1,721,054 research outputs found
Basal cell adenoma with S-100 positive stroma: a case report and literature review
No full textBasal cell adenoma (BCA) of the salivary gland with presence of abundant S-100-positive stromal cells has been rarely reported. A case occurring in a 75-year-old man is presented here, as well as a review of the literature on the subject. The patient presented with a nodule in the right parotid gland. In addition to the typical features of BCA, histologically the resected tumor showed a substantial amount of stroma rich in S-100-positive spindle cells, a rarely reported finding in BCA. These cells were unreactive with a panel of myoepithelial markers, including calponin, p63, muscle-specific actin (MSA), smooth muscle actin (SMA), cytokeratin 14 (CK14), and glial fibrillary acidic protein (GFAP). Our results, in accordance with other reports, do not support a myoepithelial nature of these S-100-positive cells, and their precise nature remains elusive
Isolated intramedullary cervical spinal cord metastasis from colon cancer: a surgical or medical challenge?
No full textN/
Ectopic immature renal tissue: clues for diagnosis and management
No full textEctopic immature renal tissue has rarely been reported in literature, associated or not with teratoma. Its finding could be matter of concern, owing to the occasional possibility that Wilms tumor may develop in this setting. We report a 1-year-old male patient who underwent surgery for a sacral subcutaneous small teratoma with a prevalent component of immature renal tissue. The lesion appeared completely excised and, in absence of features of malignancy, only follow-up was suggested. The patient was alive and well 15 months postoperatively. Whenever ectopic immature renal tissue is detected, a proper histological interpretation is mandatory, in order to plan a suitable treatment of the patient. From an extensive analysis of cases reported in literature we draw some practical suggestions for the diagnosis and treatment of this rare condition
Spontaneous regression of pineal lesions: ghost tumor or pineal apoplexy?
No full textPineal apoplexy (either hemorrhagic or ischemic) may complicate the course of a tumor at this site. This event is usually characterized by an acute clinical onset and requires emergency surgical management while the regression of the lesion is a much rarer outcome.
MATERIAL AND METHODS:
Three cases of pineal vanishing tumors in the pediatric population are reported and the pertinent literature is reviewed.
RESULTS:
In one case radiological findings were consistent with a diagnosis of pineal cyst, which became symptomatic after a spontaneous hemorrhage. This event may also explain its regression after the treatment of associated hydrocephalus. In the remaining two cases, neuroimaging examinations disclosed a solid tumor. One of them regressed after a surgical biopsy, probably because of an ischemic evolution, while the last one disappeared without any medical or surgical manipulation. Neither hemorrhage nor ischemia were noticed, thus the mechanism of regression remains controversial.
CONCLUSIONS:
Vanishing tumors of the pineal region may occur in different circumstances, resulting from absence of any medical and surgical action to minor manipulation of the tumor to obtain a biopsy. This variety may reflect different underlying mechanisms, leading to hemorrhagic or ischemic change of the tumor and its subsequent regression, although radiological imaging may fail to document hemorrhage or ischemia
Basal cell adenoma with S-100 positive stroma: a case report and literature review
No full textBasal cell adenoma (BCA) of the salivary gland with presence of abundant S-100-positive stromal cells has been rarely reported. A case occurring in a 75-year-old man is presented here, as well as a review of the literature on the subject. The patient presented with a nodule in the right parotid gland. In addition to the typical features of BCA, histologically the resected tumor showed a substantial amount of stroma rich in S-100-positive spindle cells, a rarely reported finding in BCA. These cells were unreactive with a panel of myoepithelial markers, including calponin, p63, muscle-specific actin (MSA), smooth muscle actin (SMA), cytokeratin 14 (CK14), and glial fibrillary acidic protein (GFAP). Our results, in accordance with other reports, do not support a myoepithelial nature of these S-100-positive cells, and their precise nature remains elusive
GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system
No full textAim: Primary melanocytic tumours are uncommon neoplasms of the central nervous system. Although similarities with uveal melanomas have been hypothesized, data on their molecular features are limited. Methods: In this study, we investigated the mutational status of BRAF (V600E) , KIT, GNAQ, GNA11, N-RAS and H-RAS in a series of 19 primary melanocytic tumours of the CNS. Results: We identified six cases harbouring mutations in the hotspot codon 209 of the GNAQ gene and two cases with mutations in the hotspot codon 209 of the GNA11 gene. Two mutations in codon 61 of N-RAS were also found. In the SSCP analysis, no shifts corresponding to BRAF(V600E) mutations or suggesting activating mutations in the KIT gene were observed. Conclusions: In primary melanocytic tumours of the CNS, GNA11 and N-RAS mutations represent a mechanism of MAPK pathway activation alternative to the common GNAQ mutations. On the other hand, BRAF(V600E) mutations and activating KIT mutations seem to be absent or very rare in these tumours. © 2012 The Authors. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society
Usefulness of 18F-FDG PET/CT in Disease Extent and Treatment Response Assessment in a Patient With Syphilitic Aortitis
No full textA 40-year-old man was admitted to our hospital for surgical treatment
of aortic insufficiency and coronary ostial stenosis. Histopathology and
serological tests revealed a syphilitic aortitis. 18F-FDG PET/CTwas performed
to assess the extent of aortitis, showing increased radiopharmaceutical uptake
along the ascending aortic wall. A repeated FDG PET/CTafter antibiotic therapy
showed a markedly reduced uptake in the aortic wall, suggesting resolution of
the infection according to clinical and serological data. This case highlights the
usefulness of FDG PET/CT for the assessment of disease extent and treatment
response in patients with syphilitic aortitis
Intracranial neuromuscular choristoma: Report of a case with literature review
No full textNeuromuscular choristoma (NMC), also called neuromuscular hamartoma or nerve rhabdomyoma, is a rare lesion of the spinal and cranial nerves composed of skeletal muscle intimately associated with nerve fibers. Its origin has not been precisely clarified and a malformative event, resulting from aberrant differentiation or a true neoplastic growth, have been proposed by authors. We hereby present a cerebellopontine angle NMC enlarging the eighth cranial nerve in a 3-year-old child, that histologically appeared composed of a large amount of striated muscle mixed with nerve fibers. We also provide a review of the intracranial NMC cases reported in the literature and an analysis of proposed hypotheses to explain the presence of muscle cells in nerve trunks
Congenital epulis: an ultrastructural and immunohistochemical study
No full textIn the light of recent findings concerning the presence of S-100 antigen in granular cell myoblastoma (GCM), we investigated by immunoperoxidase the presence of this antigen in a case of congenital epulis (CE). The absence of S-100 in CE granular cells is suggestive for antigenic differences with GCM. Upon ultrastructural investigation, bundles of collagen fibers were observed in the cytoplasm of CE granular cells and cells displaying features of initial cytoplasmic vacuolar transformation were also detected. Interstitial cells containing angulated bodies, a common finding in GCM, were not found
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