3,096 research outputs found
Facing the Future: the Changing Shape of Academic Skills Support at Bournemouth University
No full textThis paper explores the potential impact of changes to higher education in England on student expectations, engagement, lifestyles and diversity, and outlines implications for the development of digital literacy within academic skills support at Bournemouth University (BU). We will investigate how tackling resource constraints with organisational change can also enable efficient, centralised provision of support materials that utilise networks to overcome the risk of fragmented support for digital literacy. We will also look at how changing delivery modes for support can accommodate changing student lifestyles whilst tackling a weakness of centralised support for digital literacy: that it can become detached from the student’s subject-focused academic practice. Finally we will explore how involving students in developing support can help us to face changes to student expectations and engagement whilst ensuring that materials are authentic and speak to learners in their own voice
Maximizing Research Impact Through Institutional and National Open-Access Self-Archiving Mandates
No full textNo research institution can afford all the journals its researchers may need, so all articles are losing research impact (usage and citations). Articles made “Open Access,” (OA) by self-archiving them on the web are cited twice as much, but only 15% of articles are being spontaneously self-archived. The only institutions approaching 100% self-archiving are those that mandate it. Surveys show that 95% of authors will comply with a self-archiving mandate; the actual expe-rience of institutions with mandates has confirmed this. What institutions and funders need to mandate is that (1) immediately upon acceptance for publication, (2) the author’s final draft must be (3) deposited into the Institutional Repository. Only the depositing needs to be mandated; set-ting access privileges to the full-text as either OA or Restricted Access (RA) can be left up to the author. For articles published in the 93% of journals that have already endorsed self-archiving, access can be set as OA immediately; for the remaining 7%, authors can email the eprint in re-sponse to individual email requests automatically forwarded by the Repository
The Total Synthesis of Dragmacidins D and F
No full textThe dragmacidins are an emerging class of bis(indole) natural products isolated from deep-water marine organisms. Although there has been a substantial effort to prepare the simple piperazine dragmacidins, little synthetic work has been done in the area of the pyrazinone-containing family members, dragmacidins D, E, and F. These compounds are particularly interesting due to their complex structures and broad range of biological activity.
A highly convergent strategy to access dragmacidin D has been developed. In this approach, sequential halogen-selective Suzuki couplings were used to assemble the carbon scaffold of the natural product. After executing a highly optimized sequence of final events, the first completed total synthesis of dragmacidin D was achieved.
An enantiodivergent strategy for the total chemical synthesis of both (+)- and (-)-dragmacidin F from a single enantiomer of quinic acid has been developed and successfully implemented. Although unique, the synthetic routes to these antipodes share a number of key features, including novel reductive isomerization reactions, Pd(II)-mediated oxidative carbocyclization reactions, halogen-selective Suzuki couplings, and high-yielding late-stage Neber rearrangements.
The formal total syntheses of dragmacidin B, trans-dragmacidin C, and dihydrohamacanthin A are described. In addition, preliminary studies involving a novel approach for the preparation of dragmacidin E are reported.</p
Initial results of ultrasound screening for aneurysm of the abdominal aorta in Western Australia: relevance for endoluminal treatment of aneurysm disease
No full textMichael M. D. Lawrence-Brown, Paul E. Norman, Konrad Jamrozik, James B. Semmens, Neil J. Donnelly, Carole Spencer and Raywin Tuohyhttp://www.sciencedirect.com/science/journal/0967210
Jere Nash Interview with Neil McMillen (Part 1 of 2)
No full textInterview conducted by author Jere Nash with University of Southern Mississippi history professor Neil R. McMillen in the process of writing Mississippi Politics: The Struggle for Power, 1976-2006. Topics dicussed include race and politics in Mississippi; southern historians including Dewey Grantham, C. Vann Woodward, Numan V. Bartley, John Boles; segregation in Mississippi and resistance to change; genesis of McMillin\u27s book Dark Journey; fifteenth Freedom Summer reunion at Millsaps and Tougaloo; John Ditmer; contributing to A History of Mississippi edited by Richard Aubrey McLemore and reaction by the public and University of Southern Mississippi officials; hiring of African American faculty at USM; M.M. Roberts; and William D. McCain
Design innovation for the 1990's
No full textStatement of responsibility on title-page reads: Richard K. Lester, Michael J. Driscoll, Michael W. Golay, David D. Lanning, Lawrence M. Lidsky, Norman C. Rasmussen and Neil E. Todreas"September 1983."Includes bibliographical reference
‘THERE IS NOT AND NEVER HAS BEEN ANYTHING TO UNDERSTAND!’
