7 research outputs found
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats
No full textWe studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression,decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were:normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy.We studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression, decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were: normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy.Fil: Macova, Miroslava. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Armando, Maria Ines. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Zhou, Jin. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Tyurmin, Dmitri. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Larrayoz Roldan, Ignacio M.. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Saavedra, Juan M.. National Institute of Mental Health. Department of Health and Human Services; Estados Unido
A critical assessment of the theology of Camilo Torres in the light of Latin American theology : a theological paradigm for peace with justice for Colombia
No full textThe thesis aims to provide a critical assessment of Camilo Torres’ concept of efficacious love in the light of a hermeneutics and ethics of liberation, to contribute theoretically to theological reflection upon the mission of the Protestant and Roman Catholic churches in Colombia, and generally in Latin America. It proposes the thesis that the theology of Camilo Torres, viewed from the perspective of a hermeneutics and an ethics of liberation, can be foundational for seeking, constructing, and sustaining peace with justice in a context of oppression and violence.
Based on the theological analysis, the academic and spiritual motivation should respond to two fundamental questions in our academic inquiry: what foundation exists in Camilo Torres’ theology for the construction of a just, peaceful, liberative society and to enable proximity to the excluded, victimized, and poor population in Colombia to be achieved? And how can we as Christians respond to the grace of God in living efficaciously the values of the Kingdom of God, in order to bring structural changes in Colombia? The implications of the answers to those questions would result in the possibility to execute an integrating theological proposal for peace with justice for the church in Colombia.
In an interpretative mode, we consider critically the multidisciplinary interaction of some of the theological foundations of liberation theology. Our task consists in clarifying and constructing theological presuppositions for a dialectical examination of the historical and current situation in Colombia, viewed in the light of the internal problems and realities. Thus, it is our intention in order to attempt a significant interdisciplinary juncture, to examine and interpret such relevant concepts as efficacious love, faith with works, kenosis, hypostatic union, hermeneutics and ethics of liberation, social justice, personal and collective socio-political conversion, and a praxis of faith as the church’s mission in response to the Colombian context of poverty and violence
Discursos y prácticas sobre la naturaleza en el proyecto paramilitar (1980-2005): procesos de reforestación- deforestación en Córdoba- Urabá
No full textDiversos han sido los estudios que han abordado el paramilitarismo en Colombia. Estudios que van desde una concepción contrainsurgente del fenómeno hasta aquellos que lo posicionan como una empresa criminal acumuladora de recursos. La presente investigación posiciona el paramilitarismo como un proyecto que se despliega estratégicamente sobre los territorios. Para ello se describen los discursos y las practicas sobre la naturaleza presentes en el proyecto paramilitar desde 1980 hasta el 2005 en Urabá y Córdoba. Metodológicamente se opera desde el método arqueológico propuesto por Michel Foucault, cuyo eje central busca desentrañar las condiciones de posibilidad de una determinada formación discursiva en un tiempo-espacio específico, esto es, las relaciones entre las instituciones, prácticas, conceptos y modalidades enunciativas, elementos que se encuentran atravesados por unas dinámicas de saber-poder que movilizan el discurso mismo. Este esquema metodológico posibilitó desentrañar las relaciones entre el paramilitarismo y la naturaleza representada desde unas redes discursivas que se han tejido históricamente y que la han posicionado como un recurso apto para su apropiación-destrucción. Se evidencia entonces como el paramilitarismo se vincula a prácticas forestales determinadas por unos discursos que en el orden global se sitúan en una matriz discursiva desarrollista pero que en el orden local se entrecruza con las dinámicas del conflicto por la tierra, las economías extractivas y los proyectos sociales que sirven de fachada para los intereses de las élites locales, políticas, empresarios y narcotraficantes. Se concluye entonces que el proyecto paramilitar operó sobre unas estéticas territoriales marcadas por experiencias como el despojo sistemático y la transformación de la naturaleza en el escenario de la expansión de la frontera agropecuaria y la introducción