330 research outputs found
Author response
No full textBlood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the ‘equilibrium signal’ in order to distinguish it from the ‘niche signal’. Earlier we showed that equilibrium signaling utilizes Pvr (the Drosophila PDGF/VEGF receptor), STAT92E, and adenosine deaminase-related growth factor A (ADGF-A) (Mondal et al., 2011). Little is known about how this signal initiates during hematopoietic development. To identify new genes involved in lymph gland blood progenitor maintenance, particularly those involved in equilibrium signaling, we performed a genetic screen that identified bip1 (bric à brac interacting protein 1) and Nucleoporin 98 (Nup98) as additional regulators of the equilibrium signal. We show that the products of these genes along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr
Pure Mafia - a novel about child labour, plus thesis and commentary
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This PhD in Creative Writing consists of three parts. The first part is a full-length novel, approximately 80K words, entitled Pure
Mafia. It is a drama about child labour and the Pakistani “carpet mafia”. This is
intertwined with the story of an unhappily married man undergoing a midlife crisis who
has an affair with a younger woman; the latter is instrumental to the main plot about
child labour. The book’s second main theme is British Pakistanis. An overarching theme
is abuse and exploitation, both personal and global, but ultimately of redemption and
renewal. The story is set in 2010/2011, mainly in London, England, with a middle
section in Lahore, Pakistan. The second part is an academic thesis, approximately 20K words, entitled Cheap Labour = Child Labour, on the main theme of the novel, child labour. It attempts to show that child labour is an inevitable consequence of cheap labour generally, and that the only way to tackle child labour is to address cheap labour. The thesis has been consciously and deliberately written as an objective, third person, standalone document and for this reason does not mention the novel. It is partly designed to fulfil the general
PhD criterion of demonstrating scholarship and research. The third part is a subjective, first person critical commentary, approximately 15K words, on the writing of the novel and the thesis, the connection between them, and the research context; it is entitled Pure Mafia: A critical commentary. It explains why
the main thesis is on child labour, rather than on the creative process or an English
Literature thesis; however, the commentary does include in some detail an insight into
the creative process, as well as a discussion of influences and tradition of writing. The final section of the commentary summarises this entire PhD’s original
contribution to knowledge
Optogenetic regulation of protein activity in live cell
No full textSignaling pathways extensively crosstalk among each other and result in different cellular phenotypes depending on the dynamic profile of protein activity. Conventional genetic and pharmacological approaches such as gene overexpression, use of growth factors or inhibitors have helped us delineate interaction maps of signaling components, however these techniques provide limited means to determine contribution of a target protein for specific cellular phenotype. Therefore, to find out the molecular mechanism for a cellular outcome, there is an urgent need for a tool that can specifically activate or inactivate a protein of interest and study it’s role towards a specific cell fate. Optogenetic techniques utilize light to control protein functions with high spatial and temporal resolution. Here, I First present a generalizable light modulated protein stabilization system (GLIMPSe) that enables target-independent optogenetic control of protein activities and minimizes the systematic variation embedded within different photoactivatable proteins. GLIMPSe was applied to control light-mediated post-translational stabilization of two distinct classes of proteins, phosphatase and kinase with rapid kinetics response. Second, I discuss role of speckle-type POZ protein (SPOP) in cell differentiation inhibition in PC12 and primary rat hippocampus neuron cell. Next, I combined the GLIMPSe system with the Sufu protein, a SPOP phenocopy and sonic hedgehog (Shh) signaling pathway inhibitor and generated the GLIMPSe-Sufu system for optogenetic inhibition of Shh signaling pathway. Finally, I review the molecular machinery of cargo trafficking with emphasis on new optogenetic and optochemical experimental strategies that enable direct modulation of cargo trafficking in live cells.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2022-05-01The student, Payel Mondal, accepted the attached license on 2020-05-01 at 14:55.The student, Payel Mondal, submitted this Dissertation for approval on 2020-05-01 at 15:01.This Dissertation was approved for publication on 2020-05-07 at 14:44.DSpace SAF Submission Ingestion Package generated from Vireo submission #15084 on 2020-08-25 at 17:41:15Made available in DSpace on 2020-08-27T00:50:04Z (GMT). No. of bitstreams: 4
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Agriculture Credit and Economic Growth in Bangladesh: A Time Series Analysis
No full textThe paper examined the impact of agricultural credit on economic growth in
Bangladesh. The annual data of agriculture credit were collected from annual
reports of the Bangladesh Bank and other data were collected from the world
development indicator (WDI) of the World Bank. By employing Johansen
cointegration test and vector error correction model (VECM), the study revealed
that there exists a long run relationship between the variables. The results of
the study showed that agriculture credit had a positive impact on GDP growth in
Bangladesh. The study also found that gross capital formation had a positive,
while inflation had a negative association with economic growth in Bangladesh.
