271 research outputs found
Steve Stockton & Father Martin Magill
No full textRev. Steve Stockton and Fr. Martin Magill share their story speak on the importance of peacemaking and reconciliation in the places you live.
Rev Steve Stockton is minister of Fitzroy Presbyterian Church in Belfast (winners of the Pax Christi Peace Prize) and is author of Walk On; The Spiritual Journey of U2 and is a daily blogger at Soul Surmise where he writes about Art, faith and social justice. Fr Martin Magill is the priest of Sacred Heart Parish in Belfast and studied his Masters Degree in Ecumenism in Rome. The two of them met for a coffee and it changed their lives. A friendship developed that has over more coffee led to the founding of the acclaimed 4 Corners Festival and to the two of them being invited to the Sinn Fein party conference to address that party on Peace and Reconciliation. They have become very much a double act in modeling and working for peace in Ireland. They have also been involved in various peace talks with other international situations
Memorandum to Colonel W. L. Magill, Jr. Provost Marshal and Director of Evacuation
No full textMemorandum to the Colonel W.L. Magill Jr., Provost Marshal and Director of Evacuation presumably from a committee with the following members: Galen M. Fisher, Gordon Chapman, C. A. Richardson, and F. H. Smith. The memo includes the following subtitles: General Purpose and General Considerations.The Bishop James Chamberlain Baker Collection includes letters, documents, and articles about Japanese Americans during World War II. Subjects in the collection include Japanese Americans mass removal, Pearl Harbor and the aftermath, religion, and support from the non-Japanese American community. The collection was digitized and made accessible online by CSUDH Gerth Archives and Special Collections
Memo sent to Mr. Neustadt from Colonel W. F. Magill, Jr., Provost Marshal Western Defense Command and Fourth Army, April 4, 1942
No full textA memo sent to Mr. Neustadt from Colonel W. F. Magill, Jr. regarding travel during non-curfew hours. Proclamation No. 3 restricted what travel was permissible by German, Italian, and Japanese aliens in Military Area No. 1. The memo was posted by Karl R. Bendetsen, Assistant Chief of Staff, Civil Affairs Division, for the reference of all C. A. D. and Wartime Civil Control Administration staff.The War Relocation Authority (WRA), together with the Wartime Civil Control Administration (WCCA), the Civil Affairs Division (CAD) and the Office of the Commanding General (OFG) of the Western Defense Command (WDC) operated together to segregate and house some 110,000 men women and children from 1942 to 1945. The collection contains documents and photographs relating to the establishment and administrative workings of the (WDC), the (WRA) and the (WCCA) for the year 1942
Sonata in F Major, Op. 99 (1886)
No full textAllegro vivace -- Adagio affettuoso -- Allegro passionato -- Allegro molt
Sonata in E Major
No full textAdagio cantabile -- Allegro vivo -- Tempo di gavotta -- Largo cantabile -- Gigue: Allegro vivac
Porter v Magill [2001] UKHL 67, House of Lords
No full textEssential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Porter v Magill [2001] UKHL 67, House of Lords. The document also includes supporting commentary from author Thomas Webb.</p
Immune-phenotyping of B cells unsing LEGENDScreen(TM) to investigate the role of B cells in immunogenicity, and immune regulation by Bregs, in patients with Rheumatoid Arthritis
No full textRheumatoid arthritis (RA) is a multifactorial disease associated with failure of immune tolerance. B cells play a prominent role in the pathogenesis of this disease, via the production of auto-antibodies, pro-inflammatory cytokines, and an impaired regulatory B cell (Breg) response. Biologic drugs have significantly advanced the treatment of RA but are not always effective and indeed the development of anti-drug antibodies (ADA) has been associated with a poorer clinical outcome. Here I set out, firstly, to identify a predictive biomarker that discriminates RA patients who are more likely to develop ADA in response to adalimumab, a human monoclonal antibody against tumor necrosis factor (TNF)α. By taking advantage of an immune-phenotyping platform, LEGENDScreenTM, I measured the expression of 332 cell surface markers on B and T cells in a cross-sectional adalimumab-treated RA patient cohort with a defined ADA response. The analysis revealed seven differentially expressed markers between the ADA+ and ADA- patients. Validation of the differentially expressed markers in an independent prospective European cohort of adalimumab treated RA patients, revealed a significant and consistent reduced frequency of signal regulatory protein (SIRP)α/β-expressing memory B cells in ADA+ versus ADA- RA patients. I also assessed the predictive value of SIRPα/β expression in a longitudinal RA cohort prior to the initiation of adalimumab treatment. I showed that a frequency of less than 9.4% of SIRPα/β-expressing memory B cells predicts patients that will develop ADA, and consequentially fail to respond to treatment, with a receiver operating characteristic (ROC) area under the curve (AUC) score of 0.92. Thus, measuring the frequency of SIRPα/β-expressing memory B cells in patients prior to adalimumab treatment may be clinically useful to identify a subgroup of active RA patients who are going to develop an ADA response and not gain substantial clinical benefit from this treatment. Secondly, further mining of the results from the LEGENDScreenTM has allowed me to identify a signature of RA. Comparison of HCs to RA patients identified 16 differentially expressed markers associated with RA, and not with disease activity or treatment. Validation in an independent cohort determined that the combined expression of CD97, CD170 and CD11c on B cells may identify individuals that are at risk of developing RA. Thirdly, I have identified a novel marker of Bregs. Here I show that CD19hiCD170hi B cells capture the majority of IL-10 producing B cells. This subset and not its negative counterpart (CD19+CD170int/low) suppress IFNγ and IL-17 production by CD4+ T cells, in an IL-10 and CD170 dependent manner. CD19hiCD170hi B cells are numerically reduced and functionally defective in RA patients. Preliminary data suggests that the aberrant production of IL-10 by Bregs in RA patients could be attributed to a defect in CD170 recycling. I propose CD170 may aid future immunological studies of Bregs, and that targeting CD170 therapeutically could improve disease in RA
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