1,720,975 research outputs found

    Clinical features and long-term outcome of ipsilateral delayed endolymphatic hydrops

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    BACKGROUND: Ipsilateral delayed endolymphatic hydrops (IDEH) is a disease characterized by recurrent acute vertigo that manifests after the appearance of a severe sensorineural non-hydropic hearing loss without symptomatology at the other ear. The cause of hearing loss can be congenital or acquired and, in the latter group, the hearing loss is usually sudden or secondary to head or acoustic trauma, ear surgery, viral infection, otitis media, streptomycin, meningitis, inner ear abnormality or idiopathic. METHODS: Data from 37 IDEH patients, who account for 3.4% of the overall sample of menieric patients at our institution, were analyzed in this retrospective study. RESULTLTS: The mean age of the sample was 58 years. Mean duration of the disease at the moment of diagnosis was 57 months. Follow-up ranged from 24 to 180 months (average: 87 months). Hearing loss at the ear cause of IDEH was due to sudden hearing loss in 23 cases (62%), chronic otitis operated on in five cases (14%) and congenital in one case (3%); in eight cases (21%) the cause of hearing loss was unknown. Mean age of appearance of IDEH was 54 years, mean interval between the appearance of HL and IDEH was 82 months and mean duration of the disease at the time of diagnosis was 57 months. Mean PTATA threshold at the affected ear was 88 dB. After dietetic and medical treatment, with a follow-up of 24 to 180 months (average: 87 months), we have obtained the resolution of vertigo crisis, or an acceptable reduction in crisis intensity and/or frequency, in 50 patients (88%). In the remaining seven patients intratympanic gentamicin, following the titration method, was applied, with the resolution of vertigo in six of them (88%); in one cases we have carried out the labyrinthectomy, that solved vertigo crisis. CONCLUSIONS: In conclusion IDEH is a not frequent form of Ménière's disease with good long-term prognosis and in case on vertigo not responsive to medical therapy intratympanic gentamicin labyrinthectomy can solve symptomatology

    Condition of the anterior part of the middle ear cleft in acquired cholesteatoma

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    CONCLUSION: The high rate of flogistic suffering of the controlateral ear seems to suggest a correlation between tubal dysfunction and acquired cholesteatoma but the low rate of pathological reports regarding the anterior mesotympanic region exclude a eustachian tube dysfunction (EDT) at the time of surgery. These observations support the hypothesis that ETD is not a factor that may influence the evolution of the cholesteatoma. OBJECTIVES: To evaluate the role of eustachian tube function in the middle ear secondary acquired cholesteatoma. PATIENTS AND METHODS: This was a case series study. The study group consisted of 72 patients submitted to tympanoplasty for middle ear secondary acquired cholesteatoma. RESULTS: The contralateral ear was normal in 37 subjects (51%) and affected by chronic otitis media in 35 (49%); the anterior part of middle ear cleft was normal in 53 patients (74%). There was no significant relationship between the contralateral ear condition and the status of the anterior region of middle ear (p>0.05). The site of retraction or the presence of tympanic perforation with skin migration was not related to the condition of the protympanum. Otorrhea, cholesteatoma extension, and ossicular chain lesions were not significantly related to the status of the anterior part of the middle ear cleft (p>0.05)

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Cyclosporine a as a possible cause of upbeating nystagmus

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    Cyclosporine A (CsA) has assumed a central role in the pro-phylaxis of acute graft-versus-host disease after allogenic bone marrow transplantation; however, its potential neurotoxicity can manifest in 10-35% of patients. In most cases, neurotoxicity is transient, but fatal cases have been described. We report a case of acute upbeating nystagmus appearing subsequent to the hematic peak of CsA in a patient undergoing prophylactic treatment for acute graft-versus-host disease after bone marrow transplantation for chronic myeloid leukemia. Computed tomography and magnetic resonance imaging revealed no abnormalities. Although reduced, the upbeating nystagmus persisted over time. To our knowledge, this is the first case in which upbeating nystagmus manifests as a possible consequence of CsA therapy

    Underlay or overlay myringoplasty in children: Which approach is better?

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    BACKGROUND: Bilateral tympanic membrane perforation may cause a loss of hearing resulting in impaired social interactions and academic performance, delayed language and cognitive development, and lower learning abilities in children, the overlay and the underlay techniques are the two standard methods for perforation repair, with much debate between which of the two is better, especially from the functional point of view. We compared the perforation closure rates and hearing improvement after surgery with the overlay and the underlay techniques to determine which of the two is preferable for tympanic membrane perforation repair in children. METHODS: This retrospective study involved 149 patients who had undergone myringoplasty. Pure tone audiometry was conducted before and after surgery and functional results were defined considering the air bone gap. RESULTS: The overall perforation closure rate was 91.9% in underlay and 90% in overlay technique and the air-bone gap <10 dB was respectively 60.6% and 38%. CONCLUSIONS: In conclusion, myringoplasty may be safe even in younger children and both techniques can achieve high rates of anatomical success. The optimal results after the underlay technique suggest that it should be more widely used and that it should be the first option when considering repair of tympanic membrane perforation

    A new bone conduction hearing aid to predict hearing outcome with an active implanted device

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    Purpose: We compared our historical medium-term data obtained with an active semi-implanted bone conduction device and the hearing results of a new passive bone conduction hearing device to determine its predictive value for the hearing results with the semi-implanted device. Methods: The study sample was 15 patients with an active bone conduction implant (mean follow-up 26 months). Pure tone audiometry was performed with headphones, sound field speech audiometry was conducted unaided, and free-field speech audiometry was carried out with both the active bone conduction system and the passive device switched off. Results: As compared with the unaided condition, speech reception was significantly improved with both devices. Comparison of speech reception threshold at 100% of word recognition showed no difference between the active and the passive device. At lower intensity the difference in speech perception was significant in the patients with monaural fitting (group A) and was non-statistically significant in those with binaural fitting (group B); the speech reception threshold at 50% of word recognition was 26.00 dB (± 10.22) with the active implant and 30.50 dB (± 7.98) with the passive device in group A (p = 0.047) and 24.00 dB (± 5.48) and 29.00 dB (± 2.24) in group B (p = 0.052), respectively. Conclusions: The hearing outcome after active bone conduction implant was comparable to published data. Compared with the unaided condition, speech recognition was significantly improved with the passive device. The device may also provide value to predict the hearing outcome with the implanted device, especially at higher intensities. Level of evidence: IV
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