Therefore, the government and policymakers should continue their effort to
increase the volume of agriculture credit to achieve sustainable economic
growth
An Empirical Analysis on Remittances and Financial Development in Latin American Countries
No full textRemittances have become one of the driving forces of development for
countries all over the world, especially in lower-middle-income nations. This
paper empirically investigates the association between remittance flows and
financial development in 4 lower-middle-income countries of Latin America. By
using a panel data set from 1996 to 2019, the study revealed that remittances
and financial development are positively associated in these countries. The
study also discovered that foreign direct investment and inflation were
positively correlated with financial development while trade openness had a
negative association with financial development. Therefore, policymakers of
these countries should implement and formulate such policies so that migrant
workers would have the incentives to send money through formal channels, which
will augment the effect of remittances on the recipient country
Reinforcement Learning-Based Design of Side-Channel Countermeasures
No full textDeep learning-based side-channel attacks are capable of breaking targets protected with countermeasures. The constant progress in the last few years makes the attacks more powerful, requiring fewer traces to break a target. Unfortunately, to protect against such attacks, we still rely solely on methods developed to protect against generic attacks. The works considering the protection perspective are few and usually based on the adversarial examples concepts, which are not always easy to translate to real-world hardware implementations. In this work, we ask whether we can develop combinations of countermeasures that protect against side-channel attacks. We consider several widely adopted hiding countermeasures and use the reinforcement learning paradigm to design specific countermeasures that show resilience against deep learning-based side-channel attacks. Our results show that it is possible to significantly enhance the target resilience to a point where deep learning-based attacks cannot obtain secret information. At the same time, we consider the cost of implementing such countermeasures to balance security and implementation costs. The optimal countermeasure combinations can serve as development guidelines for real-world hardware/software-based protection schemes.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
What Do You See? Transforming Fault Injection Target Characterizations
No full textIn fault injection attacks, the first step is to evaluate the target behavior for various fault injection parameters. Showing the results of such a characterization (commonly known as target cartography) is informative and allows researchers to assess the target’s behavior better. Additionally, it helps understand the performance of new search methods or attacks. Thus, publishing obtained results is essential to provide relevant information for reproducibility and benchmarking, improving state-of-the-art results and general security. Unfortunately, publishing the results also allows malicious parties to reverse engineer the information and potentially mount an attack easier. This work discusses how various transformations can be used to occlude sensitive information but, at the same time, still be useful for interested researchers. Our results show that even simple 2D transformations, such as rotation, scaling, and shifting, significantly increase the effort required to reverse engineer the transformed data but maintain the interesting data distribution. Consequently, this work provides a method to allow publishers to share more data in a confidential setting.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
Language and Cognitive Structures of Emotion [electronic resource] /
No full textThis book examines linguistic expressions of emotion in intensional contexts and offers a formally elegant account of the relationship between language and emotion. The author presents a compelling case for the view that there exist, contrary to popular belief, logical universals at the intersection of language and emotive content. This book shows that emotive structures in the mind that are widely assumed to be not only subjectively or socio-culturally variable but also irrelevant to a general theory of cognition offer an unusually suitable ground for a formal theory of emotive representations, allowing for surprising logical and cognitive consequences for a theory of cognition. Challenging mainstream assumptions in cognitive science and in linguistics, this book will appeal to linguists, philosophers of the mind, linguistic anthropologists, psychologists and cognitive scientists of all persuasions. Prakash Mondal is Assistant Professor of Linguistics and Cognitive Science at the Indian Institute of Technology Hyderabad. He is the author of Language, Mind and Computation (2014), Natural Language and Possible Minds (2016) and Language, Biology and Cognition (completed).Chapter I: Introduction: Intensionality and Emotive Expressions -- Chapter II: How the Intentional Content of Emotion can be Traced to the Intensionality