88 research outputs found
The Relationship Between Market Culture, Clan Culture, Benevolent Leadership, Work Engagement, and Job Performance: Leader's Dark Triad as a Moderator.
No full textLee, M C C., Ding, A Y L., “The Relationship Between Market Culture, Clan Culture, Benevolent Leadership, Work Engagement, and Job Performance: Leader's Dark Triad as a Moderator.” Published in “Psychological Reports” Pages 1-25, August 18, 2022.
http://dx.doi.org/10.1177/00332941221121564Benevolent leadership is one of the leadership styles which provides a positive influence on employees. However, the current leadership literature has yet to investigate how benevolent leadership leads to job performance, the processes involved, the relationship between organizational culture and benevolent leadership, and the role of dark side of leaders in affecting this relationship. Using the leader-culture fit framework within an Eastern context, the current study first investigates the relationship between benevolent leadership and job performance through work engagement. The study then compares two contrasting organizational culture (i.e., market culture and clan culture) on benevolent leadership. Finally, the study investigates how leaders' dark triad affects the relationship between organizational culture and benevolent leadership. 374 full-time white-collar employees (Males = 54.01%; Mean age: 32.7 years) from various private organizations within the service industry participated in this study. The results showed that work engagement mediated benevolent leadership and job performance. Market culture showed a negative relationship with benevolent leadership while clan culture showed a positive relationship with benevolent leadership. Benevolent leadership mediated clan culture (but not market culture) and work engagement. Under a high market culture with a high dark triad leader, benevolent leadership is at its lowest level. Under a high clan culture with a low dark triad leader, benevolent leadership is at its highest level. The findings suggest the importance of benevolent leadership within a clan culture (rather than market culture), in aligning with the leader-culture fit framework in increasing employees' work engagement and job performance.Published onlin
Heterodimeric vascular endothelial growth factor and use thereof
No full text[[abstract]]A fusion protein, comprising: (i) a first vascular endothelial growth factor (VEGF) isoform, and (ii) a second VEGF isoform, and (iii) a dimerization domain between the first isoform and the second isoform, wherein the first isoform and the second isofor
Students' understanding of geometric properties experienced in a dynamic geometry environment
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Lon restrains apoptosis via sequestering p53 in mitochondria under oxidative stress
No full text[[abstract]]Lon is a mitochondrial matrix protease that assists protein folding, degrades oxidized/damaged proteins. Lon overexpression promotes cell apoptotic resistance to stresses, and transformation. However, little literature undertakes detailed investigations on how Lon regulates apoptosis. Accumulating evidences indicate that the stress signals also induce transportation of p53 to mitochondria, leading to induction of apoptosis in a transcription-independent manner. Here, we found that overexpression of Lon increases p53 expression and knockdown of Lon reverses the effects in oral cancer cell lines. We observed that Lon interactes with p53 in mitochondrial and traps p53 to restrain the apoptosis induced by oxidative stress, suggesting that Lon overexpression inhibits apoptosis through interaction with and sequestering p53 in mitochondria. Indeed, the mRNA expression of p53 target genes is significantly reduced when overexpressed Lon traps p53 in mitochondria. In addition, the ATPase mutant of Lon decreases the interaction with p53 and fails to inhibit apoptosis. These findings suggest that targeting mitochondrial Lon will increase the efficacy of p53-induced apoptosis in cancer therapy
Heterodimeric vascular endothelial growth factor and use thereof
No full text[[abstract]]A fusion protein, comprising: (i) a first vascular endothelial growth factor (VEGF) isoform, and (ii) a second VEGF isoform, and (iii) a dimerization domain between th
The evolution of research activity in Spain. The impact of the National Commission for the Evaluation of Research Activity (CNEAI)
Full text linkThis article outlines the evolution of international scientific production in Spain over the last 25 years, a period characterised by steady growth in research production. The following stages in this process are identified in accordance with some of the factors that predominated at different times. From 1974 to 1982 production increased due to causes endogenous to the scientific system itself, as scientists brought their work into line with the patterns which characterised research in other industrialised countries. From 1982 to 1991 the prioritisation of R&D by government administrative bodies represented a constant stimulus, implemented through a set of legal measures, investments and the creation of posts for new researchers. From 1989 to the present the creation of the Comisión Nacional de Evaluación de la Actividad Investigadora (National Commission for the Evaluation of Research Activity, CNEAI) and the research incentive system have provided a further stimulus, which has led to the maintenance of, and an increase in, the rate of research production in spite of the net decrease in the monetary value of research grants awarded during the last period analysed. Other special characteristics of Spanish research, such as its dependence on the public sector and its essentially academic nature, are discussed
Lon-ROS axis induces mtDNA release that activate cGAS-STING-IFN signaling and pack in exosome in tumor microenvironment
No full text[[abstract]]Mitochondrial Lon functions in protein quality control and stress response pathways in mammals. Lon also has been shown to be overexpressed in various types of cancer including colon cancer, prostate cancer and oral cancer. Recently, we observed that Lon overexpression promotes ROS-dependent NF-κB and interferon (IFN) signaling in oral cancer, suggesting that Lon may induce a NF-κB-dependent inflammatory response. Herein, we used microarray expression analysis to demonstrate that Lon overexpression induces the interferon-stimulated genes, such as ISG15, IRF7 and STAT1 in a ROS-dependent manner in OSCC. We further found that mitochondrial DNA is released into cytosol in the Lon-overexpressing oral cancer cells and Lon-ROS axis induced the cGAS-STING pathway, then the mtDNA transfers to extracellular space by exosomes. In addition, we observed that Lon overexpression induces the ROS-dependent expression of indoleamine 2,3 dioxygenase (IDO) in OSCC, which is involved in mtDNA-STING activation tumor tolerogenic response. Taken together, these results suggest that inflammation induced by Lon overexpression may have an immunosuppression effect on tumor microenvironment
Comparing empowering, transformational, and transactional leadership on supervisory coaching and job performance: A multilevel perspective
Full text linkCaul read and publishWith a leader being able to possess different types of leadership styles, there is a lack of literature investigating which leadership style best facilitates supervisory coaching behavior. The current study aimed to investigate which leadership style would exhibit supervisory coaching behavior, and if supervisory coaching behavior would mediate the relationship between leadership styles and job performance. The study compared the effects of three leadership styles-transformational, transactional, and empowering leadership-on supervisory coaching behavior, which has been reported to influence job performance. A multilevel approach was adopted in this study using 500 employees from 65 organizations within Malaysia. The study found that only empowering and transactional leadership styles exhibited supervisory coaching behavior, which in turn mediated their relationships with job performance. Overall, the findings suggest the importance of leadership styles that prioritize employee development, as these would lead to improved job performance in employees.Publishe
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