1,721,053 research outputs found
Klassifikation und Analyse von Zertifizierungsmöglichkeiten für Produkte mit Schwerpunkt IT-Sicherheit
No full textAnalyse des Einflusses filmischer Verunreinigungen auf die Qualität daktyloskopischer Spuren
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Untersuchungen zur gerichtsverwertbaren Dokumentation forensischer Analysen virtueller Währungstransaktionen
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Analysis of agonists of the vascular endithelial growth factor receptor-3 (VEGFR-3) by using ligand- and structure based methods
No full textIn der heutigen Zeit gilt der Schlaganfall als die dritthäufigste Ursache für Langzeitschäden des Gehirns. Die dafür vorhandenen Therapiemöglichkeiten sind in ihrer Anwendung und zu erzielenden Ergebnisse begrenzt, sodass nach neuen Therapieansätzen gesucht wird. In dieser Arbeit wird eine mögliche Therapie auf Basis des vaskulären endothelialen Wachstumsfaktor Rezeptor-3 (VEGFR-3) thematisiert. Untersucht wurden dabei neben unterschiedlichen Kristallstrukturrefinementstrategien zur Verfeinerung und Optimierung der Proteinkristallstruktur des VEGFR-3 (PDB ID: 4BSK) auch die Entwicklung neuartiger Agonisten mit berechneter erhöhter Bindungsaffinität im Vergleich zum natürlichen Agonisten VEGF-C.At present stroke is considered to be the third most common cause of long-term damage to the brain. The available treatment options are thereby limited to their application and the curation results, so searching for new therapeutic approaches is the focus of several scientific projects. In this work a possible application based on the vascular endothelial growth factor receptor-3 (VEGFR-3) is discussed. Besides the study of different strategies for the refinement and optimization of the crystal structure of VEGFR-3, an approach for the development of new agonists was established, leading to compounds that share a higher calculated affinity to the receptor, compared to the natural ligand VEGF-C
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