1,793 research outputs found
Quality of life and climacteric complaints amongst women seeking medical advice in Taiwan: assessment using the WHOQOL-BREF questionnaire
No full textDevelopment of active safety surveillance system for traditional Chinese medicine: An empirical study in treating climacteric women
No full text
Fisheries in Yonki Reservoir, Papua New Guinea
No full textA year after Yonkl Reservoir (Eastern Highlands Province, Papua New Guinea) had been completed, a su1wy was conducted among people found fishing at the shore. Rod and line was used in 99% of the reported fishing trips. On an average 0.42 kg of fish was caught per person per trip. The average catch per hookhour was 0. 033 kg of the past fishing trips, and 0. 021 kg of the on-going fishing trips. The first half of the year during which interviews were conducted the catch was composed only of Cyprinus carpio and Oreochromis mossambicus. In mid-1992 Tilapia rendalli appeared in the catch, and six months later this species was responsible for 48% of the weight of the dally catch. The total catch from the reservoir for the year 1992 was estimated al 40.2 tons
The dynamics of single spike-evoked adenosine release in the cerebellum
Full text linkThe purine adenosine is a potent neuromodulator in the brain, with roles in a number
of diverse physiological and pathological processes. Modulators such as adenosine are difficult
to study as once released they have a diffuse action (which can affect many neurones) and,
unlike classical neurotransmitters, have no inotropic receptors. Thus rapid postsynaptic currents
(PSCs) mediated by adenosine (equivalent to mPSCs) are not available for study. As a result
the mechanisms and properties of adenosine release still remain relatively unclear. We have
studied adenosine release evoked by stimulating the parallel fibres in the cerebellum. Using
adenosine biosensors combined with deconvolution analysis and mathematical modelling, we
have characterised the release dynamics and diffusion of adenosine in unprecedented detail.
By partially blocking K+ channels, we were able to release adenosine in response to a single
stimulus rather than a train of stimuli. This allowed reliable sub-second release of reproducible
quantities of adenosine with stereotypic concentration waveforms that agreed well with predictions
of a mathematical model of purine diffusion. We found no evidence for ATP release
and thus suggest that adenosine is directly released in response to parallel fibre firing and does
not arise from extracellular ATP metabolism. Adenosine release events showed novel short-term
dynamics, including facilitated release with paired stimuli at millisecond stimulation intervals
but depletion-recovery dynamics with paired stimuli delivered over minute time scales. These
results demonstrate rich dynamics for adenosine release that are placed, for the first time, on a
quantitative footing and show strong similarity with vesicular exocytosis
Erratum: A Survey of Paediatric Eye Diseases in a Tertiary Hospital, Southwest Nigeria
Full text linkIn the article titled “A Survey of Pediatric Eye Diseases in a Tertiary Hospital, South Western Nigeria”, published on pages 149-54, Issue 2, Volume 30 of Nigerian Journal of Medicine [1], the name of the second author is written incorrectly as “Ubah Josephine Ngozi” instead of “Ubah Josephine Nonye”.The “How to cite this article” section should read correctly as “Isawumi MA, Ubah JN. A survey of paediatric eye diseases in a tertiary hospital, Southwest Nigeria. Niger J Med 2021;30:149-54”
Time-Domain Simulation of Mixed Nonlinear Magnetic and Electronic Systems
No full textThis paper describes a technique for the simulation of complex magnetic systems intimately connected to any necessary drive electronics. The system is split into two Kirchhoffian domains, one magnetic and one electric. Two-way interaction between the domains is supported by a virtual device called a magneto-electric differential gyrator. Using this technique, arbitrarily complex, non-linear, hysteretic magnetic systems may be simulated in the time domain, coupled to any appropriate non-linear electronics, at a fraction of the cost of a comparable finite element calculation. The capabilities of the system are demonstrated by the simulation of a feedback-controlled current sensing system, and the simulation tracks the measured behaviour of the system well outside its linear region, to the point that the non-linear hysteretic core is being driven into and out of saturation, a consequence of a time delay inherent in the electronics. This is compared with a simulation of the same system using a 'conventional' electronic simulation, and the increased accuracy of this technique clearly demonstrated
