73 research outputs found
Abstract P1-10-10: Tumor infiltrating lymphocytes (TILS) among high risk for recurrence breast cancer patients treated with tetrathimolybdate (TM)
No full textAbstract
Background: Tumor infiltrating lymphocytes (TILs) evaluated in the primary tumor biopsy or surgical resection have been well established as having prognostic significance in patients with triple negative breast cancer (TNBC) and HER2+ breast cancer treated with adjuvant chemotherapy (Savas et. al, Nat Rev Clin Oncol 2016). In TNBC, stromal TILs behave as a continuous variable with every 10% increase in TIL resulting in a decrease in risk of recurrence and death. The definition of lymphocyte-predominant breast cancer (LPBC) has been used for tumors that contain 50%–60% TILs and usually have a particularly good outcome (Salgado et al, Ann Oncol 2015). Our group recently demonstrated in a phase II single arm study that tetrathimolybdate (TM), a copper-depleting agent, resulted in improved event free survival (EFS) for TNBC patients compared to historical controls. The 2-year event-free survival (EFS) for stage 2-3 and stage 4 NED was 91% and 67%, respectively. In this analysis, our goal was to explore whether the encouraging results we observed were influenced by enrolling TNBC patients with better prognostic factors at initial diagnosis, namely higher stromal TIL score, in our copper depletion trial.
Methods: Archived primary breast tissue was available from 67 of the 75 patients enrolled in the phase II TM trial. The phase II study included patients with stage II TNBC or stage III or IV NED breast cancer patients, who were treated with TM for 2 years or until relapse. Here we focused on the 30 patients with TNBC. The demographic data for the patients is included in the following table.
Patient DemographicsAge at diagnosisStage at study entryPrior Adjuvant or Neoadjuvant therapyNumber of prior chemotherapy regimens in metastatic setting%Tumor Infiltrating Lymphocytes504Adjuvant110543AAdjuvantn/a30563AAdjuvantn/a20513CNeoadjuvantn/a<5454Adjuvant230514Neoadjuvant210363CAdjuvantn/a20592BAdjuvantn/a60453CAdjuvantn/a<5544Adjuvant130443CNeoadjuvantn/a20474Adjuvant020563CNeoadjuvantn/a10512AAdjuvantn/a10583AAdjuvantn/a20654None25513CNeoadjuvantn/a50503CNeoadjuvantn/a30543CNeoadjuvantn/a10542AAdjuvantn/a20403CNeoadjuvantn/a40604Adjuvant160564None160554Adjuvant010633CNeoadjuvantn/a5424Adjuvant050454Adjuvant110463AAduvantn/a10523CNeoadjuvantn/a10514Adjuvant1<5
The number of TILs in each sample was calculated by an experienced pathologist using published criteria (Salgado et al, Ann Oncol 2015). We used TILs >50% to define LPBC.
Results: Overall, we found that only 3/30 (10%) of TNBC patients had TILs >50%. In addition, 14/30 (46.7%) of TNBC patients had tumors with <10% TILs. The 2-year EFS for the patients with TILs >10% v. <10% was 76.9% v. 69.8%, respectively. (P=0.65)
Conclusions: Only 10% of TNBC patients enrolled in the study had LPBC at diagnosis thus indicating that this cohort was not enriched for patients with immunogenic tumors. When stratified by TILs >10% or <10%, there was no statistically significant difference in EFS. Although the analysis is limited due to the small sample size, it does suggest that the amount of TILs present at initial diagnosis did not influence the overall outcome for patients treated with TM.
Citation Format: Rybstein MD, Nackos E, Kornhauser N, Cigler T, Andreopoulou E, Moore A, Cobham M, Fitzpatrick V, Demaria S, Vahdat LT. Tumor infiltrating lymphocytes (TILS) among high risk for recurrence breast cancer patients treated with tetrathimolybdate (TM) [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P1-10-10.</jats:p
Phase II Clinical Trial of Ixabepilone (BMS-247550), an Epothilone B Analog, in Patients With Taxane-Resistant Metastatic Breast Cancer
No full textPURPOSE:
Ixabepilone (BMS-247550) is an epothilone analog that optimizes the properties of naturally occurring epothilone B. Natural epothilones and their analogs promote tumor cell death by binding to tubulin and stabilizing microtubules, causing apoptosis. This international phase II trial assessed the activity of ixabepilone in patients with metastatic breast cancer (MBC) that was resistant to taxane therapy.
