7,610 research outputs found
Neonatal fluoxetine exposure affects the neuronal structure in the somatosensory cortex and somatosensory-related behaviors in adolescent rats.
No full textAltered parcellation of neocortical somatosensory maps in N-methyl-D-aspartate receptor-deficient mice.
No full textAngela Lee: The Stakes in Steak
No full textJoin Charlotte and Angela Lee, Assistant Professor at Ryerson University\u27s Faculty of Law, as they discuss her paper in the DLJ, The Stakes in Steak: Examining Barriers to and Opportunities for Alternatives to Animal Products in Canada
Angela explains the broad importance of food and food law around the world, the links between food systems and the environment, and the regulatory barriers to alternative meat products in Canada.
You can read Angela\u27s article here: Angela Lee, The Stakes in Steak: Examining Barriers to and Opportunities for Alternatives to Animal Products in Canada (2018) 41:1 Dal LJ 219
Telithromycin and quinupristin-dalfopristin resistance in clinical isolates of Streptococcus pyogenes: SMART Program 2001 data
No full textThe zeroth order solution of the velocity field around micro comb structures with lateral oscillation
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CURE ANALYSIS OF SHEET MOLDING COMPOUND IN MOLDS WITH SUBSTRUCTURES
No full textThis work is supported by the National Science Foundation sponsored
Engineering Research Center for Net Shape Manufacturing. The authors
would also like to thank the financial support from General Motors, Union
Cabide, Gencrop, and Ashland Chemical companies. Material donations from
Ashland Chemical is greatly appreciated
FLOW-ANALYSIS OF SHEET MOLDING COMPOUNDS IN COMPRESSION MOLDING
No full textA series of experiments and a numerical simulation were carried out to investigate the flow of silly putty and sheet molding compound (SMC) at various processing conditions in compression molding. The flow resistance and the interface friction of both materials were characterized by using a squeeze flow rheometer and the ring compression test, respectively. Molding experiments were carried out on an instrumented mold and the finite element code ALPID (Analysis of Large Plastic Incremental Deformation) was used for numerical simulation. The flow front shape, temperature profile, and pressure change obtained by numerical simulation compared well with experimental results
Determination and validation of LJ-2698, a potent human A3 adenosine receptor antagonist, in rat plasma by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study
No full textLJ-2698, a highly potent human A(3) adenosine receptor antagonist with nucleoside structure, was designed to have a minimal species dependence. For further pre-clinical studies, analytical method for the detection of LJ-2698 in rat plasma was developed by liquid chromatography-tandem mass. Plasma samples were processed by protein precipitation method with acetonitrile, using losartan as the internal standard (IS). Chromatographic separation was carried out using a Kinetex C18 column (100 x 4.6 mm; 100 angstrom; 2.6 mu) with acetonitrile/water with 0.2% (v/v) formic acid (65:35, v/v) in the isocratic mode at a flow rate of 0.4 mL/min. Mass spectrometric detection in multiple reaction monitoring mode was performed with positive electrospray ionization. The mass transitions of LJ-2698 and IS were m/z 412.3 -> 294.1 and m/z 423.1 -> 207.2, respectively. The calibration curves were linear in the range 5.00-5000 ng/mL (r (2) >= 0.998). The lower limit of quantification was established as 5.00 ng/mL. Within- and between-run precisions were < 7.01%, as relative standard deviation; and accuracies were in the range 3.37-3.64%, as relative error. The validated method was successfully applied to its pharmacokinetic evaluation after intravenous and oral administration in rats, and the dose-dependent pharmacokinetic behavior of LJ-2698 was elucidated for the first time.N
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