1,720,993 research outputs found
Pharmacokinetics of methylphenidate following two oral formulations (immediate and sustained release) in the dog
No full textMitochondrial cytochrome c oxidase subunit 1 (cox1) gene sequence of Spirocerca lupi (Nematoda, Spirurida) from different geographical areas: avenues for potential implications
No full textCanine spirocercosis is a life-threatening parasitosis caused by Spirocerca lupi (Nematoda, Spirurida) that is presently emergingin several countries. This study characterised an informative region within the mitochondrial (mtDNA) gene encoding for thecytochrome c oxidase subunit 1 (cox1) of S. lupi by Polymerase Chain Reaction (PCR)-coupled sequencing. Specimens from fivedifferent countries in Europe, Asia and Africa were examined and two different sequence variants of cox1 (i.e. haplotypes) weredetermined, displaying nucleotidic variation at 6 of 689 positions. All of these positions were invariable among all the parasiteindividuals from Europe (haplotype 1) and among the African and Asian individuals (haplotype 2), but differed between Europe andAsia/Africa. The S. lupi cox1 sequences were consistent with those of other common Spirurida previously reported at bothnucleotidic and phylogenetic levels. This study provides molecular information essential for identification of the nematode,irrespective of its life cycle stage. Crucial implications for the specific molecular diagnosis of clinical spirocercosis andinvestigation of the evolution, population genetics, ecology and epidemiology of S. lupi are discussed.[...
PRELIMINARY PHARMACOKINETIC EVALUATIONS OF PARECOXIB FOLLOWING INTRAVENOUS ADMINISTRATION IN HEALTHY BEAGLE DOGS
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
USE OF THE NOVEL ATYPICAL OPIOID TAPENTADOL IN GOATS (CAPRA HIRCUS): PHARMACOKINETICS AFTER INTRAVENOUS, AND INTRAMUSCULAR ADMINISTRATION
No full textThe objective of the present study was to assess the pharmacokinetics of the
novel atypical drug tapentadol (TAP) after intravenous (I.V.) and intramuscular
(I.M.) injections in clinically healthy goats. A 2 9 2 cross-over design
study was carried out. Six local adult Nubian nonlactating, nonpregnant
female goats, were given 5 mg/kg body weight of TAP by I.V. and I.M.
routes. The concentrations of TAP in plasma were evaluated using a validated
HPLC method. Transient adverse effects were noticed in some animals,
especially after I.V. administration (tremors and ataxia). Three days after
drug administration, severe hair loss was also recorded. The plasma
concentrations after the two routes of administration were best described by
a bi-compartmental model. After I.M. injection, TAP showed a very fast
absorption (Tmax = 0.17 h) and a short half-life (1.29 h). The I.M. bioavailability
was quite high, despite being variable (87.8 35.6%). This is the first
pharmacokinetic study of TAP in goats but due to its unknown safety profile
and efficacy, it is premature to recommend the use of this drug in clinical
ovine practice
- …