PATIENTS AND METHODS:
MBC patients, who had experienced disease progression while receiving or within 4 months of taxane therapy (6 months if adjuvant taxane only), and who had a taxane as their last regimen, received ixabepilone (1- or 3-hour infusion of 50 mg/m(2) or 3-hour infusion of 40 mg/m(2) every 3 weeks).
RESULTS:
Of 49 patients treated with 40 mg/m(2) ixabepilone during 3 hours, 35 (73%) had experienced disease progression within 1 month of their last taxane dose. The response rate was 12% (95% CI, 4.7% to 26.5%). All responses (n = 6) were partial; five of six patients had not responded to prior taxane therapy. In responders, the median response duration was 10.4 months. In 20 patients (41%), stable disease was the best outcome. Median time to progression was 2.2 months (95% CI, 1.4 to 3.2 months); median survival was 7.9 months. For treated patients across all cohorts (intent-to-treat population), the response rate was also 12% (eight of 66). Treatment-related adverse events in the study were manageable and primarily grade 1/2. Treatment-related neuropathy was mostly sensory and mild to moderate.
CONCLUSION:
Ixabepilone (40 mg/m(2) as a 3-hour infusion every 3 weeks) demonstrates promising antitumor activity and an acceptable safety profile in patients with taxane-resistant MBC
Seminário Acadêmico Caminhos Para Inclusão Produtiva Rural - Edição Nordeste
No full text<p>Cycles of Academic Seminars Paths for Rural Productive Inclusion conducted by the Brazilian Network for Research and Management in Territorial Development (RETE)</p>
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<p>Ciclos de Seminários Acadêmicos Caminhos para Inclusão Produtiva Rural conduzido pela Rede Brasileira de Pesquisa e Gestão em Desenvolvimento Territorial (RETE)</p>
Mudanças climáticas, valorização da biodiversidade e inclusão produtiva rural
No full text<p>Under what conditions can the emergence of the valorization of biodiversity favor productive inclusion in rural areas? How can the production of new knowledge and the building of institutional capacities help to improve the quality of public debate and the decision-making process? The next seminar of the Itinerant Chair on Rural Productive Inclusion seeks to answer these questions. The meeting is scheduled for June 11, at 10 a.m., at the Cebrap networks.</p>
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<p>Sob que condições a emergência da valorização da biodiversidade pode favorecer a inclusão produtiva em áreas rurais? Como a produção de novos conhecimentos e a construção de capacidades institucionais podem ajudar a melhorar a qualidade do debate público e do processo de tomada de decisões? O próximo seminário da Cátedra Itinerante Inclusão Produtiva Rural busca responder essas perguntas. O encontro está marcado para o dia 11/6, às 10h, nas redes do Cebrap.</p>
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Geometric reconstruction of Amir‐Chakhmagh Square through backward‐perspective
No full textPurposeGeometry, as the visual depiction of mathematics, has always comprised a major communicative language in architecture. Thus, geometry has traditionally been taught in architectural education to produce the perspective view of spaces from plans and elevations. This process is understood as a move from the actual to the abstract. The purpose of this paper is to show how the author has applied the geometry of perspective backwards to generate, from photos, the 3D reconstruction of a space that no longer exists.Design/methodology/approachWhat are the original form and the morphological evolution of Amir‐Chakhmagh Square? To address this question, the author processed photos of the square through geometric simulation. After verifying that the photos are taken from the same square, the author developed a geometrical reconstruction process to come up with the plan and elevations of the spaces, which is enough to reconstruct the 3D model. Finally, by virtue of these documents, the author analyzed the historical evolution of the square.FindingsThe main contribution of this research is recreating the architectural plans of the square, as well as introducing a simple method to extract plans and elevations from a given perspective.Originality/valueThe case study presented is the Amir‐Chakhmagh Square in the historic core of Yazd‐Iran. This square with an adjacent bazaar is one of the most important urban spaces of Iran, and was partially demolished in the modernizations of the 1920s. The need to renovate the remains of the square has called for new attempts to understand its original form.</jats:sec
Mohammad Khatami The Philosopher President
No full textIn his speech at the UN General Assembly in September 1998, Mohammad Khatami proposed to analyse the principle elements of American culture in terms of Puritan history and influence. Similarly, in an interview with CNN, he invoked Tocqueville’s Democracy in America to highlight the religious foundations of American democracy, a gesture that caused a vexatious envy among some American politicians and political pundits. In this essay the author argues that such references reflect not just Khatami’s erudition but also highlight central tenets in his political philosophy.
