99 research outputs found
Episode 1: Friction and Flow – Comparing and Contrasting Clausewitz’ and Sun Tzu’s Theories of War
No full textGuests Vanya Bellinger and Andrew Dex Wilson join host Brendan Neagle to compare and contrast the foundational theorists of war: Clausewitz and Sun Tzu.
Guests:
Andrew R. Wilson is the John A. van Beuren Chair of Asia-Pacific Studies. Professor Wilson has lectured at military colleges and civilian universities across the United States and around the world. The author of a number of books and articles on Chinese military history, Chinese sea power and Sun Tzu\u27s “The Art of War,” he is presently at work on “The Acme of Skill: Strategic Theory from Antiquity to the Information Age.” Professor Wilson is also featured on “The Great Courses,” with lecture series including “The Art of War”; “Masters of War: History’s Greatest Strategic Thinkers”; and “Understanding Imperial China: Dynasties, Life and Culture.”
Vanya Eftimova Bellinger earned a Ph.D. in history at King’s College, London. Bellinger is the author of Marie von Clausewitz: The Woman Behind the Making of On War (Oxford University Press USA, 2015). She is the winner of the 2016 Society for Military History Moncado Prize for her article, “The Other Clausewitz: Findings from the Newly Discovered Correspondence between Marie and Carl von Clausewitz.” Bellinger is the first scholar to work with the newly discovered correspondence between the Clausewitz couple. Before transitioning to academia, Bellinger worked as a journalist and international correspondent for various European outlets.https://digital-commons.usnwc.edu/strategy-matters/1000/thumbnail.jp
Vanderbilt Business; Spring 2010
No full textVanderbilt Business serves as the magazine for the students, faculty, alumni, and friends of the Owen Graduate School of Management.Vanderbilt University. Alumni AssociationCONTENTS **
Page 2 PERSONAL ASSETS
Durégo Lewis, BSâ 96, EMBAâ 06, finds
success through teamwork
by SETH ROBERTSON **
Page 10 STUDENT EXPERIENCE
BrandWeek Louisville offers students a
practitionerâ s perspective on marketing
by BRIAN BELLINGER **
Page 12 BUSINESS ROUNDTABLE
A conversation with Chad Holliday,
Chair of the Board of DuPont **
Page 18 INFORMED OPINION
Treat health insurance like auto insurance
and hold people accountable
by LARRY VANHORN **
Page 30 CORPORATE SPOTLIGHT
Dan Proctor, MBAâ 83, seeks a new
challenge in Uganda
by SETH ROBERTSON **
Page 37 IN THE NEWS
Headlines from around the world **
Page 53 CAMPUS VISIT
Q&A with Melinda Allen, Executive Director
of the Leadership Development Program **
Page 56 BOTTOM LINE
Broadening studentsâ thinking through
nonbusiness reading
by JIM BRADFORD **
ON THE COVER
David Ingram, MBAâ 89
Photo by JOHN RUSSELLVanderbilt University. Owen Graduate School of Managemen
Central Washington University Football, Larry Bellinger Biography
No full texthttps://digitalcommons.cwu.edu/cwu_football/1144/thumbnail.jp
1952 Men's Basketball Team Northwest Conference Champions
No full textnames included on photo: Basketball; Lewis, Coach Johnny; Scrivens, Lou; Smith, Larry; Girod, Daryl; Shepard, Robert; Hoy, Richard; Logue, Doug; Loder, Ted; Williams, Ray; Gilson, Layton; Smith, Robert; Mase, Richard; Brouwer, Richard; Bellinger, Hugh; Holt, Benny; Weber, Erwin, Mgr.; Wilson, Howard, Mgr.Black and Whit
Episode 10: World War on the Peripheries: Strategic Lessons from Colonial Theaters in WWI
No full textEpisode ten of Strategy Matters aligns with the fourth case study in the Strategy and Policy Course at the Naval War at the U.S. Naval War College. Much of the case study focuses on the European theaters of World War I, but in the podcast, we are exploring the extra-European or colonial theaters of the conflict. Although distinct, they were seldom decisive. Nonetheless, the colonial theaters in WWI hold many lessons for today’s strategists, including the complexities of peripheral theaters and irregular warfare, the role of seapower in a global conflict, and recruitment and motivation to fight. The host, Dr. Vanya Eftimova Bellinger, is joined by two professors from the Strategy and Policy Department: Dr. Tim Hoyt and Dr. Jesse Tumblin. A renowned expert on irregular warfare, Dr. Hoyt examines why, despite much action in the colonial theaters, they failed to break the stalemate or shift the balance between the belligerents. A historian of the British Empire, Dr. Tumblin discusses how the dominions provided it with manpower and enormous resources, but also challenged the empire’s institutions and war strategy.
