1,721,327 research outputs found
Strategic Environmental Assessment and Landscape Master Planning: First Evidence from an on-line Survey in Sardinia
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Giant cell arteritis and innovative treatments
Full text linkPurpose of reviewGiant cell arteritis (GCA) is an idiopathic and persistent condition characterized by granulomatous vasculitis of the medium and large vessels with overlapping phenotypes, including conventional cranial arteritis and extra-cranial GCA, also known as large-vessel GCA. Vascular problems linked with large vessel involvement may partly be caused by delayed diagnosis, emphasizing the necessity of early detection and the fast beginning of appropriate therapy. Glucocorticoids are the cornerstone of treatment for GCA, but using them for an extended period has numerous, often severe, side effects.Recent findingsclinical practice and novel discoveries on the pathogenic pathways suggest that steroid-free biologic treatments may be efficient and safe for GCA patients.Summarysince now, only Tocilizumab is approved for GCA treatment, but several drugs are currently used, and ongoing trials could give both researchers and patients novel therapeutic strategies for induction, maintenance, and prevention of relapse of GCA. The aims of this work is to synthesize evidence from current studies present in scientific literature about innovative treatment of Giant cell artheritis
State of the art: the treatment of systemic lupus erythematosus
Full text linkPurpose of reviewSystemic lupus erythematosus (SLE) is a systemic autoimmune disease with dysregulated cells in the immune system. The disease affects organs like kidneys, nervous system, joints, and skin. To manage SLE effectively, novel treatments targeting immune system components have been developed. This review investigates the therapeutic potential of existing targeted therapies and explores future innovative approaches for well tolerated, personalized treatment.Recent findingsSLE treatment involves cytokine targets and specific immunologic pathways, with even small molecules involved.SummaryThe advanced therapeutic options in SLE management give clinicians more tools to control disease activity according to personalized medicine
Situacion en Italia del recuento de cèlulas somaticas en la leche de oveja y estrategias de control.
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A semiring-like representation of lattice pseudoeffect algebras
No full textIn order to represent lattice pseudoeffect algebras, a non-commutative generalization of lattice effect algebras, in terms of a particular subclass of near semirings, we introduce in this article the notion of near pseudoeffect semiring. Taking advantage of this characterization, in the second part of the present work, we present, as an application, an alternative, rather straight as well as simple, explanation of the relationship between lattice pseudoeffect algebras and pseudo-MV algebras by means of a simplified axiomatization of generalized Łukasiewicz semirings, a variety of non-commutative semirings equipped with two antitone unary operations
Overcoming implementation barriers: A method for designing Strategic Environmental Assessment guidelines
Full text linkStrategic Environmental Assessment (SEA) has been officially introduced in the European Union by the Directive 2001/42/EC (Directive) as a decision support system to ensure environmental and sustainable policies in plan and program making. According to the Directive, SEA should be integrated in and inform planning processes from the early stages, in order to obtain an effective consideration of the environmental concerns.
European member states have acknowledged the SEA Directive at different stages through diverse legislative acts. This rather new legislative scenario and the correct application of SEA is still limited and needs to be steered through the dissemination of proper documents, beyond the usual emulation of best practices. In this vein, administrative bodies in charge of SEA management have issued guidelines and manuals in order to address the major difficulties that hinder SEA implementation in the day-to-day practice.
This study proposes a methodology that assists responsible agencies and professionals in the design of SEA guidance documents. The proposed methodology uses a comparative approach which builds on the key elements of those documents. We have applied our methodology at European national level and evaluated principles, contents, and effectiveness of those guidelines. Our work is intended to support government agencies as well as practitioners in the design and update of SEA guidelines in a variety of cases, as the general principles that we outline can be applied to any program and plan subject to SEA
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