386 research outputs found
Stephane Mallarme: A synthesis of romanticism and parnassianism, 1970
No full textThe purpose of this paper is to analyse works of Stephane Mallarme, father of Symbolism, pointing out romantic and parnassian elements. Symbolism, like Romanticism, attempted to express the interior thoughts of man. The symbolist movement then, was not only a revolt against Parnassianism but also a return to Romanticism. On the other hand, one would not be incorrect in saying that Romanticism reached its culmination in the works of the symbolists poets. For this reason, an attempt will be made to show that the works of Mallarme, father of Symbolism, can be considered as a synthesis of Romanticism and Parnassianism. This thesis contains three chapters. The first chapter is devoted to a discussion of Romanticism and of Parnassianism. Special attention is given to the origin, development, characteristics and influences of each school. The relationship of one School with the other is also pointed out. The second chapter consists of a biographical sketch of Stephane Mallarme. Special emphasis is placed on factors and events in his life which may have influenced or determined the elements of Romanticism and Parnassianism in his poetry. The third chapter is devoted to an analysis of some of the poems of Stephane Mallarme", "Les Fenetres," V Apparition," "L'Azur," "Toast Funebre," "Le Vierge," "L'Apres-Midi d'un Faune." In these analyses special attention is given to the romantic and parnassian tendencies of the poems. Since these romantic-parnaassian elements occur frequently throughout his works, it has been concluded that Mallarme's poetry can be considered as a synthesis of the two poetic schools
Echocardiographic parameters of ventricular dyssynchrony validation in patients with heart failure using sequential biventricular pacing
No full text© 2004 American College of Cardiology Foundation Published by Elsevier Inc.ObjectivesWe sought to evaluate the relationship between hemodynamic and ventricular dyssynchrony parameters in patients undergoing simultaneous and sequential biventricular pacing (BVP).BackgroundVarious echocardiographic parameters of ventricular dyssynchrony have been proposed to screen and optimize BVP therapy.MethodsForty-one patients with heart failure undergoing BVP implantation were studied. Echocardiography coupled with tissue tracking and pulsed Doppler tissue imaging (DTI) was performed before and after BVP implantation and after three months of optimized BVP. Indexes of inter- or intraventricular dyssynchrony were correlated with hemodynamic changes during simultaneous and sequential BVP (10 intervals of right ventricular [RV] or left ventricular [LV] pre-excitation).ResultsVariations in intra-LV delay(peak), intra-LV delay(onset), and index of LV dyssynchrony measured by pulsed DTI were highly correlated with those of cardiac output (r = -0.67, r = -0.64, and r = -0.67, respectively; p ConclusionsSpecific echocardiographic measurements of ventricular dyssynchrony are highly correlated with hemodynamic changes and may be a useful adjunct in the selection and optimization of BVP. Individually optimized sequential BVP provided a significant early hemodynamic improvement compared with simultaneous BVP.Pierre Bordachar, Stephane Lafitte, Sylvain Reuter, Prashanthan Sanders, Pierre Jaïs, Michel Haïssaguerre, Raymond Roudaut, Stephane Garrigue and Jacques Clement
Biventricular pacing and left ventricular pacing in heart failure: similar hemodynamic improvement despite marked electromechanical differences
No full textThe definitive version is available at www.blackwell-synergy.comIntroduction: We conducted an acute echocardiographic study comparing hemodynamic and ventricular dyssynchrony parameters during left ventricular pacing (LVP) and biventricular pacing (BVP). We sought to clarify the mechanisms responsible for similar hemodynamic improvement despite differences in electrical activation. Methods and Results: Thirty-three patients underwent echocardiography prior to implantation with a multisite pacing device (spontaneous rhythm [SR]) and 2 days after implantation (BVP and LVP). Interventricular dyssynchrony (pulsed-wave Doppler), extent of myocardium displaying delayed longitudinal contraction (%DLC; tissue tracking), and index of LV dyssynchrony (pulsed-wave tissue Doppler imaging) were assessed. Compared to SR, BVP and LVP caused similar significant improvement of cardiac output (LVP: 3.2 ± 0.5, BVP: 3.1 ± 0.7, SR: 2.3 ± 0.6 L/min; P < 0.01) and mitral regurgitation (LVP: 25.1 ± 10, BVP: 24.7 ± 11, baseline: 37.9 ± 14% jet area/left atria area; P < 0.01). LVP resulted in a smaller index of LV dyssynchrony than BVP (29 ± 10 vs 34 ± 14; P < 0.05). However, LVP exhibited a longer aortic preejection delay (220 ± 34 vs 186 ± 28 msec; P < 0.01), longer LV electromechanical delays (244.5 ± 39 vs 209.5 ± 47 msec; P < 0.05), greater interventricular dyssynchrony (56.6 ± 18 vs 31.4 ± 18; P < 0.01), and higher%DLC (40.1 ± 08 vs 30.3 ± 09; P < 0.05), leading to shorter LV filling time (387 ± 54 vs 348 ± 44 msec; P < 0.05) compared to BVP. Conclusion: Although LVP and BVP provide similar hemodynamic improvement, LVP results in more homogeneous but substantially delayed LV contraction, leading to shortened filling time and less reduction in postsystolic contraction. These data may influence the choice of individual optimal pacing configuration.Pierre Bordachar, Stephane Lafitte, Sylvain Reuter, Stephane Garrigue, Prashanthan Sanders, Raymond Roudaut, Pierre Jaïs, Michel Haïssaguerre, Jacques Clement
Obama's visit to Korea : an unwavering US-ROC alliance amidst regional tensions
No full textFor more about the East-West Center, see http://www.eastwestcenter.org/Stephane Mot, Independent Author and Blogger living in Seoul, explains that "Obama's visit did not change the opinion of the vast majority of South Koreans who consider the US-ROK alliance to be unequal, but it did further confirm the importance of South Korea for US engagement towards Asia.