The opinions expressed on this podcast represent the views of the presenters and do not reflect the official position of the Department of War, The US Navy, or US Naval War College.
Guests:
Dr. Timothy Hoyt, Ph.D.is the John Nicholas Brown Chair of Counterterrorism and, since 2019, has also served as the Director of the Advanced Strategy Program at the U.S. Naval War College. He is the author of numerous publications on irregular warfare, COIN and counterterrorism, and South Asia. Dr Hoyt also serves as the Deputy Editor of The Journal of Strategic Studies.
Dr. Jesse Tumblin, Ph.D.is an assistant professor of strategy and policy specializing in political and military history, ideas of security, and the current and former British world. He earned a Ph.D. and M.A. from Boston College and a B.A. from the University of Tennessee. He is a past fellow in international security studies at Yale University. He is the author of “The Quest for Security: Sovereignty, Race, and the Defense of the British Empire, 1898-1931” (Cambridge University Press, 2020) and an article on Britain’s attempts to secure its Indo-Pacific empire, which won the Saki Ruth Dockrill Memorial Prize for international history from the Institute for Historical Research, University of London.https://digital-commons.usnwc.edu/strategy-matters/1009/thumbnail.jp
Episode 3: Strategic Leadership Matters: Demosthenes and Brasidas in the Peloponnesian War
No full textGuests Michael Pavković and Josh Hammond join host Vanya Eftimova Bellinger to profile the strategic leadership of two of the most compelling figures of the Peloponnesian War: Demosthenes and Brasidas. They compare Brasidas’s formative experiences in Sparta with Demosthenes’s in Athens, exploring how these backgrounds shaped each man’s approach to strategic leadership. The discussion highlights key qualities of effective strategic leaders, including the ability to balance boldness with prudence, exceptional creative and critical thinking skills, and the capacity to reassess, adapt, and decide faster than the adversary. A central theme is the adaptability required to transition from a successful tactical commander to an effective strategist. Careful listeners will also enjoy a surprisingly apt Guns N’ Roses analogy.
Guests
Professor Michael F. Pavković currently serves as Vice Admiral William Ledyard Rodgers Professor in Naval History in the Strategy and Policy Department at the college. He received his B.A. in history and classics from Pennsylvania State University and his Ph.D. in history from the University of Hawai‘i at Mānoa. He has presented papers at national and international conferences and has also published a number of articles, book chapters and reviews on topics relating to ancient, early modern and Napoleonic military history. He is co-author of What is Military History? (Polity Press, 3rd edition, 2017). He is currently writing a book on sea power in the ancient world.
