1,721,235 research outputs found
Perspectives in medicinal chemistry
No full text“Perspective in Medicinal Chemistry” aims to cover all the latest outstanding developments of medicinal
chemistry applied to dentistry. This new journal will describe recent research and developments in the field of medicinal chemistry and dentistr
Decayed, missing and filled teeth index and dental anomalies in long-term survivors leukaemic children: A prospective controlled study.
Full text linkObjective: The aim of this prospective controlled study is the comparison between long-term children survived leukaemia and a control group in terms of the decayed, missing or filled permanent teeth (DMFT) and dental anomalies. Study design: Fifty-two long term children survived leukaemia, aged from 8 to 15 years (27 females, 25 males; mean age 11.5 years) were evaluated for the possible effects of the anti-leukaemic therapy on dental development and compared to a control group of 52 healthy children (27 females, 25 males, mean age 11 years). All long-term children who survived were at least 24 months in continuous complete remission. The study of the dental status with a routine oral examination and panoramic radiographs was performed. The DMFT (recorded according to the WHO criteria) and dental anomalies were registered and evaluated. Results: The results of this study evidence that long-term children survived leukaemia, in comparison with the control group, have an higher risk to develop dental caries and show a greater severity of dental anomalies including V-shaped roots, dental agenesis, microdontia, enamel dysplasias. Conclusions: Paediatric patients with haemathological diseases require a special attentions in dental care in addition to the antineoplastic treatment. Therefore, oral hygiene and oral health can be maintained thanks to a close cooperation between the paediatric oncohaematologists, pediatrics dental surgeons and dental hygienists
Management odontostomatologico del paziente pediatrico emato-oncologico [Odontostomatologic management of hematooncologic pediatric patients]
No full textAim: dentists both as clinical practice and research increased progressively their interest in leukemia, because the oral complications are common during the outcome of the disease, dental management is complex, and the mouth is a potential source of morbidity. Dental Clinic of University of Milan-Bicocca has prepared, in collaboration with the Hematologic Pediatric Department, guidelines for dental treatment of children affected by leukemia. Dentists, who take care of leukemic children, have several roles: diagnostic, preventive, therapeutic and supportive role. Diagnostic role: head and neck signs resulting from leukemic infiltrates include cervical lymphadenopathy, oral bleeding, gingival infiltrates, oral infections, and oral ulcers. Thrombocytopenia and anemia manifest in pallor of the mucosa, petechiae, and ecchymoses, as well as gingival bleeding. Spontaneous gingival bleeding is common when the platelet count falls below 20.000/mm3. Preventive role: dental treatment to eliminate potential sources of oral infection, such as teeth with caries, pulpitis, moderate to severe periodontal disease, is accompanied by a significant reduction in the rate of septicemia. The early diagnosis of oral infection is mandatory because oral disease is considered a true source of potentially life-threatening infection from gram-positive and gram-negative bacilli. The oral flora is the most likely sources of septicemia in 50% of cases. Therapeutic role: it is dentists' duty to develop screening evaluation and remove sources of infection before chemotherapy has started, following subsequent guidelines: complete oral examination, removal of orthodontic brackets, conservative therapy, professional hygiene, resolution of inflammation, extraction of compromised teeth, even if platelet transfusion and intravenous combinated antibiotics may be required before. The use of absorbable gelatin or collagen sponges, topical thrombin, or the placement of microfibrillar collagen held in place by packing or splints are helpful. Supportive role: as survival rate of children with cancer increased significantly during the past decades, late effects of antineoplastic therapy become important to be forwarded. Children with acute lymphoblastic leukemia received brain radiation and chemotherapy to prevent a relapse. Craniofacial deformities and dental anomalies are quite common in children who receive this therapy, expecially before age 5. The most common abnormalities reported in children were deficient mandibular development, dental agenesis, arrested root development, microdontia, and enamel dysplasia. Conclusions: Leukemic children need special care. Appropriate oral hygiene and health should be manteined and restored before development of irreversible dental damage: only a close cooperation among pediatric hematoncologists, pediatric dental surgeons, and dental hygienists could guarantee these. In the last 5 years we have treated 317 leukemic children and have made 5292 dental care. Our experience suggests that even if detrimental impact of antineoplastic therapy on oral cavity is unavoidable, it could be diminished with an adequate and correct preventive or curative therapy contributing to a better quality of life of children treated for leukemia.Aim: dentists both as clinical practice and research increased progressively their interest in leukemia, because the oral complications are common during the outcome of the disease, dental management is complex, and the mouth is a potential source of morbidity. Dental Clinic of University of Milan-Bicocca has prepared, in collaboration with the Hematologic Pediatric Department, guidelines for dental treatment of children affected by leukemia. Dentists, who take care of leukemic children, have several roles: diagnostic, preventive, therapeutic and supportive role. Diagnostic role: head and neck signs resulting from leukemic infiltrates include cervical lymphadenopathy, oral bleeding, gingival infiltrates, oral infections, and oral ulcers. Thrombocytopenia and anemia manifest in pallor of the mucosa, petechiae, and ecchymoses, as well as gingival bleeding. Spontaneous gingival bleeding is common when the platelet count falls below 20.000/mm3. Preventive role: dental treatment to eliminate potential sources of oral infection, such as teeth with caries, pulpitis, moderate to severe periodontal disease, is accompanied by a significant reduction in the rate of septicemia. The early diagnosis of oral infection