1,721,070 research outputs found
Chirol, Y., Jasovic, Z., Lazarevic, D., Maroszek, B., Peyre, V., Szabo, A. - Délinquance juvénile et développement socio-économique
No full textPoitou Danielle. Chirol, Y., Jasovic, Z., Lazarevic, D., Maroszek, B., Peyre, V., Szabo, A. - Délinquance juvénile et développement socio-économique. In: Cahiers d'études africaines, vol. 21, n°81-83, 1981. Villes africaines au microscope. pp. 434-435
Omics Sciences in Drug Discovery, Safety, and Pharmacokinetics
No full textOmics sciences study the whole complex of a specific type of biological molecules within an organism, be it DNA (genomics), RNA (transcriptomics) to the entire class of proteins (proteomics), including also the regulatory primary or secondary modifications of DNA sequence or topological organization (epigenomic), and cellular metabolites (metabolomics). The application of these approaches to the study of pharmacology, more specifically to drug discovery and pharmacokinetics, have greatly impacted these fields, leading to important benefits for patients, bringing to life new compounds and preventing the emergence of life-threatening side effects in patients. Recent developments are ushering a new era for the application of omics techniques in pharmacology. In this chapter, we describe state-of-theart technologies based on sequencing or array platforms which proved useful for pharmacogenomics and safety studies. Finally, we provide our perspective on the current challenges and further promising developments in the (multi)omics characterization and data integration toward a better identification and use of drugs in human health
The role of Design as a barrier to and enabler of the Circular Economy
Full text linkThe development of a Circular Economy (CE) for products is being encouraged to reduce waste and conserve resources. Development is currently limited however and some research discovered that business and policy makers see the main barriers are cultural and market-based and lack of legislation rather than technological / design based. ‘Design’ is doing or planning something with a specific purpose in mind and therefore designed artefacts, services, systems and strategies can be transformative. In this chapter we discuss the role and importance of design as both a barrier to and an enabler of the Circular Economy and propose that design and technology are equally as important as social and financial factors. We consider the power of Design and its influence on Linear and Circular Economies in general and then with specific reference to three real world case studies; we also discuss the impact of different technologies on Circular practice and conclude that the Circular Economy is dependent on the integration of design, technology, social and economic criteria.
This is a draft chapter. The final version will be available in Handbook of the Circular Economy edited by Brandão, M., Lazarevic, D., Finnveden, G, forthcoming 2020, Edward Elgar Publishing Ltd. The material cannot be used for any other purpose without further permission of the publisher, and is for private use only
A novel p53 inducible gene coding for a microtubule-localized protein with G2 phase-specific expression
No full textDismantling cell-cell contacts during apoptosis is copuled to a caspase dependent proteolyitic cleavage of beta-catenin
No full textA novel p53-inducible gene encoding for a microtubule-localised protein with G2-specific expression
No full textEditorial special issue who will benefit from the transition to the circular economy?
No full textOver the last two decades, the enormous impact of the take-makewaste linear economic model has pushed the academic research
(Uphadhayay et al., 2024; Anaruma et al., 2022; Schoggl ̈ et al., 2020;
Ghisellini et al., 2016; Su et al., 2013) and stakeholders of worldwide
socio-economic systems (such as policy makers, consumers, non-profit
organizations, media) to focus their attention towards the development and adoption of consumption and production models oriented
towards the Circular Economy paradigm (Ellen Mac Arthur Foundation,
2024). Societal stakeholders have been increasingly involved in programs, policies, and strategies aimed at transitioning towards CE (Clube
and Tennant, 2023; Van Bueren et al., 2023). Consequently, the Circular
Economy is gaining momentum (Kirchherr et al., 2023) and is attracting
much of the debate on the search for sustainable solutions (Evans, 2023;
De Lima, 2022; Terra dos Santos et al., 2022) to support the diffusion of
consumption (Shevchenko et al., 2023) and production patterns with
lower impacts on resources leveraging longer lifetimes for enhanced
environmental conservation (Luzzati et al., 2022) and socially just
(Costanza, 2023; D’Urzo and Campagnaro, 2023; Persson and Hinton,
2023; Pitkanen ̈ et al., 2023; Vanhuyse et al., 2022) and cost-effective
waste management supply chains (Zerbino et al., 2023) and systems
(Harala et al., 2022).
Countries are adopting CE strategies, programmes and policies
(Guarnieri et al., 2023; Rebehy et al., 2023; Remme and Jackson, 2023;
Lazarevic et al., 2022) and integrating CE in their sustainability agendas
(Pynol Alberich et al., 2023) even if in a diversified manner, both in EU
(such as between Northern-Western and Southern-Eastern states and
regions) (Awad, 2023; Arsova et al., 2022; Van Langen and Passaro,
2021) and non-EU countries such as Brazil (Guarnieri et al., 2023;
Rebehy et al., 2023) and China (Agutiono et al., 2023; Wang et al.,
2022). Furthermore, consumers/citizens are becoming more aware of
the CE concept and its potential in relation to climate change (Eurobarometer, 2023) and more environmentally responsible in their daily
life (Greene et al., 2024) but showing a resistance to radically change
their consumption habits (Bigliardi et al., 2022).
In terms of physical material flows the adoption of the CE model is
still at the early stage in the worldwide economy since the circularity
rate is only 7.2% (Circular Economy Foundation, 2024), although some
EU countries (e.g. Netherlands and Belgium) have achieved a higher
circularity rate and are able to send back to the economy more than 20%
of the recovered materials (EUROSTAT, 2023). Therefore, it is important
to understand at this initial stage the CE potential of contributing to
mitigate climate change and natural resources consumption (Ghisellini
et al., 2023) but also of pursuing a more sustainable human development
(Clube and Tennant, 2023; Nogueira et al., 2023; Tiep Le, 2022) and
reduce the injustices of the linear model of production and consumption
(Persson and Hinton, 2023; Pitkanen ̈ et al., 2023; Velancia et al., 2023;
Vanhuyse et al., 2022). In other terms, this SI intends to understand
more broadly who the beneficiaries of the CE are.
Particular attention has been dedicated to encouraging the analysis
of the environmental and social impacts and benefits resulting from CE
implementation from a large perspective across R principles beyond
recycling, policy programmes, research projects, methods, scales (micro,
meso, macro and ahead). Moreover, the SI was also intended to stimulate the discussion around the emerging visions of CE model beyond the
mainstream and having the potential of promoting simultaneously at all
scales the values of environmental consciousness and adaptiveness, social justice, qualitative public well-being beyond purely quantitative
economic growth
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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