A systematic review of applications of machine learning and other soft computing techniques for the diagnosis of tropical diseases
No full textThis systematic literature aims to identify soft computing techniques currently utilized in diagnosing tropical febrile diseases and explore the data characteristics and features used for diagnoses, algorithm accuracy, and the limitations of current studies. The goal of this study is therefore centralized around determining the extent to which soft computing techniques have positively impacted the quality of physician care and their effectiveness in tropical disease diagnosis. The study has used PRISMA guidelines to identify paper selection and inclusion/exclusion criteria. It was determined that the highest frequency of articles utilized ensemble techniques for classification, prediction, analysis, diagnosis, etc., over single machine learning techniques, followed by neural networks. The results identified dengue fever as the most studied disease, followed by malaria and tuberculosis. It was also revealed that accuracy was the most common metric utilized to evaluate the predictive capability of a classification mode. The information presented within these studies benefits frontline healthcare workers who could depend on soft computing techniques for accurate diagnoses of tropical diseases. Although our research shows an increasing interest in using machine learning techniques for diagnosing tropical diseases, there still needs to be more studies. Hence, recommendations and directions for future research are proposed.Peer reviewedsystematic revie
مقایسه ساختار و عملکرد قلب پسران ورزشکار نخبه کشتی با غیرورزشکاران شهر اردبیل: ساختار و عملکرد قلب کشتی گیران
No full textمقدمه: فعالیت ورزشی شدید و مداوم موجب تغییرات سازگاری در ساختار و عملکرد قلب میگردد که به پدیده «قلب ورزشکار» شناخته میشود. هدف از این پژوهش، مقایسه شاخصهای ساختاری، سیستولیک و دیاستولیک قلب پسران ورزشکار نخبه کشتی با همسالان غیرورزشکار بود.
روش کار: در این مطالعه مقطعی، ۴۰ پسران جوان سالم (۲۰ ورزشکار نخبه کشتی و ۲۰ غیرورزشکار) شرکت کردند. ارزیابی قلب با استفاده از اکوکاردیوگرافی داپلر دوبعدی در حالت استراحت انجام شد. برای مقایسه گروهها، آزمون t مستقل و تحلیل کوواریانس (ANCOVA) با کنترل سن و شاخص توده بدنی (BMI) بهکار رفت.
یافته ها: نتایج نشان داد ورزشکاران نخبه دارای توده بطن چپ (195 ± 18 g در برابر 158 ± 15 g ؛ p<0.001)، کسر تزریقی بالاتر (64.5 ± 3.2% در برابر 60.1 ± 3.5%؛ p<0.001)، و حجم ضربهای بیشتر بودند. علاوه بر آن، شاخصهای دیاستولیک شامل نسبت E/A بالاتر (1.7 ± 0.2)، نسبت ′E/e پایینتر (7.1 ± 1.1) و IVRT کوتاهتر (70 ± 8 ms) بیانگر شلشدگی مؤثرتر میوکارد بودند. نتایج پس از تعدیل برای سن و BMI نیز معنادار باقی ماندند.
نتیجه گیری: این یافتهها نشان میدهد تمرینات منظم و شدید کشتی موجب هیپرتروفی فیزیولوژیک، بهبود عملکرد انقباضی و پرشدگی قلبی میشود؛ بهطوری که قلب ورزشکاران نخبه از کارایی بالاتر و سازگاری مطلوبتری نسبت به افراد غیرورزشکار برخوردار است
Study text of Ishaq Khajesi Ahmad Vahdetnamah Âlam-Engiz
No full textBu çalışmanın amacı, Vahdet-name-i Âlem-Engiz Mesnevisi'nin tenkitli metninin kurulması ve oluşturulan sağlam metin üzerinden eserin şekil ve içerik yönünden incelenmesidir. Bu gaye doğrultusunda, öncelikle eseri meydana getiren yazarın içinde yaşadığı XVII ve XVIII. yüzyıl; siyasi, sosyal, kültürel ve edebi yönüyle ele alınmıştır. Ardından İshak Hocası'nın hayatı ve eserleri hakkında bilgi verilmiştir. Bu tetkikler neticesinde, şairin görüşleri hakkında elde edilen ipuçlarından da faydalanılarak eser incelemesinin yapıldığı birinci bölüme geçilmiştir. Birinci bölümde, Vahdet-name şekil ve muhteva yönüyle incelenmiştir. Mesnevi, şairin takip ettiği sıra ve kullandığı kavramlar üzerinden tahlile çalışılmıştır. İkinci bölümde ise, Vahdet-name-i Âlem-Engiz'in ulaşılabilen nüshaları üzerinden şecere oluşturma ve tenkitli metin kurma çalışmaları yürütülmüştür. Tezin genel bir değerlendirmesinin yapıldığı sonuç ile çalışma bitirilmiştir. The aim of this thesis is to edit a criticial text and to study the text in point of form and content. For that purpose, the period which shaped the author was studied in the light of political, social, cultural and literarial aspects. Next, information was presented about life and works of Ishaq Khajesi and dealed following the clues of views of the poet. In the first part, Vahdat-namah was analyzed from the point of form and content. Mathnawi was studied taking into account the order which the poet followed and the concepts which he used. In the second chapter, geneology and edition of critical text was constructed using available copies of Vahdat-namah Âlam-Engiz. The study was completed with the chapter of conclusion in which a general asessment was made
نحوه گذراندن اوقات فراغت در شرایط قرنطینه خانگی برای جلوگیری از ابتلا به کووید 19 مطالعه موردی؛ کشتیگیران شهر اردبیل
No full textBackground and aim: In December 2019, the prevalence of a viral disease was reported in Wuhan, China. Due to the high contagion power, it spread rapidly and infected almost all the countries of the world in a relatively short period (less than four months). It also caused the lockdown and quarantine of societies and cities. Hence, the aim of the present study was to scrutinize the way wrestlers spend their free time in quarantine time to prevent COVID-19.