de monocultivos.There have been diverse studies on paramilitarism in Colombia. These studies range from understanding paramilitarism as a counter-terrorist phenomenon, to analyses that position it as a criminal enterprise seeking to accumulate resources. The current study situates paramilitarism as a project that unfolds strategically over territories. In order to do so, it describes the discourses and practices related to nature that are present in the paramilitary project as seen in the regions of Urabá and Córdoba between 1980 and 2005. Methodologically, it operates using Michel Foucault‟s archeological method, which is centered on unraveling the conditions of possibility of a particular discursive formation in a specific time-space. In other words, it aims to understand the relation between institutions, practices, concepts and expository modes, elements that are permeated by knowledgepower dynamics that mobilize discourse itself. This methodological scheme allowed the author to unravel the relations between paramilitarism and nature as they are represented by discursive networks that have been historically woven to position nature as a resource available for appropriation-destruction. Hence, this paper highlights the ways in which paramilitarism is linked to specific forestry practices determined by discourses which, at a global level, are related to the “development” discursive matrix, but which, at the local level, become intertwined with dynamics of conflict over land access, extractive economies, and social projects that serve as facades for the interest of local and political elites, entrepreneurs, and drug-traffickers. This research concludes that the paramilitary project operated under territorial aesthetics marked by experiences such as systematic plunder, as well as the transformation of nature into a landscape of expansion of the agricultural and livestock frontier and the introduction of mono-cropping.Introducción ................................................................................................................ 81. Descripción del problema ................................................................................... 142. Justificación ............................................................................................................. 213. Objetivos ................................................................................................................ 244. Marco teórico – referencial ................................................................................. 25Capítulo I ................................................................................................................... 45Discursos y prácticas sobre la naturaleza en Colombia ..................................... 45Capítulo II .................................................................................................................. 72El encierro narco-paramilitar de la tierra-naturaleza ........................................... 72Capítulo III .................................................................................................................. 998. Devenir criminal del proyecto paramilitar ........................................................ 999. Conclusiones ....................................................................................................... 125PregradoLicenciado(a) en Ciencias SocialesTrabajo de Investigación/Extensió
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
No full textInterindividual clinical vari-ability is vast in humans infected withsevere acute respiratory syndrome corona-virus 2 (SARS-CoV-2), ranging from silent in-fection to rapid death. Three risk factors forlife-threatening coronavirus disease 2019(COVID-19) pneumonia have been identified—being male, being elderly, or having othermedical conditions—but these risk factorscannot explain why critical disease remainsrelatively rare in any given epidemiologicalgroup. Given the rising toll of the COVID-19pandemic in terms of morbidity and mortality,understanding the causes and mechanisms oflife-threatening COVID-19 is crucial.The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, The Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, the Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the French National Research Agency (ANR) under the Investments for the Future program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project (ANRS-COV05), the Square Foundation, Grandir – Fonds de solidarité pour l’enfance, the SCOR Corporate Foundation for Science, the Institut Institut National de la Santé et de la Recherche Médicale (INSERM), and the University of Paris. Samples from San Raffaele Hospital were obtained through the Covid-BioB project and by healthcare personnel of San Raffaele Hospital, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) clinical laboratory and clinical research unit, funded by the Program Project COVID-19 OSR-UniSR and Fondazione Telethon. The French COVID Cohort Study Group was sponsored by INSERM and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). The Cov-Contact Cohort was supported by the REACTing consortium, the French Ministry of Health, and the European Commission (RECOVER WP 6). The Milieu Intérieur Consortium was supported by the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence Milieu Intérieur grant (ANR-10-LABX-69-01) (primary investigators: L.Q.