16,256 research outputs found
Evaluating user response to in-car haptic feedback touchscreens using the Lane Change Test
No full textTouchscreen interfaces are widely used in modern technology, from mobile devices to in-car infotainment systems. However, touchscreens impose significant visual workload demands on the user which have safety implications for use in cars. Previous studies indicate that the application of haptic feedback can improve both performance of and affective response to user interfaces. This paper reports on and extends the findings of a 2009 study conducted to evaluate the effect of different combinations of touchscreen visual, audible and haptic feedback on driving and task performance, affective response and subjective workload, the initial findings of which were originally published in [8]. A total of 48 non-expert users completed the study. A dual-task approach was applied, using the Lane Change Test as the driving task and realistic automotive use case touchscreen tasks. Results indicated that while feedback type had no effect on driving or task performance, preference was expressed for multimodal feedback over visual alone. Issues with workload and cross-modal interaction were also identified
Dataset supporting the University of Southampton Doctoral Thesis "Endometriosis – It’s Influence on Obstetric and Birth Outcomes and the Potential Role of Reactive Oxygen Species".
No full textDataset supporting the University of Southampton Doctoral Thesis "Endometriosis – It’s influence on obstetric and birth outcomes and the potential role of reactive oxygen species".
The data includes total antioxidant capacity (TAC) assay results, Thiobarbituric acid reactive substances (TBARS) assay results and lumigen total reactive oxygen species (ROS) assay results. These assays were applied to samples of peritoneal fluid, urine and serum of women with and without endometriosis taken at surgery and serum and urine obtained at follow up as part of thesis "Endometriosis – It’s Influence on
Obstetric and Birth Outcomes and the Potential Role of Reactive Oxygen Species"
Results of intracellular redox status experiments. Microinjection of mouse oocytes with roGFP2 mRNA and measured fluorescence (mean integrated density of confocal images) of the oocytes at emission wavelength 530 nm following excitation at 405 nm and 488 nm wavelengths to measure the oxidation/reduction ratio of each oocyte when incubated in peritoneal fluid of women with and without endometriosis and control fluids.
Results of experiments incubating mouse oocytes in peritoneal fluid (of women with and without endometriosis) and control fluids and performing immunofluorescence with Anti-8-OHG antibody. Mean fluorescence of anti-8-OHG was measured by integrated density in pixels.
Data is available only 'on request' to bone fide researchers with ethical approval. Please complete the attached request form and return it to [email protected]
Related projects/Funders:
Funded by the Clinical Obstetric and Gynaecology division of the Human Development and Health department at the University of Southampton
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Una interpretación de a-ka-na-jo ( a3-ka-na-jo)
No full textThe author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word.The author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word
Environmental influences over the last 16 ka on compound-specific δ13C variations of leaf wax n-alkanes in the Hani peat deposit from northeast China
No full textCompound-specific carbon isotope ratios (δ13C) of leaf wax n-alkanes (C21-C33 odd carbon numbered n-alkanes) were measured in the Hani peat sequence from northeast China. These data were compared with lipid biomarker compositions to assess changes in local vegetation and paleoclimate for the last 16 ka The δ13C values of n-alkanes range between -36.6 and -30.7‰, showing that the compounds originate from C3 plants. Much larger variations (∼5.4‰) in the n-alkane δ13C values than those of atmospheric CO2 during the last 16 ka (< 0.5‰) indicate that the isotopic values were affected by environmental factors in addition to the postglacial δ13C variations in the atmospheric reservoir. The stratigraphic records of δ13C reveal decoupled fluctuations among the individual n-alkanes, particularly between 15.5 to 11.4 ka. Synchronous excursions in the δ13C offsets among individual n-alkanes (Δδ13C) and lipid biomarker paleoplant proxies (Paq, and C23/C31 and C27/C31) from 14.9 to 13.2 ka and 12.7 to 11.6 ka suggest that vegetational changes are the most likely causes for the decoupled δ13C variations. Parallel fluctuations of the δ13C values of terrestrial higher plant-derived C29 and C31 n-alkanes and the n-alkane average chain-length (ACL) from 11 to 6 ka indicate that the δ13C variations responded to net evaporation changes. Negative shifts in the n-alkane δ13C values coinciding with the ACL decreases at 10.5-9.3 ka and 8.1 ka indicate the short-term onset and fluctuations of the summer monsoon strength in eastern China during the early Holocene
NRF2 and chemoprevention: signaling, epigenetics and role in intestinal carcinogensis
