1,721,399 research outputs found
Insulin glargine in enteric tube feeding.
No full textDiabetes Res Clin Pract. 2007 Nov;78(2):298-9. Epub 2007 May 3.
Insulin glargine in enteric tube feeding.
Marchetti G, Tesauro M, Di Daniele N, Bollea MR, Lauro R, Bertoli A.
Insulin glargine, a long-acting insulin analogue, was
introduced to provide effective basal insulin replacement
with once-daily dosing. An insulin regimen with
insulin glargine allows optimal glucose control with a
lower risk of hypoglycaemia compared with neutral
protaminated hagedorn insulin in Type 2 diabetes [1,2].
Recently, insulin glargine has been proposed for
patients on continuous enteral artificial nutrition [3,4].
We report an 18-month follow-up of a patient treated
with basal insulin glargine during continuous enteral
nutrition and thereafter during intermittent enteral
nutrition without evidence of hypoglycaemic events
An extracellular domain of the insulin receptor ß-subunit with regulatory function on protein-tyrosine kinase
No full textAnti-insulin receptor monoclonal antibody MA-10 inhibits insulin receptor autophosphorylation of purified rat liver insulin receptors without affecting insulin binding (Cordera, R., Andraghetti, G., Gherzi, R., Adezati, L., Montemurro, A., Lauro, R., Goldfine, I. D., and De Pirro, R. (1987) Endocrinology 121, 2007-2010). The effect of MA-10 on insulin receptor autophosphorylation and on two insulin actions (thymidine incorporation into DNA and receptor down-regulation) was investigated in rat hepatoma Fao cells. MA-10 inhibits insulin-stimulated receptor autophosphorylation, thymidine incorporation into DNA, and insulin-induced receptor down-regulation without affecting insulin receptor binding. We show that MA-10 binds to a site of rat insulin receptors different from the insulin binding site in intact Fao cells. Insulin does not inhibit MA-10 binding, and MA-10 does not inhibit insulin binding to rat Fao cells. Moreover, MA-10 binding to down-regulated cells is reduced to the same extent as insulin binding. In rat insulin receptors the MA-10 binding site has been tentatively localized in the extracellular part of the insulin receptor beta-subunit based on the following evidence: (i) MA-10 binds to insulin receptor in intact rat cells; (ii) MA-10 immunoprecipitates isolated insulin receptor beta-subunits labeled with both [35S]methionine and 32P; (iii) MA-10 reacts with rat insulin receptor beta-subunits by the method of immunoblotting, similar to an antipeptide antibody directed against the carboxyl terminus of the insulin receptor beta-subunit. Moreover, MA-10 inhibits autophosphorylation and protein-tyrosine kinase activity of reduced and purified insulin receptor beta-subunits. The finding that MA-10 inhibits insulin-stimulated receptor autophosphorylation and reduces insulin-stimulated thymidine incorporation into DNA and receptor down-regulation suggests that the extracellular part of the insulin receptor beta-subunit plays a role in the regulation of insulin receptor protein-tyrosine kinase activity
Several regions of Antennapedia and thyroid transcription factor 1 homeodomains contribute to the DNA binding specificity
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Calreticulin enhances the transcriptional activity of thyroid transcription factor-1 by binding to its homeodomain.
No full textPartial purification of a thyroid specific nuclear protein recognizing the thyroglobulin promoter
No full textWe have used a gel retardation assay to follow the purification of a calf thyroid nuclear protein that binds to the -70 region of the rat thyroglobulin promoter. The activity producing the observed band shift is thyroid specific. The same shift is in fact observed with extracts prepared from a differentiated rat thyroid cell line which synthesizes and secretes thyroglobulin, while no similar shift is detected when cell unable to express their endogenous thyroglobulin gene or tissues different from thyroid are used as a source of nuclear extract. Competition experiments suggest that the same protein may bind at two different sites within the promoter. The two sites display considerable sequence homology. Sequence comparisons between the rat, calf and human promoter suggest that more than the sequence is the geometry of the promoter which is conserved
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