-M. and D.Du.). The Simoa experiment was supported by the PHRC-20-0375 COVID-19 grant “DIGITAL COVID” (primary investigator: G.G.). S.G.T. is supported by a Leadership 3 Investigator Grant awarded by the National Health and Medical Research Council of Australia and a COVID19 Rapid Response Grant awarded by UNSW Sydney. C.R.-G. and colleagues were supported by the Instituto de Salud Carlos III (COV20_01333 and COV20_01334, Spanish Ministry of Science and Innovation RTC-2017-6471-1; AEI/FEDER, UE) and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”). S.T.-A. and A.B. were supported by ANR-20-COVI-0064 (primary investigator: A.Be.). This work is supported by the French Ministry of Health “Programme Hospitalier de Recherche Clinique Inter regional 2013,” by the Contrat de Plan Etat-Lorraine and FEDER Lorraine, and by a public grant overseen by the French National Research Agency (ANR) as part of the second Investissements d’Avenir program FIGHT-HF (reference no. ANR-15-RHU-0004) and by the French PIA project “Lorraine Université d’Excellence” (reference no. ANR-15-IDEX-04-LUE) (45); and biobanking is performed by the Biological Resource Center Lorrain BB-0033-00035. This study was supported by the Fonds IMMUNOV, for Innovation in Immunopathology; by a grant from the Agence National de la Recherche (ANR-flash Covid19 “AIROCovid” to F.R.-L.); and by the FAST Foundation (French Friends of Sheba Tel Hashomer Hospital). Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1; a George Mason University Fast Grant; and the G. Harold and Leila Y. Mathers Charitable Foundation. The Amsterdam UMC Covid-19 Biobank was supported by grants from the Amsterdam Corona Research Fund, the Dr. C.J. Vaillant Fund, and the Netherlands Organization for Health Research and Development [ZonMw; NWO-Vici-Grant (grant no. 918·19·627 to D.v.d.B.)]. This work was also supported by the Division of Intramural Research of the National Institute of Dental Craniofacial Research and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by Regione Lombardia, Italy (project “Risposta immune in pazienti con COVID-19 e comorbidita”). The opinions and assertions expressed herein are those of the author(s) and do not necessarily reflect the official policy or position of the Uniformed Services University or the Department of Defense. J.H. holds an Institut Imagine M.D.-Ph.D. fellowship from the Fondation Bettencourt Schueller. J.R. is supported by the INSERM Ph.D. program (“poste d’accueil Inserm”). P.Ba. was supported by the French Foundation for Medical Research (FRM, EA20170638020) and the M.D.-Ph.D. program of the Imagine Institute (with the support of the Fondation Bettencourt-Schueller). We thank the Association “Turner et vous” for their help and support. Sample processing at IrsiCaixa was possible thanks to the crowdfunding initiative YoMeCorono. D.C.V. is supported by the Fonds de la recherche en santé du Québec clinician-scientist scholar program. K.K. was supported by the Estonian Research Council grant PUT1367. We thank the GEN-COVID Multicenter Study (https://sites.google.com/dbm.unisi.it/gen-covid). We thank the NIAID Office of Cyber Infrastructure and Computational Biology, Bioinformatics and Computational Biosciences Branch (contract no. HHSN316201300006W/HHSN27200002 to MSC, Inc.), the Operations Engineering Branch for developing the HGRepo system to enable streamlined access to the data, and the NCI Advanced Biomedical Computational Science (ABCS) for data transformation support. Biomedical Advanced Research and Development Authority was supported under contract no. HHSO10201600031C (to J.H.). Financial support was provided by the National Institute of Allergy and Infectious Diseases (NIAID) K08AI135091; the Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; and the American Academy of Allergy, Asthma, and Immunology
The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV-infected patients
No full textDr. Fred Stephen Sarfo, The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV-infected patients. PhD dissertation, Durham University, January 2013.
Introduction: In sub-Saharan Africa, HIV treatment is initiated with combination of antiretroviral medications comprising of a backbone of either stavudine or zidovudine plus lamivudine with a non-nucleoside reverse transcriptase inhibitor of either efavirenz or nevirapine. Efavirenz is highly efficacious, durable and well tolerated. The risk for toxicity of efavirenz is determined by several factors including single nucleotide polymorphisms in the hepatic enzymes responsible for its metabolism and concurrently administered medications such as antimalarials, which share common metabolic pathways. The aims of this dissertation are to assess the long-term effectiveness of efavirenz-based antiretroviral therapy and the impact of pharmogenomics and pharmacokinetic interactions of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV-infected patients.
