, Real-time scheduling, Response-time analysis, Resource allocationRobot Operating System (ROS) 2 for robot software development is mainly used in systems where tim-ing constraints exist. A strong timing guarantee should be provided in time- and safety-critical applications. However, ROS2 lacks sufficient real-time support. In this study, we identify existing scheduler problems and design new scheduling behavior for the real-time guarantee of ROS2. Furthermore, we propose a response-time analysis when scheduling is performed using the proposed scheduling method. For real-time support for more tasks, we present a resource allocation method that provides minimal resources under the condition that scheduling is possible. We demonstrate that our proposed framework improves schedulability over existing methods using a case study and simulations of ROS2.|로봇 소프트웨어 개발 프레임워크인 Robot Operating System (ROS) 2는 일반적인 로봇 시스템 뿐만 아니라 자율주행 시스템, 항공 시스템 등의 복잡한 사이버 물리 시스템에서도 널리 사용되고 있다. 이와 같은 시스템은 타이밍 제약이 존재하는 시스템으로, 실시간 지원이 필요하다. 즉, 각 기능의 실행이 데드라인을 넘어서지 않는다는 것을 보장할 수 있어야 한다. 그러나 ROS2는 실시간 지원을 제공해주지 못하고 있다.
따라서 본 논문에서는 ROS2의 실시간 보장을 위한 스케줄링 프레임워크(Holistic Re-al-Time Scheduling Framework)를 제안하였다. ROS2의 기본 스케줄러와 관련 연구의 문제점을 파악하고 개선하여 새로운 스케줄러를 디자인하였다. 기본 스케줄러의 경우 지연시간을 예측할 수 없다는 한계점이 존재하여, 우선순위 기반의 스케줄링을 도입함으로써 예측 가능한 스케줄러를 디자인하였다. 본 논문에서 제안한 스케줄러에 대해 스케줄링 가능성을 판단하기 위하여 응답시간 분석(Response-time analysis)을 진행하였다. 또한 더 많은 태스크에 대해 실시간 지원을 제공해주기 위해 리소스 할당(Resource alloca-tion) 기법을 제안하였다. 마지막으로 실험을 통해 본 연구에서 제시하는 프레임워크가 기존 기법들보다 향상된 scheduling performance를 나타냄을 확인하였다.YⅠ. Introduction 1
Ⅱ. Background 4
2.1 ROS2 Architecture and Communication 4
2.2 ROS2 Scheduling 5
Ⅲ. Limitations of Default Schedulers and Related Work 7
3.1 Limitations of Default Schedulers 7
3.2 Related Work 9
Ⅳ. Real-Time Scheduling for Multi-Threaded Executor 11
4.1 Priority-Driven Scheduling 11
4.2 Improved Scheduling for Multi-Threaded Executor 12
Ⅴ. Response-Time Analysis 14
5.1 System Model 14
5.2 Response-Time Analysis of Multi-Threaded Executor 16
Ⅵ. Resource Allocation 19
6.1 Problem Statement 19
6.2 Resource Allocation for ROS2 20
Ⅶ. Evaluation 22
7.1 Case Study 22
7.2 Schedulability Experiments 24
Ⅷ. Conclusion 28
References 29MasterdCollectio
Anteon koreanum Kim & Lee 2012
No full text16. Anteon koreanum Kim & Lee, 2012 Anteon koreana Kim & Lee, in Kim et al. 2012: 100. TL: Daejeon University (South Korea). Material examined. SOUTH KOREA: 1 ♀, [CN] Daejeon -si, Dong-gu, Daejeon-university, 15–30.VI. 2006 (MT), J.W. Lee (Holotype, YNU); 1 ♀, [GG] Mt. Myeongjisan, Gwimok, Gwimokgogae, 29.VI. 1999, D.H.Hwang (Paratype, YNU); 1 ♀, [GB] Mt. Sodosan, 1000 m, 13–14.VII. 1971, K. Yamagishi leg. (Paratype, ELMU); 1 ♀, [GG] Mt. Taehwasan, Docheog-myeon, Gwangju-si, 219 m, 09– 24.VI. 2007 (MT), J.O. Lim (YNU); 1 ♀, [GW] Hoengseong-gun, Gapcheon-myeon, Hadae-ri, Holocene, 18–23.VI. 2009 (MT), J.W. Lee (YNU); 1 ♀, [GB] Cheongdo-gun, Unmun-myeon, Mt. Unmunsan, Munsuseonwon (U 1), 6–19.Vi. 2008 (MT), J.W. Lee (YNU); 1 ♀, [GG] Mt. Gwanggyosan. Suji-gu, Yongin-si, 26.VI–03.VII. 2008 (MT), J.O. Lim (YNU); 1 ♀, [GG] Mt. Kwanagsan, Manan-gu, Anyang-si, 9–24.VI. 2007 (MT), J.O. Lim (YNU); 1 ♀, [GW] Wongju-si, Heungeommyeon, Maeji-ri, Yeonse Univ., Wonju campus, 26.VI– 19.VII. 2009 (MT), H.Y. Han (YNU); 2 ♀, [GN] Sancheonggun, Samjang-myeon, Yupyeongni, Wangdeungjae, 35 ° 23.08 ’N, 127 ° 46.44 ’E, 16.VI– 20.IX. 2008 (MT), J.W. Lee (1 ♀- MOLC, 1 ♀-YNU); 1 ♀, [GN] Jinju-si, Ibanseong, Daecheon, Gyeongnam For. Env. Res. Inst. 35 °09’N, 128 ° 17 ’E, 43 m, 1–16.IV. 2012 (MT), J.H. Hwang (YNU); P.R. CHINA: 1 ♀, Jilin, Yanbian, Hunchun, N 42 ° 38 ′ 17 ″ E 130 ° 26 ′ 3 ″, 54 m, 21.VII. 2010, J.W. Lee (Paratype, YNU). Hosts. Unknown. Distribution. P.R. China (Jilin), South Korea (Kim et al. 2012). Remarks. The male is unknown. This species is known only in the Eastern Palaearctic: P.R. China (Jilin) and South Korea.Published as part of Kim, Chang-Jun & Lee, Jong-Wook, 2014, Check-list of Anteoninae R. Perkins, 1912 (Hymenoptera: Dryinidae) of South Korea, with description of a new species, pp. 173-192 in Zootaxa 3802 (2) on page 180, DOI: 10.11646/zootaxa.3802.2.2, http://zenodo.org/record/22890