Cmdr. Josh Hammond graduated from the University of Michigan with a B.A. in classical languages and the U.S. Naval War College with an M.A. in national security and strategic studies. While at NWC, he received the Adm. Richard G. Colbert Memorial Prize for professional writing and research. A career naval flight officer, he has over 2,300 hours and 500 carrier landings in the F-14D and F/A-18F in support of numerous operations in the Arabian Gulf and Western Pacific. Other assignments include air operations officer on USS Carl Vinson and an exchange assignment with the Royal Navy in carrier doctrine development.https://digital-commons.usnwc.edu/strategy-matters/1002/thumbnail.jp
Effects of Xylitol and Stimulated Salivary Flow on Calculus Accumulation in Gastrostomy Tube-Fed Patients: A Pilot Study
No full textThis pilot study was initiated to investigate whether xylitol and/or stimulated salivary flow would have an effect on the accumulation of calculus in gastrostomy tube-fed patients. Following stringent inclusion criteria and 33% patient drop-out, four patients completed at least one of the two interventions after an initial baseline period. Intervention #1 consisted of using Dr. John���s�� sugar-free lollipops (Product #NMF100) three times a day for five minutes each over a period of eight weeks. Intervention #2 utilized Dr. John���s�� xylitol-containing sugar-free lollipops (Product #NMXF100, 1 gram of xylitol per lollipop) three times a day for five minutes each over a period of eight weeks. Intra-oral photographs of the buccal surfaces of the maxillary first permanent molars were used to determine the amount of calculus formed pre- and post-interventions. Calculus levels were determined using the Calculus Score Method and by percentage of surface area covered by calculus using Elements�� software. No significant differences were found comparing either post-intervention calculus levels to pre-intervention baseline calculus levels. Also no significance was found between Intervention #1 and #2. The extremely low patient enrollment and high percentage of patient drop-out render this pilot study inadequate in drawing significant conclusions
Estradiol Controls Varicella Zoster Virus Associated Nociception through Gabaergic Thalamic Signaling Mechanism
No full textPost-Herpetic Neuralgia (PHN), a chronic pain condition resulting from Herpes Zoster (HZ), is reported by females 3.75 times more often than men. Investigating the role of estradiol in thalamic gene expression, neuronal activity in the ventral posteromedial thalamus (VPM) and the Varicella Zoster Virus (VZV) associated pain response, can contribute to identifying mechanisms in which estradiol modulates the orofacial nociceptive processes of PHN and contributes to this disparity. VZV was injected into the whisker pad of adult Sprague Dawley rats. Changes in orofacial nociception and the affective nociceptive response, i.e. place escape avoidance paradigm (PEAP) were measured. Local field potentials (LFPs) of the VPM were recorded simultaneously while inhibiting neuronal activity to investigate its effects on the VZV associated nociception response.
Gene expression changes in cycling SD rats was analyzed by RT-PCR. Plasma estradiol levels were measured at different phases of the estrous cycle to monitor changes in thalamic gene expression during periods of low and high estradiol and identify key genes that modulate VZV associated nociception through estradiol induced changes in thalamic gene expression. Vesicular GABA Transporter (VGAT) expression was attenuated in the thalamus by injecting a VGAT silencing shRNA and the VZV associated nociception response was measured in both male and female rats. As seen in human PHN, infected rats showed neurite retraction in the whisker pad, translocation of VZV to neurons in the trigeminal ganglia (as evident by IE62 staining) and gabapentin amelioration of the nociceptive response. Increases in thermal hyperalgesia, mechanical allodynia and PEAP were observed. Female rats showed a longer VZV associated affective response than males and when plasma estradiol concentrations were decreased, the affective response to VZV injection increased. In ovariectomized rats with hormone replacement, estradiol levels mirroring the proestrus phase of the natural cycle, reduced VZV associated nociception. The expression of VGAT was significantly increased in the lateral thalamus during the high estrogen phases (proestrus and estrus) of the estrus cycle. After VGAT silencing in the lateral thalamus, VZV associated nociception significantly increased in both male and female rats. Altogether exhibiting that estradiol controls VZV associated pain through VGAT GABAergic thalamic signaling
Dynorphin Promotes Comorbid Migraine-like Pain in Female Mice with Temporomandibular Joint Disorders
No full textMigraine is a prevailing type of neurological disorder and is frequently found coexisting with temporomandibular disorders (TMD) in the same individual, especially in the patients with myogenic TMD. Both conditions have a higher prevalence in women than in men. Despite the economic burden and health adverse effects caused by migraine and TMD, the complex pathophysiologic mechanisms underlying the coexisting of migraine and TMD are still not well studies and remain elusive.
