1,720,975 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Amélioration de la survie globale des patients porteurs de cancer du rein métastatique grâce aux thérapies ciblées (revue monocentrique depuis 2000)
Full text linkContexte : les thérapies ciblées ont radicalement modifiés la prise en charge thérapeutique des patients atteints de cancer du rein métastatique. Le but de ce travail est de déterminer dans la pratique clinique quotidienne l impact de ces nouvelles thérapies sur la survie globale. Methodes : Etude retrospective, mono-centrique, non interventionnelle incluant les cancers du rein métastatiques à cellules claires diagnostiqués depuis 2000 sur le Centre Hospitalier Universitaire de Grenoble. Les 2 cohortes ont été déterminées en fonction de la première ligne thérapeutique reçue (thérapies ciblées ou autres traitements). Résultats : Quatre-vingt dix-huit patients ont été inclus entre le 1er Janvier 2000 et le 31 Decembre 2010. Les 2 cohortes étaient comparables, en particulier la distribution des profils pronostiques. En premiere ligne, 58 patients ont reçus une thérapie ciblée dont 21% ont été traités par bevacizumab, 71% par sunitinib et 8% par temsirolimus. Dans l autre cohorte (n=40), 37,5% des patients ont reçus des cytokines, 15% une chimiothérapie cytotoxique ou une hormonothérapie. La médiane de survie globale des patients traités par thérapie ciblée est significativement augmentée (30 mois contre 13 mois; p<.003, log-rank test). Le Hazard Ratio (HR) de décès à 3 ans est de 0.53 (intervalle de confiance 95%, 0.33-0.85; p=.008, log-rank test). Le HR de décès à 3 ans ajusté sur le profil pronostique est de 0.43 (IC95%,0.27-0.71). Conclusion : Cette étude retrospective objective l amélioraton de survie globale des patients atteints de cancer du rein métastatique, quelque soit le groupe pronostique, grâce à l apport des thérapies ciblées.Introduction: Anti-angiogenic treatment had radically modified therapeutic strategy in metastatic renal cell carcinoma (mRCC). This study is aimed to determine the overall survival (OS) improvement in clinical practice. Patients and methods: Retrospective, monocentric and non-interventional study in mRCC diagnosed since 2000 with 2 cohorts of patients determined according to the first line treatment (targeted therapy or others treatment). Results: Between 1 January 2000 and 31 December 2010, 98 patients were included. The 2 cohorts were balanced with regard to baseline disease and demographic characteristics in particular for prognosis profiles distribution. As first line, 58 patients received targeted therapy whose 21% were treated by bevacizumab, 71% by sunitinib and 8% by temsirolimus. In non-targeted therapy cohort (n=40), 37.5% were treated by cytokines, 15% by cytotoxic chemotherapy or hormonal therapy. Patients treated with targeted therapy had a significantly longer median OS (30 months vs 13 months; p<.003, log-rank test). The Hazard Ratio (HR) of death at 3 years was 0.53 (95% Confidence Interval, 0.33-0.85; p=.008, log-rank test). When adjusted to the prognosis profile, the HR of death was 0.43 (95%CI, 0.27-0.71). Conclusions: This retrospective study demonstrated the improvement of OS due to targeted treatments, for all prognostic risk groups. This result supported the complete change of care of mRCC patients with extension of therapeutic indications and efficient therapeutic lines.GRENOBLE1-BU Médecine pharm. (385162101) / SudocSudocFranceF
La protéine kinase ck2 (corrélation de la surexpression de la sous-unité catalytique a en immuno-histochimie à des facteurs de mauvais pronostic sur une série de 111 adénocarcinomes de prostate)
No full textLa protéine CK2 est une sérine-thréonine kinase ubiquitaire et conservée au cours de l'évolution. Elle est composée d'un dimère de 2 sous-unités régulatrices b sur lequel s'associent 2 sous-unités catalytiques a. Dans ce travail, l'expression de la CK2a a été étudiée rétrospectivement par immuno-histochimie (IHC) sur cent onze adénocarcinomes de prostate (72 du CU de Grenoble et 39 sur une puce à tissus du commerce). Les patients ont été répartis dans 3 groupes : 0/1+ (expression faible), 2+ (expression modérée) et 3+ et plus (surexpression). La CK2a est plus exprimée dans les glandes prostatiques tumorales que dans les glandes normales et son expression est majoritairement cytoplasmique (p300. Its role in human cancerogenesis remains unclear, but data showed that it promotes proliferation and protect cancer cells against apoptosis. Cristallography depict an heterotetramere, with 2 regulatory subunits (CK2b) associated with 2 catalytic subunits (CK2a). In this study, we performed immunochemistry with a specific anti-CK2a polyclonal antibody. Analysis of 111 samples of human prostate adenocarcinoma showed an overexpression in 43.3% of cases. Patients in this subgroup ( overexpression group ) have bad prognostic factors: 85% with Gleason score up to 6, 48% are pT3-T4 tumors and 63.6% show perineural invasion. By comparison, these percentages are respectively 55.5%, 16% and 38% in the remaining group. Differences are statistically significant (p<0.001 to 0.05). Then, overexpression group seems to be clinically relevant, but survival data are lacking. Furthers investigations are needed to explore the exact role of CK2a in prostate cancer, and to establish if this protein represent a new biomarker.GRENOBLE1-BU Médecine pharm. (385162101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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