1,720,962 research outputs found
Can gold nanoparticles improve delivery performance of polymeric drug delivery systems?
Full text linkDuring the recent developments in nanomedicine, gold nanoparticles (Au NPs) have emerged as interesting tools
in the field of drug-delivery systems (DDS) due to their low toxicity, stability, easy synthesis and reproducibility [1].
Au NPs are able to link therapeutic molecules on their surface by covalent or noncovalent bonding or by a previous
functionalization of Au NPs and release the drug only in a specific site without damaging the healthy tissue [2].
Moreover, the small size of gold NPs allows their accumulation in sites of tumor and inflammation and exhibit
fast cell uptake using mechanisms different from those typical of small molecules [3]. Their optical property is
characterized by surface plasmon resonance (SPR), by which incident light is converted into heat, which makes
them very useful in promoting photothermal drug release [4]. The main drawback resides in the fact that after their
administration, if not confined, they escape through the circulatory torrent without reaching the target site and so
losing their efficacy. For this purpose, hybrid materials formed by the loading of Au NPs inside polymer networks
are studied to improve local drug delivery. In this case, the easy injection and confinement of the hydrogel in the
site of injury represent the main advantages together with local release of both small and large molecules in response
to thermal stimuli [5]
Thermo-responsive polymer-based nanoparticles: from chemical design to advanced applications
Full text linkThermo-responsive polymers have emerged as a cutting-edge tool in nanomedicine, paving the way for innovative approaches to targeted drug delivery and advanced therapeutic strategies. These “smart” polymers respond to temperature changes, enabling controlled drug release in pathological environments characterized by high temperatures. By exploiting their unique phase transition, occurring at the lower or upper critical solution temperatures (LCST and UCST), these systems ensure localized therapeutic action, minimizing collateral damage to healthy tissues. The integration of these polymers into nanoparticles with hydrophilic shells and hydrophobic cores enhances their stability and biocompatibility. Furthermore, advanced polymer engineering allows precise modulation of LCST and UCST through adjustments in composition and hydrophilic-lipophilic balance, optimizing their responsiveness for specific applications. In addition to drug delivery, thermo-responsive nanoparticles are gaining attention in several fields such as gene therapy and imaging. Therefore, this review explores the chemical and structural diversity of thermo-responsive nanoparticles, emphasizing their ability to encapsulate and release drugs effectively. Second, this review highlights the potential of thermo-responsive nanoparticles to redefine treatment paradigms, providing a comprehensive understanding of their mechanisms, applications, and future perspectives in biomedical research
On the role of polymeric hydrogels in the thermal response of gold nanorods under NIR laser irradiation
Full text linkHydrogels are 3D cross-linked networks of polymeric chains designed to be used in the human body. Nowadays they find widespread applications in the biomedical field and are particularly attractive as drug delivery vectors. However, despite many good results, their release performance is sometimes very quick and uncontrolled, being forced by the high in vivo clearance of body fluids. In this direction, the development of novel responsive nanomaterials promises to overcome the drawbacks of common hydrogels, inducing responsive properties in three-dimensional polymeric devices. In this study, we synthesized and then loaded gold nanorods (Au NRs) within an agarose-carbomer (AC)-based hydrogel obtained from a microwave-assisted polycondensation reaction between carbomer 974P and agarose. The photothermal effect of the composite device was quantified in terms of maximum temperature and spatial-temporal temperature distribution, also during consecutive laser irradiations. This work shows that composite Au NRs loaded within AC hydrogels can serve as a stable photothermal treatment agent with enhanced photothermal efficiency and good thermal stability after consecutive laser irradiations. These results confirm that the composite system produced can exhibit an enhanced thermal effect under NIR laser irradiation, which is expected to lead to great therapeutic advantages for the localized treatment of different diseases.
Hydrogels are 3D cross-linked networks of polymeric chains designed to be used in the human body
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Magnetically active bicontinuous polymer structures for multiple controlled drug delivery
Full text linkThe targeted delivery of drugs using wireless navigable magnetic robots allows the delivery of drug molecules to be controlled non only in time but also in space, improving medical outcomes. The main disadvantages behind their use lies in the low amount of drug that can be transported and the single nature of drug that can be loaded (hydrophilic or hydrophobic). These considerations limit their use in co-delivery systems, now recognized to be very promising for many different pathologies. A magnetic bijel-like structure is developed to load and release different types of molecules (hydrophilic and hydrophobic). In this work, the use of ε-caprolactone is explored, which can polymerize, forming hydrophobic domains (oil phase). After mixing with iron oxide nanoparticles (NPs), the water dispersion creates a magnetic biphasic porous structure without phase separation. The resulting device shows good performance both in magnetic actuation and as a drug delivery system
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