Long-term outcomes of concomitant suture bicuspidization technique to treat mild or moderate tricuspid regurgitation in patients undergoing mitral valve surgery
No full textObjectives: The aim of this study was to investigate the long-term outcomes of concomitant suture bicuspidization to treat mild or moderate tricuspid regurgitation at the time of mitral valve (MV) surgery. Methods: Data from patients who underwent MV surgery for degenerative MV regurgitation with mild or moderate tricuspid regurgitation and annular dilatation between January 2009 and December 2017 were analysed. The cohort was divided into 2 groups: mitral valve surgery alone (MVA) and MV surgery with concomitant tricuspid valve (TV) repair. Results: A total of 196 patients were included in the study. MVA and MV surgery with concomitant TV repair were performed in 91 (46.4%) and 105 (53.6%) patients, respectively. Propensity score matching analysis identified 54 pairs. In the matched cohort, 30-day mortality (0.0% vs 1.9%, P = 1.0) and new permanent pacemaker implantation (11.1% vs 7.4%, P = 0.740) did not differ significantly between groups. After a mean follow-up of 6.0 (2.8) years, MV surgery with concomitant TV repair was not associated with increased mortality risk compared to MVA (hazard ratio 1.04, 95% confidence interval 0.47-2.28, P = 0.927) with 10-year overall survival rates of 69.9% and 77.2%, respectively. Furthermore, MV surgery with concomitant TV repair was associated with a significantly reduced progression of TV regurgitation (P < 0.001). Conclusions: Patients undergoing MV surgery with concomitant TV repair had similar 30-day and long-term survival, similar permanent pacemaker implantation rate and reduced progression of TV regurgitation compared to those undergoing MVA
Detrimental ventricular remodeling in patients with congenital complete heart block and chronic right ventricular apical pacing
No full text© 2004 American Heart Association, Inc.BackgroundAlthough dual-chamber pacing improves cardiac function in patients with complete congenital atrioventricular block (CCAVB) by restoring physiological heart rate and atrioventricular synchronization, the long-term detrimental effect of asynchronous electromechanical activation induced by apical right ventricular pacing (RVP) has not been well clarified.Methods and resultsTwenty-three CCAVB adults (24+/-3 years) with a DDD transvenous pacemaker underwent conventional echocardiography before implantation and, after at least 5 years of RVP, an exercise test and echocardiography coupled with tissue Doppler imaging and tissue tracking. They were compared with 30 matched healthy control subjects. After 10+/-3 years of RVP, CCAVB adults had significantly higher values versus controls in terms of intra-left ventricular (LV) asynchrony (respectively, 59+/-18 versus 19+/-9 ms, PConclusionsProlonged ventricular dyssynchrony induced by long-term endovenous RVP is associated with deleterious LV remodeling, LV dilatation, LV asymmetrical hypertrophy, and low exercise capacity. These new data highlight the importance of the ventricular activation sequence in all patients with chronic ventricular pacing.Jean-Benoît Thambo; Pierre Bordachar; Stephane Garrigue; Stephane Lafitte; Prashanthan Sanders; Sylvain Reuter; Romain Girardot; David Crepin; Patricia Reant; Raymond Roudaut; Pierre Jaïs; Michel Haïssaguerre; Jacques Clementy; Maria Jimene
Do We Need New Echocardiographic Prognosticators for the Management of Heart Failure Patients?⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
No full textThe Quest for Citations: Drivers of Article Impact
No full textWhy do some articles become building blocks for future scholars, while many others remain unnoticed? We aim to answer this question by contrasting, synthesizing and simultaneously testing three scientometric perspectives – universalism, social constructivism and presentation – on the influence of article and author characteristics on article citations. To do so, we study all articles published in a sample of five major journals in marketing from 1990 to 2002 that are central to the discipline. We count the number of citations each of these articles has received and regress this count on an extensive set of characteristics of the article (i.e. article quality, article domain, title length, the use of attention grabbers and expositional clarity), and the author (i.e. author visibility and author personal promotion). We find that the number of citations an article in the marketing discipline receives, depends upon “what one says†(quality and domain), on “who says it†(author visibility and personal promotion) and not so much on “how one says it†(title length, the use of attention grabbers, and expositional clarity). Our insights contribute to the marketing literature and are relevant to scientific stakeholders, such as the management of scientific journals and individual academic scholars, as they strive to maximize citations. They are also relevant to marketing practitioners. They inform practitioners on characteristics of the academic journals in marketing and their relevance to decisions they face. On the other hand, they also raise challenges towards making our journals accessible and relevant to marketing practitioners: (1) authors visible to academics are not necessarily visible to practitioners; (2) the readability of an article may hurt academic credibility and impact, while it may be instrumental in influencing practitioners; (3) it remains questionable whether articles that academics assess to be of high quality are also managerially relevant.Impact;Citation Analysis;Referencing;Scientometrics;Cite
