196,290 research outputs found
Nuove indagini nell'insediamento Fenicio e Punico di Pani Loriga di Santadi, Carbonia Iglesias
No full textNuove indagini nell’insediamento fenicio e punico di Pani Loriga di Santadi, Carbonia-Iglesia
Synthesis and in vitro antitumor activity of new quinoxaline derivatives
No full textA series of novel 5,7-diamino-3-phenyl-2-benzylamino, 2-phenoxy, and 2-thiophenyl substituted quinoxalines has been designed, synthesized and evaluated for their in vitro antitumor activity towards cell lines of nine different types of human cancers. Some of these compounds exhibited inhibitory effects on the growth of a wide range of cancer cell lines generally at 10(-6) M, in some cases at 10(-7) M and 10(-8) M concentrations. Within this series the benzylamino quinoxaline derivatives 1b-7b were the most active, whereas compound 2c showed the highest MG_MD value (-5.66)
Essere e diventare umani: forme della reciprocità
No full textIl contributo della riflessione filosofica al tema della formazione umana è esplorato in un confronto di paradigmi tra classicità e modernità, attorno al quale si sviluppano tre linee di riflessione: il passaggio dalla teleologia all'archeologia del soggetto; il passaggio dall'antropocentrismo al biocentrismo; l'approfondimento dell'idea di reciprocità asimmetrica
Quinoxaline chemistry. Part 14. 4-(2-quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-L-glutamates as analogues-homologues of classical antifolate agents. Synthesis and evaluation of in vitro anticancer activity
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Quinoxaline Chemistry. Part 17. 4[3,6(7) disubstituted-2-quinoxalinyl-oxa]phenylacetate and phenylacetylglutamate analogues of methotrexate: Synthesis and evaluation of in vitro anticancer activity
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