1,721,220 research outputs found
Synovial chondromatosis and chondrosarcoma of the hip: Indications for surgical treatment
No full textFive cases of cartilaginous neoproliferation of the hip, of synovial origin, were treated by different surgical techniques. From the clinical point of view these cases can be classified as simple synovial chondromatosis and progressive synovial chondromatosis. The writers, on the basis of their own experience and on data collected from the literature, conclude that simple synovial chondromatosis should be treated by partial or total synovectomy, while progressive synovial chondromatosis should be treated by total synovectomy with or without arthroplasty with total hip prosthesis. Synovial chondrosarcoma should be considered a neoplasm with at least local malignancy and should be treated by wide surgery
First evidence of a protective effect of plant bioactive compounds against h2o2-induced aconitase damage in durum wheat mitochondria
No full textIn order to contribute to the understanding of the antioxidant behavior of plant bioactive compounds with respect to specific subcellular targets, in this study, their capability to protect aconitase activity from oxidative-mediated dysfunction was evaluated for the first time in plant mitochondria. Interest was focused on the Krebs cycle enzyme catalyzing the citrate/isocitrate interconversion via cis-aconitate, as it possesses a [4Fe-4S]2+ cluster at the active site, making it an early and highly sensitive target of reactive oxygen species (ROS)-induced oxidative damage. In particular, the effect on the aconitase reaction of five natural phenols, including ferulic acid, apigenin, quercetin, resveratrol, and curcumin, as well as of the isothiocyanate sulforaphane, was investigated in highly purified mitochondria obtained from durum wheat (DWM). Interestingly, a short-term (10 min) DWM pre-treatment with all investigated compounds, applied at 150 μM (75 μM in the case of resveratrol), completely prevented aconitase damage induced by a 15 min exposure of mitochondria to 500 μM H2O2. Curcumin and quercetin were also found to completely recover DWM-aconitase activity when phytochemical treatment was performed after H2O2 damage. In addition, all tested phytochemicals (except ferulic) induced a significant increase of aconitase activity in undamaged mitochondria. On the contrary, a relevant protective and recovery effect of only quercetin treatment was observed in terms of the aconitase activity of a commercial purified mammalian isoform, which was used for comparison. Overall, the results obtained in this study may suggest a possible role of phytochemicals in preserving plant mitochondrial aconitase activity, as well as energy metabolism, against oxidative damage that may occur under environmental stress conditions. Further investigations are needed to elucidate the physiological role and the mechanism responsible for this short-term protective effect
THE NEW LOX/RNO METHOD ALLOWS MEASUREMENT OF HIGH ANTIOXIDANT ACTIVITY OF FREE AND BOUND PHENOLS IN SEEDS OF CEREAL SPECIES
No full textTHE REACTION BETWEEN SOYBEAN LIPOXYGENASE–1 ISOENZYME AND FLUORESCEINE AS A NOVEL TOOL TO ASSESS ANTIOXIDANT ACTIVITY IN FOODS
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate.
No full textOBJECTIVE: This study evaluates the effects of long-term carbamazepine (CBZ) and valproate acid (VPA) therapy on thyroid function in epileptic children. DESIGN: A prospective study performed in 32 newly diagnosed pediatric patients, subdivided into two groups: 18 patients treated with CBZ and 14 patients treated with VPA. Thirty-two sex- and age- matched subjects served as controls. METHODS: Serum TSH, thyroxine (T(4)), triiodothyronine (T(3)), free thyroxine (fT(4)), free triiodothyronine (fT(3)), thyroid peroxidase antibodies (TPO-Ab), and thyroglobulin antibodies (TG-Ab) were evaluated at baseline and at the 3rd, 6th, and 12th month in all patients and in the control group. A TRH stimulation test was performed in all epileptic patients at baseline and at the 3rd, 6th, and 12th month evaluations while in controls only baseline assessment was carried out. RESULTS: At baseline evaluation, thyroid function was normal in all epileptic children. After 3 months, CBZ-treated patients showed serum T(4) and fT(4) levels significantly lower than baseline evaluation and control subjects. Serum T(4) and fT(4) concentrations were unaffected by VPA monotherapy. Serum T(3) and fT(3) were normal in both CBZ-treated and VPA-treated patients. TRH test was normal in all patients. At 6th and 12th month evaluations, the same alterations were present in CBZ-treated patients while thyroid function remained normal in VPA-treated patients. TRH test responses were normal in all epileptic patients. TPO-Ab and TG-Ab were always absent in all patients. CONCLUSIONS: Our data suggest that VPA monotherapy does not alter thyroid hormones. On the contrary, alterations of thyroid hormones occur in CBZ-treated children. However, the patients are euthyroid and thyroid hormone alterations are not associated with clinical or subclinical hypothyroidism
Possible role of a mitochondrial phospholipase A2 activity in durum wheat (Triticum Durum Desf.) response to hyperosmotic stress mediated by activation of the dissipative systems
No full textMetabolite transport pathways in durum wheat mitochondria from hyperosmotically-stressed seedlings.
No full textNew macromolecular ligands. Basicity and complexing properties of monomeric and polymeric dicarboxylic aminoacids
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