Recent Advances in Flexible and Stretchable Bio‐Electronic Devices Integrated with Nanomaterials
No full textFlexible and stretchable electronics and optoelectronics confi gured in soft, water resistant formats uniquely address seminal challenges in biomedicine. Over the past decade, there has been enormous progress in the materials, designs, and manufacturing processes for fl exible/stretchable system subcomponents, including transistors, amplifi ers, bio-sensors, actuators, light emitting diodes, photodetector arrays, photovoltaics, energy storage elements, and bare die integrated circuits. Nanomaterials prepared using top-down processing approaches and synthesis-based bottom-up methods have helped resolve the intrinsic mechanical mismatch between rigid/
planar devices and soft/curvilinear biological structures, thereby enabling a broad range of non-invasive, minimally invasive, and implantable systems to address challenges in biomedicine. Integration of therapeutic functional nanomaterials with soft bioelectronics demonstrates therapeutics in combination with unconventional diagnostics capabilities. Recent advances in soft materials, devices, and integrated systems are reviewes, with representative examples that highlight the utility of soft bioelectronics for advanced medical diagnostics and therapies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim17117
In Situ Mapping and Local Negative Uptake Behavior of Adsorbates in Individual Pores of Metal-Organic Frameworks
No full textHerein, we report the adsorbate behavior in individual local pores of MIL-101, which is a metalorganic framework (MOF) with two heterogeneous mesopores and different metal sites, by combining adsorbate isotherms and in situ crystallography profiles. The in situ mapping shows that the substrate-adsorbate interaction affects the initial adsorption and pore condensation steps. The monolayer adsorption gradient changes greatly depending on the framework metal-adsorbate attraction force. Also, broad inflection points are found in adsorption isotherms, and the initial shape depends on the different metals. Besides, the capillary condensation at a pore draws adsorbates from other local pores. This leads to the local negative uptake behavior in individual pore isotherms. At higher pressure, they move to a larger space, whereas in a relatively low-pressure range the attraction force between the MOF framework and guest molecule influences the amount of rearranged guest molecules. Furthermore, the origin of the characteristic adsorption behavior based on the metals constituting the MOFs and the relative strength of substrateadsorbate and adsorbateadsorbate interactions are elucidated through the combined study of electron densities in pores, electron paramagnetic resonance spectroscopy spectra, and density functional theory and Monte Carlo simulations to uncover the previously veiled information on adsorption behavior.
Synthesis of an ionic polyacetylene derivative via phosphorus oxychloride-activated polymerization of 2-ethynylpyridine
No full textA new ionic polyacetylene was synthesized via the non-catalyst polymerization of 2-ethynylpyridine using phosphorus oxychloride. The polymerization proceeded well in homogeneous manner to give a moderate yield of polymer (74%). The resulting polymer was completely soluble in polar organic solvents including water. The photoluminescence spectrum showed the two maximum peaks of 471nm and 489nm corresponding to the photon energy of 2.64eV and 2.54eV, respectively. The oxidation and reduction onset potentials of polymer were observed at 970 and -130mV, respectively.
