61 research outputs found
A sentimental journey through France and Italy [electronic resource] : By Mr. Yorick. with an account of the author's life. To which are added several pieces by the same author. Complete in four volumes.
No full textMr. Yorick = Laurence Sterne.Titlepage to vols. 3,4,: 'Yorick's sentimental journey through France and Italy. Continued by Eugenius. .., i.e. John Hall Stevenson.In two sequences of pagination and register.With an 'Appendix: containing several pieces written by the author of the 'Sentimental Journey.'.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Population pharmacokinetic and pharmacodynamic properties of intramuscular quinine in Tanzanian children with severe Falciparum malaria.
No full textAlthough artesunate is clearly superior, parenteral quinine is still used widely for the treatment of severe malaria. A loading-dose regimen has been recommended for 30 years but is still often not used. A population pharmacokinetic study was conducted with 75 Tanzanian children aged 4 months to 8 years with severe malaria who received quinine intramuscularly; 69 patients received a loading dose of 20 mg quinine dihydrochloride (salt)/kg of body weight. Twenty-one patients had plasma quinine concentrations detectable at baseline. A zero-order absorption model with one-compartment disposition pharmacokinetics described the data adequately. Body weight was the only significant covariate and was implemented as an allometric function on clearance and volume parameters. Population pharmacokinetic parameter estimates (and percent relative standard errors [%RSE]) of elimination clearance, central volume of distribution, and duration of zero-order absorption were 0.977 liters/h (6.50%), 16.7 liters (6.39%), and 1.42 h (21.5%), respectively, for a typical patient weighing 11 kg. Quinine exposure was reduced at lower body weights after standard weight-based dosing; there was 18% less exposure over 24 h in patients weighing 5 kg than in those weighing 25 kg. Maximum plasma concentrations after the loading dose were unaffected by body weight. There was no evidence of dose-related drug toxicity with the loading dosing regimen. Intramuscular quinine is rapidly and reliably absorbed in children with severe falciparum malaria. Based on these pharmacokinetic data, a loading dose of 20 mg salt/kg is recommended, provided that no loading dose was administered within 24 h and no routine dose was administered within 12 h of admission. (This study has been registered with Current Controlled Trials under registration number ISRCTN 50258054.)
A Mirror for Mankind: The Pose of Hamlet with the Skull of Yorick
No full textThis essay proposes to discuss what I shall call the pose of Hamlet with the skull of Yorick as a motif of special significance in poetry and art. My sense of “motif” here is similar to what George Steiner has called a “topology of culture.” Drawing metaphorically on “the branch of mathematics which deals with those relations between points and those fundamental properties of a figure which re- main invariant when that figure is bent out of shape,” Steiner argues that there are also such “invariants and constants underlying the manifold shapes of expression in our culture.” This notion of cultural topologies grows out of Steiner’s sense that culture is to a large degree “the translation and rewording of previous mean- ing”(415). The motif of the pose of Hamlet involves in its different manifestations all three of Roman Jakobson’s categories of translation: intralingual, interlingual, and especially intersemiotic.This essay first appeared in The New Orleans Review 17.3 (Fall 1990).Peer reviewe
ispg-group/optimwidths: Version used for the AIMSWISS paper
No full textA script for calculating the Gaussian width parameter of AIM
To Which Is Added, The Life Of The Author Written By Himself
No full textBy Mr. Yorick ; With A Continuation By Eugenius ; To Which Is Added, The Life Of The Author Written By HimselfAuf vorderem Spiegel Etikette: "Universität Basel - Geschenk von Frau Bürgermeister R. Sarasin-Brunner. 1872." 21.10.2020/A100/HP
Assessing Nonadiabatic Dynamics Methods in Long Timescales