of Emotive Expressions -- Chapter III: Emotive Intensionality, Meaning and Grammar -- Chapter IV: Toward an Architecture of the Language-Emotion Interface -- Chapter V: Conclusion.This book examines linguistic expressions of emotion in intensional contexts and offers a formally elegant account of the relationship between language and emotion. The author presents a compelling case for the view that there exist, contrary to popular belief, logical universals at the intersection of language and emotive content. This book shows that emotive structures in the mind that are widely assumed to be not only subjectively or socio-culturally variable but also irrelevant to a general theory of cognition offer an unusually suitable ground for a formal theory of emotive representations, allowing for surprising logical and cognitive consequences for a theory of cognition. Challenging mainstream assumptions in cognitive science and in linguistics, this book will appeal to linguists, philosophers of the mind, linguistic anthropologists, psychologists and cognitive scientists of all persuasions. Prakash Mondal is Assistant Professor of Linguistics and Cognitive Science at the Indian Institute of Technology Hyderabad. He is the author of Language, Mind and Computation (2014), Natural Language and Possible Minds (2016) and Language, Biology and Cognition (completed)
Multiplicative degree based topological indices of some chemical structures in drug
No full text© 2020 Murat Cancan, Sourav Mondal, Nilanjan De, and Anita Pal. This is an open acess article distributed under the terms of the Creative Commons License, which permits unrestricted use and distribution provided the original author and source are credited.In quantitative structure property relationship analysis (QSPR) and quantitative structure property relationship analysis (QSAR) the correlation between different properties/activities and molecular structure of chemical compounds is investigated which is helpful in drug design. Topological index is an useful tool to predict different physical and chemical properties of molecule by collecting information from the molecular graph. In this article, multiplicative degree based topological indices are obtained for some chemical structures widely used in drug design, especially in anticancer drug discovery. To visualize the indices, the results are interpreted graphically
Body, time, and the others: African-American anthropology and the rewriting of ethnographic conventions in the ethnographies by Zora Neale Hurston and Katherine Dunham
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This research looks at the ethnographies Mules and Men (1935) and Tell My Horse: Voodoo and Life in Haiti and Jamaica (1938) by Zora Neale Hurston focusing on representations of Time and the anthropologist’s body. Hurston was an African-American anthropologist, folklorist, and novelist who conducted research particularly between the end of the 1920s and the mid-1930s. At first, her fieldwork and writings dealt with African-American communities in Florida and Hoodoo practice in Louisiana, but she consequently expanded her field of anthropological interests to Jamaica and Haiti, which she visited between 1936 and 1937. The temporal and bodily factors in Hurston’s works are taken into consideration as coordinates of differentiation between the ethnographer and the objects of her research. In her ethnographies, the representation of the anthropologist’s body is analysed as an attempt at reducing temporal distance in ethnographical writings paralleled by the performative experience of fieldwork exemplified by Hurston’s storytelling: body, voice, and the dialogic representation of fieldwork relationships do not guarantee a portrayal of the anthropological subject on more egalitarian terms, but cast light on the influence of the anthropologist both in the practice and writing of ethnography. These elements are analysed in reference to the visualistic tradition of American anthropology as ways of organising difference and ascribing the anthropological ‘Others’ to a temporal frame characterised by bodily and cultural features perceived as ‘primitive’ and, therefore, distant from modernity. Representations and definitions of ‘primitiveness’ and ‘modernity’ not only shaped both twentieth-century American anthropology and the modernist arts (Harlem Renaissance), but also were pivotal for the creation of a modern African-American identity in its relation to African history and other black people involved in the African diaspora. In the same years in which Hurston visited Jamaica and Haiti, another African-American woman anthropologist and dancer, Katherine Dunham, conducted fieldwork in the Caribbean and started to look at it as a source of inspiration for the emerging African-American dance as recorded in her ethnographical and autobiographical account Island Possessed (1969). Therefore, Hurston’s and Dunham’s representations of Haiti are examined as points of intersection for the different discourses which both widened and complicated their understanding of what being ‘African’ and ‘American’ could mean.Isambard Research Scholarship from Brunel University and grant from Allan & Nesta Ferguson Charitable Trust
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