Methods: The effectiveness of efavirenz- compared with nevirapine-based antiretroviral therapy was assessed retrospectively in nearly 4000 patients starting treatment between 2004 and 2010. The main outcome measure was a composite of toxicity, disease progression and attrition, and CD4 count changes. A prospective pharmacokinetic study of artesunate and efavirenz was conducted among 22 HIV-infected and 21 controls. Plasma efavirenz and artesunate/ dihydroartemisinin concentrations were measured using validated and standardised methods. Genotyping for single nucleotide polymorphisms in CYP2B6 G516T, T983C; CYP2A6*9B, UGT2B7*735 and *802 as well as CAR rs2307424 were performed for 800 patients with real-time polymerase chain reaction with allelic discrimination.
Results: Antiretroviral therapy was associated with robust CD4 increases. Efavirenz was comparable with nevirapine in composite outcomes but better tolerated. Artesunate was well tolerated when administered to HIV-infected patients on efavirenz. Single nucleotide polymorphisms in the CYP2B6 G516T and T983C were associated with increased plasma efavirenz concentrations.
Conclusions/Recommendation: Among this Ghanaian cohort, both efavirenz and nevirapine-based antiretroviral therapy were effective. The better tolerability of efavirenz compared with nevirapine means it can be safely used as the preferred first line non-nucleoside reverse transcriptase inhibitor in sub-Saharan Africa
Freight trip production and attraction for large urban generators
No full textDía a día en las ciudades se procesan, intercambian y consumen productos, todos ellos siguen una cadena de suministro iniciada, en general, en un lugar distinto al de su consumo final. Debido a esto, se generan una serie de viajes para transportar los productos desde su origen hasta el consumidor final. En gran parte de estas cadenas de suministros se emplean lugares que por sus características de operación exigen un gran movimiento de viajes de mercancías, estos lugares son referidos en la literatura como Grandes Generadores de Viajes de Carga LFTG (por sus siglas en inglés Large Freight Traffic Generators); ejemplos de estos grandes generadores de viajes de carga son algunas grandes fábricas, hospitales, plazas de mercado, hoteles, entre otros. Los LFTG urbanos pueden entenderse entonces como lugares en los que se congrega (origen o destino) un gran número de viajes de carga en un área urbana (más de 20 viajes de carga al día).
Esta investigación estima los viajes de carga generados por los LFTG urbanos. Para llevarla a cabo, el autor analiza variables que explican la producción y la atracción de los viajes de carga generados por los LFTG utilizando técnicas de regresión lineal y no lineal, la investigación tiene un enfoque cuantitativo, que busca comprender las variables asociadas con la generación de viajes por diferentes tipos de LFTG a través de los datos, variables estadísticamente significativas y conceptualmente válidas (e.g., empleo, áreas de establecimiento, número de habitaciones en hoteles, locales comerciales). Para esto se utiliza información primaria y secundaria obtenida en el Estudio de Transporte de Carga 2018 del Área Metropolitana del Valle de Aburrá, Colombia y desarrollado por la Universidad Nacional de Colombia, Sede Medellín.
Los resultados de este estudio mostraron que todos los modelos escogidos como los mejores para explicar el fenómeno de generación de viajes poseen variables significativas, por lo tanto, se puede afirmar que cambios en dichas variables independientes afectan la variable explicada.
Este estudio proporciona una herramienta para el desarrollo de políticas de movilidad en áreas urbanas e iniciativas de transporte de carga (e.g., administración de infraestructura, administración de tráfico) que tienen por objeto reducir las externalidades negativas del transporte asociado con LFTG como la congestión y el ruido.Every day, goods in cities are being processed, exchanged and consumed. Generally, all of these product’s supply chain begins in a different place from where they are finally consumed. So, a series of trips are generated to transport all of these goods from its origin to its destination. Most of these supply chains, use places with such operational characteristics as great movement of commodity trips, which are known in the literature as Large Freight Traffic Generators (LFTG); some examples could be large factories, hospitals, market places, hotels and many others. Urban LFTG can be understood as places where a large number of trips (more than 20 freight trips per day) in both origin and destination are gathered in an urban zone.
