17,015 research outputs found
RDLS-SS-DWT v. 0.9
No full textThis fileset contains the implementation of RDLS-DWT and SS-DWT in JPEG 2000 (RDLS-SS-DWT v. 0.9), which was used in a research described in: R. Starosolski, “Application of reversible denoising and lifting steps to DWT in lossless JPEG 2000 for improved bitrates,” Signal Processing: Image Communication, Vol. 39, Part A, pp. 249-63, DOI: 10.1016/j.image.2015.09.013, 2015 and R. Starosolski, “Skipping selected steps of DWT computation in lossless JPEG 2000 for improved bitrates,” submitted. This software is intended for research purposes only; it is provided "as is"; author makes no warranty of any kind, either express or implied, with respect to this software. <br
A strategy for the determination of dopamine at a bare glassy carbon electrode: p-Phenylenediamine as a nucleophile
No full text[[abstract]]Electrochemical oxidation of dopamine (DA) in the presence of p-phenylenediamine (PPD) as a nucleophile in aqueous buffered solutions was studied. The results indicate that the o-dopaminoquinone (o-DQ) electrochemically derived from DA participates in 1,4-Michael addition with PPD to form the corresponding new derivative (P2), which is present as the oxidized state (Q2) at the electrolysis applied potential. This reaction pathway inhibits the cyclization of o-DQ and thus, the formation of polymerized films on the electrode surface. The reduction current for Q2 to P2 can be used to determine DA concentration. A selective sensing and quantitative determination of DA by adding PPD and using a bare glassy carbon electrode in the presence of a high concentration of ascorbic acid was verified. (c) 2006 Elsevier B.V. All rights reserved.[[note]]SC
Synthesis of tritium-labeled Lu-PSMA-617: Alternative tool for biological evaluation of radiometal-based pharmaceuticals
No full textThis project focuses on the generation and evaluation of functional alternatives to radiometal-based pharmaceuticals supporting basic research and the in vitro developmental phase. Employing robust tritium chemistry and non-radioactive metal surrogates in two synthetic and labeling strategies resulted in ([ring-3H]Nal)PSMA-617 and ([alpha,ss-3H]Nal)PSMA-617. In particular, ([alpha,ss-3H]Nal)Lu-PSMA-617 exhibited high radiolytic as well as metalcomplex stability and was compared to the clinically-established radiopharmaceutical [177Lu]Lu-PSMA-617. The cell-based assays confirmed the applicability of ([alpha,ss-3H]Nal)Lu-PSMA-617 as a substitute of [177Lu]Lu-PSMA617 in pre-clinical biological settings
Resonant indirect Fowler–Nordheim tunneling in Al0.8Ga0.2As barrier
No full textOscillatory current-voltage characteristics of n+-GaAs/semi-insulating Al0.8Ga0.2As/nGaAs heterojunction barriers (400 angstrom thick) grown by molecular beam epitaxy on n+-GaAs (100) substrates are observed at 4 K when the heterostructures are placed under the transverse uniaxial stress along [011] direction (perpendicular to current direction) above 4 kbar. We attribute these oscillations to the resonant indirect Fowler-Nordheim tunneling via [011] oriented transverse X valleys, where the change of wave vector is required for tunneling
Radiation affected compressible turbulent flow over a backward facing step
No full textA numerical analysis has been conducted to examine combined radiation-convection-conduction heat transfer over a backward facing step flow. The LU-SSOR scheme and finite volume method were used to solve the compressible Navier-Stokes equation and energy equation, while the radiative transfer equation was solved by discrete ordinates method (DOM). The thermal behavior has been influenced such that the fluid was heated up faster due to the radiation. Furthermore, the reattachment length was also shrunk because of the reduced adverse pressure gradient. However, the radiative heat flux was found to play some role in the recirculating zone only. Copyright (C) 1996 Elsevier Science Ltd.The authors are grateful for the financial support by ADD (Agency for Defense Development) under contract ATRC-421-940903
SS Northland Echo
No full textPhotograph - A view of the steamboat, SS Northland Echo on the Athabasca River. Athabasca, Albert
SS Athabasca River - 02
No full textPhotograph - A view of the SS Athabasca River paddle steamer on the river, Athabasca, Albert
Biodegradable mixed MPEG-SS-2SA/TPGS micelles for triggered intracellular release of paclitaxel and reversing multidrug resistance
No full textKai Dong,1 Yan Yan,2 Pengchong Wang,2 Xianpeng Shi,2 Lu Zhang,2 Ke Wang,2 Jianfeng Xing,2 Yalin Dong1 1Department of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Abstract: In this study, a type of multifunctional mixed micelles were prepared by a novel biodegradable amphiphilic polymer (MPEG-SS-2SA) and a multidrug resistance (MDR) reversal agent (D-α-tocopheryl polyethylene glycol succinate, TPGS). The mixed micelles could achieve rapid intracellular drug release and reversal of MDR. First, the amphiphilic polymer, MPEG-SS-2SA, was synthesized through disulfide bonds between poly (ethylene glycol) monomethyl ether (MPEG) and stearic acid (SA). The structure of the obtained polymer was similar to poly (ethylene glycol)-phosphatidylethanolamine (PEG-PE). Then the mixed micelles, MPEG-SS-2SA/TPGS, were prepared by MPEG-SS-2SA and TPGS through the thin film hydration method and loaded paclitaxel (PTX) as the model drug. The in vitro release study revealed that the mixed micelles could rapidly release PTX within 24 h under a reductive environment because of the breaking of disulfide bonds. In cell experiments, the mixed micelles significantly inhibited the activity of mitochondrial respiratory complex II, also reduced the mitochondrial membrane potential, and the content of adenosine triphosphate, thus effectively inhibiting the efflux of PTX from cells. Moreover, in the confocal laser scanning microscopy, cellular uptake and 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assays, the MPEG-SS-2SA/TPGS micelles achieved faster release and more uptake of PTX in Michigan Cancer Foundation-7/PTX cells and showed better antitumor effects as compared with the insensitive control. In conclusion, the biodegradable mixed micelles, MPEG-SS-2SA/TPGS, could be potential vehicles for delivering hydrophobic chemotherapeutic drugs in MDR cancer therapy. Keywords: reversal of multidrug resistance, reduction-sensitive, disulfide bond, mixed micelles, MCF-7/PTX cell
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