1,720,971 research outputs found
Effects of the brominated flame retardant tetrabromobisphenol-A (TBBPA) on cell signaling and function of Mytilus hemocytes: involvement of MAP kinases and protein kinase C
No full textA new technology with potential interest for conservation of cultural heritage: vaporized hydrogen peroxide sterilisation (VHPS)
Full text linkThe VHPS technology can be considered as a safer and more environmentally friendly method for decontamination of works of art, and environments, colonized by microorganisms (fungi, bacteria). The application of this technology allowed that: • the procedure has to be performed on site; • the procedure has to be repeated in several runs; • the procedure has to perform microbial biocide and sporocide; • the human toxicity has to be controllable (safe working environment); • the gaseous mixture has to avoid creating a cumulative chemical toxic burden; • the validation and reproducibility of the decontamination process. In the present work we put together the information coming from the application of sterilization procedure from different field such as medicine, pharmacology, nanotechnology, in order to develop new applicative protocols, particularly for cultural heritage field
Interactions between Mytilus haemocytes and different strains of Escherichia coli and Vibrio cholerae O1 El Tor: role of kinase-mediated signalling
No full textEffects of tumour necrosis factor alpha (TNFalpha) on Mytilus haemocytes: role of stress-activated mitogen-activated protein kinases (MAPKs
No full textEnvironmental estrogens can affect the function of mussel hemocytes through rapid modulation of kinase pathways
No full textImmunomodulation of Mytilus hemocytes by individual estrogenic chemicals and environmentally relevant mixtures of estrogens: in vitro and in vivo studies
No full textEffects of blood lipid lowering pharmaceuticals (bezafibrate and gemfibrozil) on immune and digestive gland functions of the bivalve mollusc, Mytilus galloprovincialis
No full textEndocrine Disruptors in marine organisms: approaches and perspectives
No full textOrganic pollutants exhibiting endocrine disrupting activity (Endocrine Disruptors—EDs) are prevalent over a wide range in the aquatic ecosystems; most EDs are resistant to environmental degradation and are considered ubiquitous contaminants. The actual potency of EDs is low compared to that of natural hormones, but environmental concentrations may still be sufficiently high to produce detrimental biological effects.
Most information on the biological effects and mechanisms of action of EDs has been focused on vertebrates. Here we summarize recent progress in studies on selected aspects of endocrine disruption in marine organisms that are still poorly understood and that certainly deserve further research in the near future. This review, divided in four sections, focuses mainly on invertebrates (effects of EDs and mechanisms of action) and presents data on top predators (large pelagic fish and cetaceans), a group of vertebrates that are particularly at risk due to their position in the food chain. The first section deals with basic pathways of steroid biosynthesis and metabolism as a target for endocrine disruption in invertebrates. In the second section, data on the effects and alternative mechanisms of action of estrogenic compounds in mussel immunocytes are presented, addressing to the importance of investigating full range responses to estrogenic chemicals in ecologically relevant invertebrate species. In the third section we review the potential use of vitellogenin (Vtg)-like proteins as a biomarker of endocrine disruption in marine bivalve molluscs, used worldwide as sentinels in marine biomonitoring programmes. Finally, we summarize the results of a recent survey on ED accumulation and effects on marine fish and mammals, utilizing both classical biomarkers of endocrine disruption in vertebrates and non-lethal techniques, such as nondestructive biomarkers, indicating the toxicological risk for top predator species in the Mediterranean. Overall, the reviewed data underline the potential to identify specific types of responses to specific groups of chemicals such as EDs in order to develop suitable biomarkers that could be useful as diagnostic tools for endocrine disruption in marine invertebrates and vertebrates
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