This investigation focuses on estimate freight trips generated by urban LFTG. In order, to carry it out, the author analyzes variables that explain both production and attraction of freight trips generated by LFTG using linear and non-linear regression techniques, the present investigation has a quantitative approach that looks forward to understand variables associated with the trip generation caused by different types of LFTG based on the data, statistically significant and conceptually valid variables such as employment, establishment areas, number of rooms in hotels and commercial premises. To accomplish this part, primary and secondary information obtained from the 2018 Freight Transportation Study of the Metropolitan Area of Valle de Aburrá, Colombia and developed by the National University of Colombia, Medellín Headquarters, was used.
The results of this investigation, found out that all the models chosen as the best to explain the trip freight generation phenomenon, have significant variables. Thus, it can be stated that changes in these independent variables affect the explained variable.
This study provides a tool for the development of mobility policies in urban areas and freight transport initiatives (e.g., infrastructure management, traffic management) that aim to reduce the negative externalities of transport associated with LFTG such as congestion and noise.Maestrí
Narratives on education and disability within a territory transversed by armed conflict
No full textilustraciones, diagramas, fotografíasEsta tesis es un esfuerzo personal, colectivo, ético, político y sentido que busca reivindicar las voces de diecisiete personas relacionadas con la educación de niñeces discas en el Caguán (Colombia), para generar procesos movilizadores que logren liberar y transformar sentipensares al respecto. Mi propósito como autora de este estudio fue recorrer y re-construir, de su mano, las narrativas y experiencias que ellas tienen sobre la educación y la discapacidad en el municipio de San Vicente del Caguán, procurando poner siempre en el centro las voces de las niñeces y juventudes, las madres, los padres, las maestras y los maestros que cohabitan en el territorio. Desde un enfoque crítico que bebe de una perspectiva territorial y decolonial, quise reconocer sus relatos profundamente a partir de una metodología primordialmente narrativa en donde, partiendo del interaccionismo conversacional, caminamos, nos apropiamos, cuestionamos y resignificamos los sentidos y concepciones sobre la discapacidad y la educación que circulan en tierras sanvicentunas. Especialmente, con la intención de gestar y sostener reflexiones que aporten a los espacios de decisión sobre educación y discapacidad que tienen lugar en San Vicente del Caguán, sobre todo en espacios políticos, históricos, sociales y culturales relevantes. (Texto tomado de la fuente).This thesis is a political, ethical, affective, personal, and collective effort that seeks to vindicate the voices of seventeen people who are related with the education of crip and disabled childhoods in the Caguán municipality of Colombia, trying to instil mobilising processes there that bring liberation and transformation to various thoughts and feelings around such a topic. My goal as the primary author of this research was to roam around and re-construct, alongside them, their narratives and experiences on education and disability within that context, always striving to put at the forefront the voices of the children, the youngsters, the mothers, the fathers, and the teachers who cohabitate in San Vicente del Caguán. Assuming a situated position that is based on, both, a territorial and decolonial perspective, I wanted to deeply recognise their accounts on that matter using the approach of conversational interactionism, with which we walked, appropriated, questioned, and re-signified the meanings and conceptions about disability and education that tend to circulate within the region. All with the intention to whelp critical reflections that can contribute to decision-making scenarios in San Vicente del Caguán, especially in political, historical, social, and culturally relevant spaces.MaestríaMagíster en Discapacidad e Inclusión SocialEste estudio sigue un método cualitativo y se enmarca en una aproximación superficial del enfoque
interpretativista de las políticas públicas de educación y discapacidad, a partir de las narrativas, ya que
estos permiten el estudio de la formación y transformación de un sujeto como entidad cultural histórica
(producto del cambio constante en la cultura), también porque facilita el estudio en profundidad de
redes complejas de relaciones interpersonales (Hamme & Atkinson, 1994).
Dicho esto, las narrativas han sido tenidas en cuenta en distintos ámbitos de las ciencias humanas
donde cada día toman mayor relevancia alimentada por propuestas como las de Hayden White y Paul
Ricoeur, y que en el entendido de las cotidianidades se evidencia a través del lenguaje para la cocreaciones
de sentidos, emociones, reflexiones individuales y colectivas.Política y disca/pacidades Sublínea: Discapacidad y régimen jurídico-legal: salud, educación, trabaj