is mandatory because oral disease is considered a true source of potentially life-threatening infection from gram-positive and gram-negative bacilli. The oral flora is the most likely sources of septicemia in 50% of cases. Therapeutic role: it is dentists' duty to develop screening evaluation and remove sources of infection before chemotherapy has started, following subsequent guidelines: complete oral examination, removal of orthodontic brackets, conservative therapy, professional hygiene, resolution of inflammation, extraction of compromised teeth, even if platelet transfusion and intravenous combinated antibiotics may be required before. The use of absorbable gelatin or collagen sponges, topical thrombin, or the placement of microfibrillar collagen held in place by packing or splints are helpful. Supportive role: as survival rate of children with cancer increased significantly during the past decades, late effects of antineoplastic therapy become important to be forwarded. Children with acute lymphoblastic leukemia received brain radiation and chemotherapy to prevent a relapse. Craniofacial deformities and dental anomalies are quite common in children who receive this therapy, expecially before age 5. The most common abnormalities reported in children were deficient mandibular development, dental agenesis, arrested root development, microdontia, and enamel dysplasia. Conclusions: Leukemic children need special care. Appropriate oral hygiene and health should be manteined and restored before development of irreversible dental damage: only a close cooperation among pediatric hematoncologists, pediatric dental surgeons, and dental hygienists could guarantee these. In the last 5 years we have treated 317 leukemic children and have made 5292 dental care. Our experience suggests that even if detrimental impact of antineoplastic therapy on oral cavity is unavoidable, it could be diminished with an adequate and correct preventive or curative therapy contributing to a better quality of life of children treated for leukemia
Immediate loading in mandible full-arch: pilot study in patients with osteoporosis in bisphosphonate therapy.
No full textDental implants have been used clinically in a routine manner to restore completely edentulous mandibles. A recent systematic review of the literature conducted by Bryant1 describes the 5-year cumulative survival rates of mandibular fixed and removable prostheses between 83% and 100%, with corresponding levels of crestal bone loss up to 1.1 mm the first year and 0.4 mm per year thereafter. The author included in his review studies using the classical two-stage surgical approach, whereby the implant is initially covered underneath the mucosa and kept unloaded for 4–6 months.2 However, over the past decade changes in dental implant design and surface configuration combined with an improved understanding of the biological and biomechanical aspects have improved the clinical outcome of implant treatments.3 These advancements have led to the one-stage surgical procedures in conjunction with earlier loading, especially in the completely edentulous mandible
Preliminary protocol for systemic administration of capsaicin for the treatment of the burning mouth syndrome
No full textThe efficacy of hybenx® oral tissue decontaminant for periodontal disease treatment: a case series study
No full textThe objective of this study was to evaluate the efficacy of a chemical device HYBENX® Oral Tissue Decontaminant in the treatment of chronic periodontitis in adult patients. With the aim to identify the antibacterial property of HYBENX®, two samples of periodontal pocket microbiota were collected by paper probes, at two different time points. T0 represents the first sampling performed before treatment while T1 represents the second time point, 15 days after HYBENX® treatment. A total of 11 patients were enrolled. For each patient, at each time point, two paper probes were collected. Polymerase Chain Reaction methodology was used to detect microbial activity. After the treatment, a remarkable decrease in bacteria amount was observed, both for total bacteria and some specific periodontal pathogens representing the red complex bacteria (i.e. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia). The average reduction was about 99% for each of the red complex bacteria and about 96% for total Bacteria. This decrease was highly statistically significant based on P-values. HYBENX® solution is an effective adjunct to eradicate bacterial loading in the pockets of patients affected by periodontitis. It is an efficacious medical device for use in the management of moderate to severe chronic periodontiti
Affrontare l'AIDS. Programmi di prevenzione e strategie terapeutiche [Confronting AIDS. Prevention programs and therapeutic strategies]
No full textHIV pathology and AIDS patterns represent a topical and serious reality. Now AIDS syndrome affects many types of population all ever the world. These types have different epidemiologic ratings according to the localization of the countries (3rd world or developed areas). Global Programme on AIDS (GPA) had a rapid development from its beginning (February 1987) with the aid of more than 150 national programs; in fact a lot of countries have developed and applied their own AIDS projects. OMS helped these programs giving indications and informative material about: promotion of health, check-up of HIV infections, prevention, epidemiologic control, services for laboratory and transfusion centres, treatment in general and counselling activities. Therefore it is very important to integrate medical activities and every intervention on AIDS in every sanitary and social service. To fight this dramatic reality, we must operate on two fronts: the first is the prevention and the second is the correct diagnostic and therapeutic approach. These are the purposes of medicine in general and odontostomatology in particular
Relazione tra nevi e melanomi : Rassegna della letteratura [Relationship between nevus and melanoma. Review of the literature]
No full textThe main purpose of this paper is to explain the development of the thought and the most updated considerations about the correlations between nevi and melanoma, through a critical review in chronological order of the scientific publications about it since 1969. This leads to the discussion, correction and recovery of thoughts that had been left. In fact we know that a kind of correlation exists but, until now, has not been completely explained
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