An assessment of the bioaccumulation of estrone in Daphnia magna
No full textThe bioaccumulation of estrone by Daphnia magna was determined. Direct uptake via the aqueous medium occurred within the first 16 hours. A bioconcentration factor of 228 was established over all temporal periods. Ingestion via Chlorella vulgaris gave a partitioning factor of 24 which may approximate to a biomagnification factor assuming steady state conditions. These preliminary results indicate that the partitioning to Daphnia magna via the food source, Chorella vulgaris is less significant than bioconcentration
The Word was the true light (Jn 1:9a). Jesus as the Light in the Prologue of the Fourth Gospel
Full text linkThis article aims to „The true light (Jn 1.9a). Jesus as the light in the Prologue of the Fourth
Gospel”, was to explain the meaning of the symbol of the light connected with the person of Jesus
Christ - the Logos in the Prologue of the Gospel of St John. The analysis of the text helped to
establish that the author wanted to show the person o f Logos as a necessary condition of all life,
and above all, the supernatural life (Jn 1,4). By revealing the divine life through the Incarnation,
whose symbol is a light, he met with extreme hostility, which, however, is unable to destroy him
(Jn 1,5). He is the light in an absolute sense (Jn 1,9). No one besides Him can not bestow the light,
which in its fullest sense is identified with salvation. Father (John 5,31-32.37-38; 8,16-19), the Holy
Spirit (Jn 15,26), the work of Jesus (Jn 5,36,10,25) and John the Baptist (Jn 1,7-8; 19nn) bear
witness of His light, that people believed in him and thus have eternal life (Jn 20,31)
Development of adenosine signalling in the cerebellum
Full text linkThe release and clearance of adenosine are reasonably well-documented in the
mature CNS but relatively little is known about how adenosine signalling changes
during postnatal development. The activation of presynaptic A1 receptors (A1R) at
cerebellar parallel fibre terminals is known to inhibit synaptic transmission and the
expression of A1R has been observed in mature rat cerebellar slices. However its
distribution during development or in relation to parallel fibre–Purkinje cell (PF-PC)
synapses has not previously been described. In the mature cerebellum blockade of
presynaptic A1R at PF-PC synapses enhances synaptic transmission suggesting an
inhibitory adenosine tone and an extracellular purine tone is detectable with
microelectrode biosensors under basal conditions. The active release of adenosine
can be stimulated with trains of activity in the molecular layer of mature slices
although this does not appear to be a source of the basal extracellular adenosine tone.
This study used immunohistochemistry to determine the distribution of A1R at PFPC
synapses in cerebellar slices at postnatal day 3 prior to PF-PC synapse formation,
postnatal days 8-14 and postnatal days 21-28. This study also used cerebellar slices
from rats at postnatal days 9-14 to investigate the pharmacological profile of the
immature rat PF-PC synapse with electrophysiology and microelectrode biosensors.
The immunohistochemistry suggests that A1R are widely distributed across Purkinje
cell bodies and their dendrites and within the granule layer of the cerebellum and that
its expression does not change during development. The same staining patterns were
also observed prior to PF-PC synapse formation.
Application of adenosine resulted in a variable A1R-mediated inhibition at immature
PF-PC synapses. This did not appear to be gender-specific or correlated with age of
rat and the synapses otherwise appeared identical in their properties. The
comparison of log concentration-response curves generated for an A1R agonist
suggested that some A1R may have a lower efficacy at this stage of development.
Blockade of presynaptic A1R at immature PF-PC synapses suggested that an
inhibitory adenosine tone is low or absent at this stage of development and is not the
result of a low A1R expression or developmental differences in A1R efficacy.
Inhibition of adenosine clearance via adenosine deaminase, adenosine kinase and
equilibrative transporters had little effect on synaptic transmission suggesting that
little adenosine is moving between the intracellular and extracellular spaces under
basal conditions in immature slices. Active adenosine release measured by
electrophysiology and microelectrode biosensors could be stimulated with hypoxia in
immature slices but this was delayed and slower in comparison to the release
observed in mature slices. Adenosine could not be actively released at immature PFPC
synapses in response to electrical stimulation in the molecular layer
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