No full textPrevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage. Chemoprevention becomes an increasing important concept and has led to the intense research about the mechanisms of actions of various chemopreventive compounds. They can be generally classified into blocking agents and suppressing agents. The chemopreventive compounds usually prevent or slow progression of cancer by maintaining a low oxidative stress and inflammatory environment in cells. This is brought about by the activation of Nrf2, the key protein being investigated in our lab. In this dissertation, I will be discussing the use of compounds as suppressing agents and blocking agents, how compounds activates Nrf2 signaling, how novel Nrf2 interaction partner IQGAP1 mediates Nrf2-Keap1 signaling axis, how expression level of Nrf2 could be regulated epigenetically, apart from the well-known post-translational control by Keap1-Ubiquitinase-Protesome axis and finally how loss of Nrf2 could enhance intestinal tumorigenesis in Apc(min/+) mice.Ph.D.Includes bibliographical referencesIncludes vitaby Ka Lung Cheun
Nearby fibroblasts' response to multiple acupuncture needle revolutions on fibroblast populated collagen gels
No full textAcupuncture is an ancient Chinese healing practice, and an alternative therapy for alleviating pain and chronic disorders. For over twenty years, research is trying to understand the mechanisms that lead to its therapeutic effect. Our laboratory investigates the cellular and molecular events in the connective tissue that occur by acupuncture needling. An in vitro assay was developed to evaluate some of the potential contributors to acupuncture’s effects using a cellular collagen gel as a loose connective tissue mimic. It was hypothesized besides immediate changes to cells under mechanical loading from an acupuncture needle, there were chemical factors released to nearby cells in acupuncture. This thesis investigates whether mechanically stimulating collagen gels with fibroblasts at different revolutions would release chemical factors to nearby fibroblasts where flow cytometry was used to observe cell proliferation as an indicator. Results reveal mechanically stimulating cellular collagen gels at different revolutions does not cause any changes in cell proliferation to nearby cells. However, dead stained mechanically stimulated cellular collagen gels showed cell death occurs around the acupuncture needle. It is possible there were no effects in cell proliferation because when a cellular collagen gel was needle manipulated, some chemical factors were released into the nearby cells. Then as needle manipulation increased, more chemical factors were released, but restricted by the larger amount of cell death around the needle from the increasing rotation.M.S.Includes bibliographical referencesby Ka Po Ch
Duan wei xia mu xie lei de xin xing he nei DNA fen zi xi tong biao ji zhi jian ding
No full textLeung Ka Chun.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 100-110).Abstracts also in Chinese.Title from PDF title page (viewed on 21, September, 2016).Leung Ka Chun
San zhong chao jian dai teng hu dui gao wen de sheng li fan ying ji zhuan lu ti yan jiu
No full textWong, Ka Wing Karen.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 143-157).Abstracts also in Chinese.Title from PDF title page (viewed on 30, November, 2016).Wong, Ka Wing Karen
Glass compositions and tempo of post-17 ka eruptions from the Afar Triangle recorded in sediments from lakes Ashenge and Hayk, Ethiopia
No full textNumerous volcanoes in the Afar Triangle and adjacent Ethiopian Rift Valley have erupted during the Quaternary, depositing volcanic ash (tephra) horizons that have provided crucial chronology for archaeological sites in eastern Africa. However, late Pleistocene and Holocene tephras have hitherto been largely unstudied and the more recent volcanic history of Ethiopia remains poorly constrained. Here, we use sediments from lakes Ashenge and Hayk (Ethiopian Highlands) to construct the first <17 cal ka BP tephrostratigraphy for the Afar Triangle. The tephra record reveals 21 visible and crypto-tephra layers, and our new database of major and trace element glass compositions will aid the future identification of these tephra layers from proximal to distal locations. Tephra compositions include comendites, pantellerites and minor peraluminous and metaluminous rhyolites. Variable and distinct glass compositions of the tephra layers indicate they may have been erupted from as many as seven volcanoes, most likely located in the Afar Triangle. Between 15.3−1.6 cal. ka BP, explosive eruptions occurred at a return period of <1000 years. The majority of tephras are dated at 7.5−1.6 cal. ka BP, possibly reflecting a peak in regional volcanic activity. These findings demonstrate the potential and necessity for further study to construct a comprehensive tephra framework. Such tephrostratigraphic work will support the understanding of volcanic hazards in this rapidly developing region
Cryptotephra from a ~120 ka Tondano eruption in a sediment core from Lake Towuti (Indonesia)
No full textSoutheast Asia is one of the most volcanically active regions in the world, yet their long-term eruptive history has been comparatively little studied. In particular, little work has explored the potential of sedimentary archives to record distal cryptotephra, which may help in identifying some of the region's larger Quaternary eruptions. Here, we report the finding of cryptotephra in a sediment core from Lake Towuti (Sulawesi, Indonesia). Based on glass geochemistry and core stratigraphy, we attribute the deposit to a ~120?ka eruption of Tondano, a large caldera situated on the Minahasa peninsula of Sulawesi. The minimal (~38 shards per gram) amount of tephra deposition hints at the limited ecological impact and/or magnitude of the eruption as well as establishing a new isochron that may enable synchronisation of late-Pleistocene sedimentary archives
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