Methods: The statistical population of this study included wrestlers in the age group of adolescents, youth, and adults in Ardabil. A sample of 340 individuals was selected. The research instruments were a questionnaire including demographic information and a researcher-made leisure questionnaire. Data were analyzed by descriptive statistics, t-test, and ANOVA using SPSS22 software with the significant level of P < 0.05.
Results: The outcomes of the present study demonstrated that wrestlers allocated on average less than 2 hours of their time to the leisure components and there was no statistically significant relationship between demographic variables and the total score of how they spent their leisure time (p < 0.05).
Conclusion: Finally, if the existing condition continues, regarding less mobility and quarantine and the diseases increase due to inactivity of individuals will increase the costs of treatment and will affect all the health-centered policies of the countries. Therefore, it is required to inform and educate planning for leisure time, not only in the field of sports but also in other fields and subcomponents of leisure through media and social media networks.سابقه و هدف: در دسامبر 2019 میلادی انتشار یک بیماری ویروسی در شهر ووهان چین گزارش شد و به دلیل قدرت سرایت بسیار بالا به سرعت انتشار پیدا کرد و تقریبا طی زمانی اندک (کمتر از چهار ماه) تمامی کشورهای جهان را آلوده و باعث تعطیلی و قرنطینه جوامع و شهرها شد. بنابراین هدف از مطالعه حاضر، بررسی نحوه گذران اوقات فراغت کشتیگیران در شرایط قرنطینه خانگی برای جلوگیری از کووید 19 بود.
روش کار: جامعه آماری این پژوهش شامل کشتیگیران رده سنی نوجوانان، جوانان و بزرگسالان شهرستان اردبیل بود. 340 نفر به عنوان نمونه انتخاب شدند. ابزار پژوهش، پرسشنامه شامل اطلاعات دموگرافیک و پرسشنامه اوقات فراغت ساخته محقق بود. دادهها با استفاده از آزمونهای آمار توصيفي، آزمون t و ANOVA با استفاده از نرمافزار SPSS ویرایش 22 در سطح معنيداري p < 0.05 تجزيه و تحليل شدند.
یافتهها: یافتههای پژوهش حاضر نشان دادند که، ورزشکاران بهطور متوسط کمتر از 2 ساعت از وقت خود را به مولفههای اوقات فراغت اختصاص دادند و نتایج تجزیه و تحلیل آماری حاکی از آن بود که بین متغیرهای دموگرافیک و نمره کل نحوه گذراندن اوقات فراغت، ارتباط آماری معناداری وجود نداشت (p < 0.05).
نتیجهگیری: در نهایت در صورت تداوم وضع موجود، با توجه به کمتحرکی و قرنطینه خانگی و افزایش بیماریهای ناشی از کمتحرکی افراد، هزینههای درمان افزایش یافته و تمامی سیاستهای سلامت محور کشورها را تحتتاثیر قرار خواهد داد. بنابراین نیاز است که برنامهریزی در اوقات فراغت نه تنها در زمینه ورزش بلکه در همه زمینهها و زیرمولفههای اوقات فراغت از طریق رسانهها و شبکههای اجتماعی و ... اطلاعرسانی و آموزش داده شود
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