Modeling Process of a Third Dimension Universe for Transportation Simulation: Application to Railway System
No full textIn past years, 3D models of virtual worlds have been used in several applications such as urban planning, simulation and design. In the railway field, that we chose as a field of application to illustrate our proposals in this article, simulation makes sense because of the complexity involved and the risk for personnel during upstream phases of validation. To be able to simulation with enough precision, the model of the virtual universe is a key point. Especially For train component simulation, an accurate and detailed model of the train component is mandatory. For training the drivers within a serious game, a high visual quality is required. Obtaining a single model supporting these two constraints at the same time at the lowest cost is still an open issue and involved many actors. Our contribution is a methodology and a process for creating a virtual universe model, based on automatic model generation, in order to allow the creation of large-scale universes while guaranteeing a level of details appropriate to the need, a model of constant quality and including semantic data necessary for simulation, while reducing the modeling costs and the modeling duration. The proposed process is applied to train simulation.Part of this work carried out under the ASTRES project supported by the Alstom Transport Company. The views and conclusions contained within this document are those of the authors, and should not be interpreted as representing the official policies, either expressed or implied, of the Alstom Transport Company.Galland, S (reprint author), Univ Bourgogne Franche Comte, UTBM, LE2I, Multiagent Grp, F-90010 Belfort, France.
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The discovery of SycO reveals a new function for type three secretion effector chaperones
No full textThe Type Three Secretion (T3S) system is a device used by many Gram-negative pathogens that allows bacteria to deliver effector proteins straight into the eukaryotic cell cytosol. These effectors interfere with various signaling pathways to subvert the host cell functions. The secretion machinery of the T3S system consist of a basal body spanning the bacterial inner and outer membrane followed by a stiff hollow needle outside the bacterium. The fully assembled secretion apparatus constitute a continuous hollow conduit that connects the bacteria to the eukaryotic target cell. After cell contact, virulence proteins -called effectors- are injected directly into the cytosol of the host cell via the T3S apparatus. Several effectors of the T3S system require the assistance of specific cytosolic chaperones to be efficiently exported. There are three classes of T3S chaperones. Effector proteins are assisted by Class I chaperones. Although Class I chaperones are well characterized, their main function is still a matter of controversy. In this thesis, we demonstrate that orf155 encodes a specific chaperone for the effector YopO that we called SycO. We showed that SycO enhances YopO secretion in vitro and is required for translocation of YopO into infected cells. By pulldown assay we demonstrated that residues 20 to 77 of YopO are required and sufficient for SycO binding. Using crosslinking experiments and size exclusion chromatography analysis, we determined the stoichiometry of purified SycO and YopO-SycO complexes. SycO alone forms dimers in solution and the YopO-SycO complex has a 1:2 stoichiometry. These results suggested that SycO is a typical chaperone of the Class I. YopO is a serine/theronine kinase that interacts with Rho and Rac and disrupts the cytoskeleton of the target cells. YopO has been shown to localize at the cell plasma-membrane. By transfection of YopO-EGFP hybrid proteins into HEK293T cells, we demonstrated that the chaperone-binding domain (CBD) coincides with the membrane localization domain of YopO. Nevertheless, the CBD was not needed for the kinase activity of YopO. By ultracentrifugation, we also showed that the CBD causes YopO aggregation in the bacteria, when SycO does not cover it. Further, we show that the CBD of YopE and YopT also caused aggregation in the bacteria in the absence of SycE and SycT respectively. YopE, YopT and T3S effectors in other systems also act at the membrane of the eukaryotic host cell. We propose a new hypothesis concerning the role of T3S chaperones. The sub-cellular localization domain of effectors is aggregation-prone and creates the need for a chaperone inside bacteria. We propose that masking such aggregation-prone localization domains may be a general function for type III effector chaperones
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