In the present study, we first employed masseter muscle tendon ligation (MMTL) procedure to generate a myogenic TMD model in mice, later we found this MMTL injury can promote the occurrence of the nitroglycerin (NTG)-induced migraine-like hypersensitivity and prolong this hypersensitivity after the onset. We characterized this MMTL-enhanced migraine-like hypersensitivity model with measuring the mechanical head withdrawal threshold in masseter and periorbital area, gnawing dysfunction, and light-aversive behavior.
Using this MMTL-enhanced migraine-like hypersensitivity model, we found Prodynorphin (Pdyn) gene and its translated product dynorphin A (dynA) peptide in the spinal trigeminal nucleus caudalis (Sp5C) play critical role in promoting the onset of migraine post-MMTL injury in female mice, but not in male mice. The projection of Pdyn-expressing excitatory neurons inside Sp5C, from the mandibular (V3) area to the ophthalmic (V1) area, explains how the MMTL injury happened in masseter area (innervated by trigeminal nerve V3 branch) has an effect on the nociception in periorbital area (innervated by trigeminal nerve V1 branch).
In the further study, we found that instead of interacting with the traditional believed dynA receptor - kappa opioid receptor, dynA carried out its effect in the MMTL-enhanced migraine-like hypersensitivity by interacting with bradykinin receptor B2 (BKRB2) and N-methyl-D-aspartate (NMDA) receptors. BKRB2 regulates this periorbital hypersensitivity by trafficking to plasma membrane, decreasing BKRB2-neuronal NOS (nNOS) binding and subsequently increases nNOS enzyme activity, thereby promoting the production of neurotoxic nitric oxide (NO). NMDA receptors also enhances nNOS activity level, but through NMDA receptor-PSD95-nNOS complex signaling pathway.
In summary, the present study suggests that dynA peptide promotes comorbid migraine in specifically female TMD mice, but not male mice, through interacting with BKRB2 and NMDA receptors
Testosterone Attenuates Post Herpetic Neuralgia, in Part, by Conversion to Estradiol
No full textHerpes zoster (HZ) or Shingles is often followed by Post Herpetic Neuralgia (PHN). PHN is a chronic pain condition usually occurring a few months after the visible symptoms of HZ subside. Although Testosterone can affect pain responses, the role of testosterone in PHNs is unknown. Testosterone is converted into estrogen in certain areas including the thalamus of the brain by the enzyme aromatase. We tested our hypothesis that testosterone conversion to estrogen in thalamus attenuates HZ induced pain.
Male Sprague-Dawley rats were divided into control and virus groups receiving whisker pad injections of either MeWo cells or MeWo cells containing varicella Zoster Virus (VZV), respectively. Virus injections (100 ��l) were in the left whisker pad and contained either 60,000 pfu of virus or control. Virus and control groups were further divided in two drug groups receiving the aromatase inhibitor letrozole or the vehicle dimethyl sulfoxide (DMSO). Drug was given either locally or systemically. Guide cannulas were placed in the thalamic area for a portion of the rats using stereotaxic coordinates for local administration of drug. The conversion of testosterone into estrogen is selectively inhibited using Letrozole. The motivational and affective aspect of nociception was measured using Place Escape Avoidance Paradigm (PEAP) assay. Measurements were completed once a week for three weeks.
Data obtained were statistically analyzed and demonstrated that virus injection significantly increased the nociceptive response compared to the control. This nociceptive response was significantly increased after administration of Letrozole. In conclusion, testosterone reduces the VZV associated nociceptive response, in part, due to conversion into estrogen in the thalamic region
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