134,002 research outputs found
Reithrodontomys spectabilis Jones and Lawlor 1965
No full textReithrodontomys spectabilis Jones and Lawlor, 1965. Univ. Kansas Pubi., Mus. Nat. Hist., 16:413. TYPE LOCALITY: Mexico, Quintana Roo, Isla Cozumel, 2.5 km N San Miguel. DISTRIBUTION: Restricted to Cozumel Island, Mexico. COMMENTS: Subgenus Aporodon, mexicanus species group. A large insular species, perhaps sharing common ancestry with R. gracilis (Jones and Lawlor, 1965). See Jones (1982, Mammalian Species, 193).Published as part of Guy G. Musser & Michael D. Carleton, 1993, Order Rodentia - Family Muridae, pp. 501-755 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 742, DOI: 10.5281/zenodo.735309
Nonlinear Exposure-Outcome Associations and Public Health Policy
No full textAbigail Fraser, Debbie A. Lawlor, Laura D. How
A life course approach to cardiovascular aging.
No full textA life course approach in epidemiology investigates the biological, behavioral and social pathways that link physical and social exposures and experiences during gestation, childhood, adolescence and adult life, and across generations, to later-life health and disease risk. We illustrate how a life course approach has been applied to cardiovascular disease, highlighting the evidence in support of the early origins of disease risk. We summarize how trajectories of cardiometabolic risk factors change over the life course and suggest that understanding underlying 'normal' or 'healthy' trajectories and the characteristics that drive deviations from such trajectories offer the potential for early prevention and for identifying means of preventing future disease
Discussant chapter: using family-based designs in life course epidemiology
No full textThe three chapters in this section offer different but complementary conceptualizations of ‘family’. Morton and Rich Edwards used ‘family’ to document intergenerational concordance of reproductive outcomes, Hatch and Mishra documented how ‘family’ could be characterized as a risk exposure for later poor mental health, and Lawlor and Leon used ‘family’ as a means to control for unmeasured confounding by family characteristics to better understand causal mechanisms relating fetal growth to later disease. Lawlor and Leon’s approach is similar to that used in studies examining the possible intrauterine origins of birth weight and cognitive ability and we briefly explore that literature. Families surely matter for better understanding individual and population patterns of ill-health. If we know how families transmit different diseases across generations then it may elucidate novel or under-exploited avenues for prevention.John Lynch and Seungmi Yan
Homogeneous assay of rs4343, an ACE I/D proxy, and an analysis in the British Women's Heart and Health Study (BWHHS).
No full textCurrent literature suggests that ACE SNP rs4343, ACE 2350A>G in exon 17, T202T, may be the best proxy for the ACE Alu I/D whereas rs4363 and rs4362 may be slightly stronger predictors of ACE levels. Considering reported difficulties in genotyping ACE I/D and stronger associations of rs4343 than ACE I/D with plasma ACE levels in Africans, and suitability of rs4343 for allelic mRNA (cDNA) studies, we developed and validated a liquid phase assay for rs4343, which has advantage on both functional and technical grounds. We confirmed that rs4343, is in near perfect linkage disequilibrium (D'=1, r2=0.88, n=64) with ACE I/D in Europeans (A and G alleles of rs4343 marking insertion and deletion alleles of ACE I/D respectively). We then studied its association with metabolic and cardiovascular traits in 3253 British women (60-79 years old). Apart from a nominal trend of association with diastolic blood pressure (p anova=0.08; p trend=0.05), no other associations were observed. A post-hoc vascular and general phenome scan revealed no further associations. We conclude that ACE I/D is not a major determinant of metabolic and cardiovascular traits in this population. Liquid phase genotyping of SNP rs4343 may be preferable to gel based ACE I/D genotyping both for technical and functional reasons
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
State of the art of biofuels from pure plant oil
No full textThe pollution caused by fuel combustion either for mechanical or electrical energy generation purposes is nowadays one of the most important environmental issues. It has been proven that combustion emissions, particularly those from cars and trucks, are linked with severe damages to the environment and human health. Along with the environmental problems, is necessary to consider that fossil resources are declining and their exploitation is getting more and more expensive. Bioenergy represent a sustainable solution for energy generation. Bioenergy is renewable energy made from plant-derived organic matter, collectively termed "biomass". Biomass-based energy sources are potentially carbon dioxide neutral and recycle the same carbon atoms. Life cycle assessments are reported to evaluate the net environmental impacts of biofuels. The term biofuel refers to liquid or gaseous fuels for the internal combustion engines that are predominantly produced from biomass. Biofuel policy might capitalize on the production of biofuels supporting rural economic development and sustainable agriculture. Amongst biofuels pure plant oil (PPO) has been investigated. This paper sets out to review the state of the art for PPO use as fuel in diesel engines, based on a wide literature review
- …