Transparent and stretchable interactive human machine interface based on patterned graphene heterostructures
No full textAn interactive human-machine interface (iHMI) enables humans to control
hardware and collect feedback information. In particular, wearable iHMI
systems have attracted tremendous attention owing to their potential for use
in personal mobile electronics and the Internet of Things. Although signifi -
cant progress has been made in the development of iHMI systems, those
based on rigid electronics have constraints in terms of wearability, comfortability,
signal-to-noise ratio (SNR), and aesthetics. Herein the fabrication of a
transparent and stretchable iHMI system composed of wearable mechanical
sensors and stimulators is reported. The ultrathin and lightweight design
of the system allows superior wearability and high SNR. The use of conductive/
piezoelectric graphene heterostructures, which consist of poly( L -lactic
acid), single-walled carbon nanotubes, and silver nanowires, results in high
transparency, excellent performance, and low power consumption as well
as mechanical deformability. The control of a robot arm for various motions
and the feedback stimulation upon successful executions of commands are
demonstrated using the wearable iHMI system.11311381sciescopu
Epyris dulicus Lim et S. Lee, sp. nov.
No full text13. Epyris dulicus Lim et S. Lee, sp. nov. (Figs 133–139) Type material. Holotype Ƥ, Korea: Mt. Gwanggyosan, Suji-gu, Yongin-si, GG, 37 ° 19 ' 56.8 "N 127 °02' 37.8 "E, 214 m, MT, 21–30.V. 2008, J. Lim leg. Paratypes: 2 Ƥ, Donam-ri, Banpo-myeon, Gongju-si, CN, MT, 16.V– 6.VI. 2007, MT, Y. Kim leg. Diagnosis. This species is similar to E. tennyo Terayama 2006 by having antenna testaceous except basal three fourths of scape black; head and pronotal disc microreticulate with moderately punctuate; fore wing with small metacarpus; propodeal disc with median and pair of submedian carinae. However, this new species has mandible with two teeth; clypeus long and anteriorly truncate; punctures of head and mesosoma separated from each other by 2.0– 2.5 × as its maximum diameter; whereas E. tennyo has mandible with one tooth; clypeus short and obtuse anteriorly; punctures of head and mesosoma separated from each other by 3.0–5.0 × as its maximum diameter. Description. FEMALE (holotype). Body length 4.9 mm (Fig. 133); LFW 2.6 mm. Color. Body black; mandible dark castaneous; antenna dark castaneous except basal two thirds of scape black; fore wing subhyaline, veins castaneous; legs light castaneous except coxa and femora black. Head (Figs 134, 135, 137). Polished, 1.1 × as long as wide. Vertex slightly convex with rounded corners. Temple profile divergent anterad. Frons almost polished, punctures somewhat strong, each puncture separated from each other by 2.0– 2.5 × as its maximum diameter (Fig. 135). Mandible with truncate two teeth, upper tooth large, about 2.0 × as lower tooth (Fig. 137). Clypeus with well projected trapezoidal median lobe. First five antennal segments in ratio of 3.2: 1.4: 1.0: 1.4: 1.3 in length; from scape to flagellomere 3 and 11 2.2, 1.6, 1.0, 1.5, 1.4 and 1.8 × as long as wide, respectively (Fig. 134). Eye 0.39 mm long with short erect hairs. HE 1.0 × OOL; WF 3.0 × WOT. Frontal angle of ocellar triangle right, POL 1.1 × AOL; OOL 2.0 × WOT (Fig. 135). Mesosoma (Figs 136, 139). Pronotum coriaceous, punctate as head, 0.7 × as long as wide, posterior margin concave. Mesoscutum coriaceous, punctate as head and pronotum. Notauli divergent anterad. Scutellar disc coriaceous and coriaceous and punctate as head and pronotum, connected with anterior margin of propodeum, scutellar pit oval, each pit separated from each other by 2.5 × as its maximum diameter (Fig. 136). Propodeal disc polished, 0.9 × as long as wide with posterior margin straight and lateral margin parallel in dorsal view, three discal carinae present, median discal carina reaching posterior carina, submedian discal carinae reaching 0.8 × of disc length, median area regulose, sublateral area strigate and rugulose; propodeal declivity coriaceous with median longitudinal carina (Fig. 139), lateral surface of propodeum coriaceous. Fore wing with short metacarpus, 0.2 × as long as pterostigma. Metasoma (Fig. 138). Petiolate and polished with very fine punctures and few hairs. MALE. Unknown. Distribution. Korea (CN, GG). Etymology. The specific name is an aleatory combimation of letters with ending - us.Published as part of Lim, Jongok, Lee, Jongwook, Koh, Sanghyun, Lee, Bongwoo, Azevedo, Celso O. & Lee, Seunghwan, 2011, Taxonomy of Epyris Westwood (Hymenoptera: Bethylidae) from Korea, with the descriptions of ten new species, pp. 1-38 in Zootaxa 2866 on pages 25-27, DOI: 10.5281/zenodo.27743
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