1,721,081 research outputs found
A Plastform of Surface-Enhanced Raman Scattering for Photonic PCR using Plasmonic Nanopillar Arrays
No full text
Configurable 3D Nanoscale High Aspect Ratio Pillars for Surface-Enhanced Raman Spectroscopy
No full text
Surface-enhanced Raman spectroscopy based ultrafast DNA assays using photothermal PCR chip with plasmonic nanopillar arrays
No full textAn amplification and SERS-based quantification of genetic molecules have been demonstrated for ultrafast DNA assays using photothermal PCR chip with plasmonic nanopillar arrays. Glass nanopillar arrays with gold nanoislands have multiple roles of plasmonic heat generator using photothermal effect as well as SERS substrate using local field enhancement. The photothermal heating by plasmonic nanopillar arrays on LED enables a ultrafast rate of thermal change with highly efficient amplification and the nanogap-rich structure supports a significant increase of SERS peak for conjugation between SYBR green and amplicon with low cycle threshold. This novel method can open up for improved point-of-care molecular diagnosis
Continuous differential impedance spectroscopy of single cells
Full text linkA device for continuous differential impedance analysis of single cells held by a hydrodynamic cell trapping is presented. Measurements are accomplished by recording the current from two closely-situated electrode pairs, one empty (reference) and one containing a cell. We demonstrate time-dependent measurement of single cell impedance produced in response to dynamic chemical perturbations. First, the system is used to assay the response of HeLa cells to the effects of the surfactant Tween, which reduces the impedance of the trapped cells in a concentration dependent way and is interpreted as gradual lysis of the cell membrane. Second, the effects of the bacterial pore-forming toxin, Streptolysin-O are measured: a transient exponential decay in the impedance is recorded as the cell membrane becomes increasingly permeable. The decay time constant is inversely proportional to toxin concentration (482, 150, and 30 s for 0.1, 1, and 10 kU/ml, respectively)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Batch Fabrication of Nanopillars for Autonomous Nanofluidic SERS Arrays
No full textResearch was supported by DARPA. One of the authors(MSP) was supported by th (DOD) National Defense Science and Engineering Graduate Fellowshi
- …