No full textIn this study, we employ the multiconfiguration time-dependent Hartree (MCTDH) and its multi-layer variants (ML-MCTDH), ab initio multiple spawning (AIMS), and fewest-switches surface hopping (FSSH) methodologies to simulate the excited-state dynamics of a weakly-coupled multi-dimensional (10 dimensional) Spin-Boson model Hamiltonian designed for a long timescale decay behavior. The pre-print of the article can be found at https://chemrxiv.org/engage/chemrxiv/article-details/66f68454cec5d6c142647b0a MUKHERJEE S, Lassmann Y, Mattos RS, Demoulin B, Curchod BFE, Barbatti M. Assessing Nonadiabatic Dynamics Methods in Long Timescales. ChemRxiv. 2024; doi:10.26434/chemrxiv-2024-j7xxl The dataset contains MCTDH.tar.bz2 - 10 sets of text files for MCTDH simulations ML-MCTDH.tar.vz2 - 10 sets of text files for ML-MCTDH simulations DC-FSSH.tar.bz2 - HDF5 output files for 2000 independent decoherence-corrected FSSH trajectories and a Python script for Wigner Sampling initial conditions CSS-AIMS.tar.gz - output text files for 44 independent cannibalistic stochastic selection approach of AIMS trajectorie
A Sentimental Journey : Through France And Italy
No full textBy Mr. Yorick : With A Continuation By Eugenius ; To Which Is Added, The Life Of The Author Written By HimselfMutmasslich von Wilhelm Haas d.J. im Auftrag von Legrand gedrucktIllustration: fiktives Wappen von "Mr. Yorick
Forecast of the dynamic behaviour of FRP footbridges: Vibrations induced by pedestrians
No full textFibre reinforced polymer (FRP) is a new construction material that often is used for pedestrian bridges. It offers a good strength-weight relation, a long-term durability and slender bridge shapes. Slenderness has effect on dynamic behaviour of the construction and vibrations are common for these bridges. Hand calculations are commonly used for the forecast of the dynamic behaviour, but this approach is not very accurate. Royal Haskoning DHV felt the need for a numerical model to be able to forecast the dynamic behaviour of pedestrian bridges of which accelerations, natural frequency and damping ratio are the most important. This thesis aims to fulfil this need. During a literature study relevant calculation methods were found and offered a better insight in the behaviour of bridges and the properties of FRP. FiberCore, manufacturer of FRP bridges, provided information of 15 different bridges all over the Netherlands. These bridges were all examined and vibrations were measured in the field. It was possible to bring 7 of these bridges in vibration using two test methods. To be able to measure accelerations and natural frequency mobile applications were validated in a case study in Puurs Belgium with the University of Leuven. A numerical model has been built for one specific bridge with a finite element method in SOFiSTiK and validated with the information provided by FiberCore. Furthermore, a dynamic load simulating a person walking over the bridge was designed. After having validated the model calculations were made to determine the natural frequency and the accelerations of this bridge as well without as with handrails. The results were compared with hand calculation according to the calculation method of the Joint Research Centre (JRC). Significant differences between the results of the model calculation and the JRC method were found and analysed. The main conclusions of the thesis are regarding the damping factor and the results from the numerical model. The damping factor of 1.4% to 5.4% is measured for 8 FRP bridges spanning 10-25m. The assumption of 1% damping, which is often used in design verifications in engineering practice is conservative. The maximum acceleration from the numerical model, 1.22 m/s2, is higher than the 0.43 m/s2 calculated from the SDOF method from the JRC, which is used in design verifications in engineering practice. The psi factor is a very dominant reduction in the latter calculation. The author concludes with some recommendations for further research.Civil Engineerin
Probing the sensitivity of ab initio multiple spawning to its parameters
No full textFull multiple spawning (FMS) offers a strategy to simulate the nonadiabatic dynamics of molecular systems by describing their nuclear wavefunctions by a linear combination of coupled trajectory basis functions (TBFs). Applying a series of controlled approximations to the full multiple spawning (FMS) equations leads to the ab initio multiple spawning (AIMS), which is compatible with an on-the-fly propagation of the TBFs and an accurate description of nonadiabatic processes. The AIMS strategy and its numerical implementations, however, rely on a series of user-defined parameters. Herein, we investigate the influence of these parameters on the electronic-state population of two molecular systems— trans-azomethane and a two-dimensional model of the butatriene cation. This work highlights the stability of AIMS with respect to most of its parameters, underlines the specific parameters that require particular attention from the user of the method, and offers prescriptions for an informed selection of their value.</p
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