1,720,967 research outputs found
Intermittierende Tieftonschwerhörigkeit nach wiederholter Anwendung von Moxifloxacin-Augentropfen
No full textIntermittierende Tieftonschwerhörigkeit nach wiederholter Anwendung von Moxifloxacin-Augentropfen
No full textThere is no intraocular affection on a SARS-CoV-2 - Infected ocular surface
No full textOpen-Access-Publikationsfonds 202
Reorganization of the perifoveal microvasculature after macular hole closure assessed via optical coherence tomography angiography
No full textReliability of Subjective Assessment of Spectral-Domain OCT Pathologic Features by Multiple Raters in Retinal Vein Occlusion
No full textPURPOSE: To examine the interrater and intrarater reliability of qualitatively and quantitatively assessed disorganization of retinal inner layers (DRIL) and disorganization of retinal outer layers (DROL) by multiple raters. Subjectively assessing these surrogate biomarkers can be challenging in daily routine, despite the high resolution of spectral-domain (SD) OCT scans. DESIGN: Retrospective trial. PARTICIPANTS: Three hundred six pooled SD OCT scans of 34 patients treated for macular edema caused by retinal vein occlusion (RVO) between January 2016 and December 2017. METHODS: SD OCT scans were assessed by 6 raters regarding presence of cystoid macular edema, subretinal fluid (SRF), vitreoretinal traction, and epiretinal membrane and extent of DRIL and DROL. MAIN OUTCOME MEASURES: Interrater and intrarater reliability were calculated applying κ statistics for qualitative assessment regarding each pathologic feature’s presence in all evaluated OCT scans, and for quantified horizontal DRIL and DROL extent within each OCT cross-section. RESULTS: Cystoid macular edema and SRF assessments revealed excellent inter- and intrarater reliability with almost perfect strength of agreement, whereas subjective DRIL and DROL evaluations yielded low κ statistics with slight to moderate strength of agreement. Furthermore, the presence of SRF remarkably compromised the reliability of DROL detection. CONCLUSIONS: Our data highlight the limited subjective assessibility of DRIL and DROL, underscoring the need for automated image analysis to improve the reliability of OCT biomarkers for clinical studies and daily practice
Risk factors for severe bleeding complications in glaucoma surgery and the role of antiplatelet or anticoagulant agents
Full text linkPurpose: To evaluate the influences and risk factors for severe bleeding complications during glaucoma surgery, and to investigate the
role of antiplatelet (AP) and anticoagulant (AC) agents.
Methods: This prospective study enrolled patients undergoing trabeculectomy, trabeculotomy (with Trabectome® or Kahook Dual
Blade®), viscocanaloplasty and Ahmed or Baerveldt implants. Bleeding severity was graded on an ordinal scale ranging from 0 to 5.
Immediately after surgery and one day later, the incidence and severity of bleeding events was documented on a standardized form. A grade
≥3 was defined as severe bleeding. The influence of known systemic disorders, the type of anesthesia, surgical procedure, intraoperative
blood pressure, and the use of or change in AP or AC agents on intraoperative bleeding were analyzed.
Results: Data from 89 eyes undergoing glaucoma procedures were included (age 71.3y ± 10.5). We observed severe intraoperative
bleeding in 8 eyes (9%) and found that concomitant diseases such as the history of a deep vein thrombosis or peripheral arterial
occlusive disease, and the type of surgical procedure (trabeculectomy and viscocanaloplasty) were significantly associated with severe
bleeding events. By contrast, the use of AP/ AC agents had no significant influence on severe intraoperative bleeding events.
Conclusion: According to the results of our study cohort, glaucoma procedures entailing scleral manipulations (trabeculectomy and
viscocanaloplasty) and concomitant diseases such as the history of a deep vein thrombosis or peripheral arterial occlusive disease
influence the risk of severe intraoperative bleeding events, we detected no increased risk related to concomitant antiplatelet and/ or
anticoagulant medication use.Open-Access-Publikationsfonds 202
Distance-Thresholded Intercapillary Area Analysis Versus Vessel-Based Approaches to Quantify Retinal Ischemia in OCTA
No full textInfluence of pars plana vitrectomy for macular surgery on the medium term intraocular pressure.
No full textPurposeTo evaluate the long-term effect of 20 and 23 gauge pars plana vitrectomy (PPV) on intraocular pressure (IOP).MethodsStudy type: Monocentric retrospective cohort study. 249 eyes of 249 patients undergoing PPV due to epiretinal membrane (EM), idiopathic macular hole (IMH) or vitreoretinal traction (VT) were included. The fellow eye served as control. Exclusion criteria were factors known to influence the IOP, such as cataract surgery during follow-up, extended use of steroids, cryotherapy and silicone oil endotamponade. The relative change of IOP (operated vs. fellow eye) at 6-12 months after surgery was defined as primary endpoint. Secondary endpoints were the relative change of IOP at 3-6 and 12-24 months. Possible influencing cofactors were analysed using ANCOVA.ResultsThe primary endpoint did not show a significant IOP reduction of the operated eye relative to the fellow eye (P = 0.089, n = 84). However, the IOP of the operated eye alone was significantly reduced at 6-12 and 12-24 months after surgery (-0.75 ± 2.80 and -1.22 ± 3.29 mmHg, P = 0.008 and 0.007, respectively). The IOP of the fellow eye was also significantly reduced at the 12-24 months period (-0.75 ± 2.73 mmHg, P = 0.008). In the subgroup analysis, sclerotomy size was a significant influencing cofactor, leading to lower IOP after 20G compared to 23G vitrectomy (P = 0.04).ConclusionPars plana vitrectomy did not induce a significant long-term IOP reduction relative to the contralateral eye. However, we observed a IOP lowering potential in 20G vitrectomy
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