No full text‘THERE IS NOT AND NEVER HAS BEEN ANYTHING TO UNDERSTAND!’, curated show with David Burrows including Plastique Fantastique works and artists: John Russell, Dean Kenning, Suzanne Treister, Simon Davenport, Reza Negarestani, Lawrence Leaman, Joanne Tatham & Tom O'Sullivan, John Gillis & Aline Bouvy, Benedict Drew, Peter Rockmount, Mark Jackson, John Cussans & Roberto Peyre, Pil & Galia Kollectiv, Neil Chapman & Ola Sahl, ASC Gallery, London (reviewed in ‘London Round-Up’, Art Monthly, September 2012, no. 359)
Dissimilarity is used as evidence of category membership in multidimensional perceptual categorization: a test of the similarity-dissimilarity generalized context model
No full textIn exemplar models of categorization, the similarity between an exemplar and category members constitutes evidence that the exemplar belongs to the category. We test the possibility that the dissimilarity to members of competing categories also contributes to this evidence. Data were collected from two 2-dimensional perceptual categorization experiments, one with lines varying in orientation and length and the other with coloured patches varying in saturation and brightness. Model fits of the similarity-dissimilarity generalized context model were used to compare a model where only similarity was used with a model where both similarity and dissimilarity were used. For the majority of participants the similarity-dissimilarity model provided both a significantly better fit and better generalization, suggesting that people do also use dissimilarity as evidence
Postcolonial Lawrence: the mexican connection
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente.Este trabalho lida com a produção de D.H.Lawrence enquanto o escritor inglês residia no México em 1923 e 1924, o romance The Plumed Serpent e os ensaios da coleção Mornings in Mexico, analisados de uma perspectiva pós-colonial. O projeto parte do pressuposto de que é tarefa do crítico pós-colonial, como Edward Said argumenta, tornar visível a ideologia contida nos textos imperiais e canônicos. Seria reducionista, no entanto, alegar que o material aqui analisado, em que pesem as estruturas coloniais que Lawrence necessariamente habita, seja "uniformemente imperialista". A complexidade do romance The Plumed Serpent reside precisamente no fato de que se pode observar uma ambivalência problemática: por um lado, um esforço inegável de Lawrence para tomar o partido das vítimas da Conquista Espanhola, o que leva o escritor a assumir uma postura "anti-imperialista", ainda que platônica, quando reverte papéis de figuras do episódio histórico, quais sejam, a figura de Hernán Cortés (criando um protagonista nativo mexicano que promove a reinstalação da religião Asteca, banindo o Cristianismo do México) e a figura de Malinche (amante e intérprete de Cortés); por outro lado, como qualquer sujeito imbricado em sua cultura, ele é inexoravelmente incapaz de atravessar o abismo que o separa do outro mexicano, e a questão da incomensurabilidade cultural se apresenta de forma infinitamente mais complexa do que ele poderia ter sonhado. O resultado de sua tentativa é que quanto mais ele verbaliza suas posições anti-eurocêntricas, mais o eurocentrismo se manifesta em seu discurso. Esse fenômeno é cuidadosamente analisado no capítulo sobre a questão racial (no qual investigo a relação entre Kate e Juana), também no capítulo intitulado "Utopian politics of resistance/orientalism", e ainda no capítulo que chamei "Barbaric Mexico". O capítulo III, "Pattern of role reversals: Fickle attempt of deconstruction" apresenta uma análise sistemática dos papéis históricos que Lawrence reverte em sua ficção. Por fim, o capítulo V apresenta uma análise rigorosa do contexto social do México enquanto Lawrence lá residiu e como ele se reflete no romance. A conclusão do trabalho aponta, à luz dos capítulos anteriores, para a dupla condição de Lawrence: por um lado, seu desejo de "desaprender a Europa" e sua vontade de resgatar "histórias esquecidas", seu genuino esforço, ainda que perturbado, de explorar diferença cultural; e, por outro lado, sua intensa dependência de construções históricas da própria cultura ocidental que ele tenta desafiar, e quão pouco consciente de suas limitações, enquanto sujeito de seu tempo e de sua cultura, ele foi. Como uma pessoa não-estabelecida e dividida, ele envereda pela tentativa de resistência a aspectos da ideologia imperialista, mas simultaneamente não consegue evitar as armadilhas da retórica do colonialismo
Biosynthesis of cobamides: Methods for the detection, analysis and production of cobamides and biosynthetic intermediates
No full textVitamin B12, cobalamin, belongs to the broader cobamide family whose members are characterized by the presence of a cobalt-containing corrinoid ring. The ability to detect, isolate and characterize cobamides and their biosynthetic intermediates is an important prerequisite when attempting to study the synthesis of this remarkable group of compounds that play diverse roles across the three kingdoms of life. The synthesis of cobamides is restricted to only certain prokaryotes and their structural complexity entails an equally complex synthesis orchestrated through a multi-step biochemical pathway. In this chapter, we have outlined methods that we have found extremely helpful in the characterization of the biochemical pathway, including a plate microbiological assay, a corrinoid affinity extraction method, LCMS characterization and a multigene cloning strategy
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