4,143 research outputs found
Behind the scenes : the politics of planning Adelaide
No full textBehind the Scenes examines planning in the City of Adelaide from 1972 until 1993 within the historical framework of City/State relations from 1836 when the Province of South Australia was founded. During this 21-year period, the City had its own planning and development control legislation separate from the rest of the State. Dr Llewellyn-Smith examines why this situation came about, why it continued for this particular period and why it ceased in 1993 when the separate legislation was repealed and the City became part of the State system under the new Development Act 1993. Behind the Scenes includes original interviews with many of the key individuals in the City and State who played influential roles during this period. Dr Llewellyn-Smith himself was the City Planner from 1974 until 1981 and then the Town Clerk/Chief Executive Officer of the Adelaide City Council from 1982 until 1993: this book, then, is both a work of scholarship and an insider’s account. With a joint foreword by The Hon. Jay Weatherill MP, Premier of South Australia, and The Rt Hon. the Lord Mayor of Adelaide, Mr Stephen Yarwood.Michael Llewellyn-SmithList of Figures and Tables - Abbreviations - Acknowledgements - Foreword - Introduction - 1 The background to the founding of Adelaide and South Australia in 1836 - 2 The development of the City and State from 1840 until 1950 and the City/State relationship during this period - 3 Changing attitudes to planning the City and State from 1950 until 1972 - 4 The establishment of the City of Adelaide Development Committee and the introduction of Interim Development Control - 5 Planning in Sydney and the work of George Clarke - 6 The City of Adelaide Planning Study - 7 Converting the City of Adelaide Planning Study into a City Plan - 8 An innovative system of city planning from 1 March 1977 - 9 Changes in the ACC and the State, and the first Heritage Study of the City - 10 The operation of the City’s planning system from November 1982 until May 1987 - 11 The Condous Lord Mayoralty and the declining importance of the City of Adelaide Planning Commission - 12 The State Planning Review, the last City Plan and the end o the City’s separate system - Conclusion - Appendix 1 Key People of Influence identified as potential interviewees - Appendix 2 Heritage Summary Assessment Sheet - Bibliography - Inde
Will biological agents supplant systemic glucocorticoids as the first-line treatment for thyroid-associated ophthalmopathy?
No full textIn this article, the two authors present their opposing points of view concerning the likelihood that glucocorticoids will be replaced by newly developed biological agents in the treatment of active, moderate-to-severe thyroid-associated ophthalmopathy (TAO). TAO is a vexing, disfiguring and potentially blinding autoimmune manifestation of thyroid autoimmunity. One author expresses the opinion that steroids are nonspecific, frequently fail to improve the disease and can cause sometimes serious side effects. He suggests that glucocorticoids should be replaced as soon as possible by more specific and safer drugs, once they become available. The most promising of these are biological agents. The other author argues that glucocorticoids are proven effective and are unlikely to be replaced by biologicals. He reasons that while they may not uniformly result in optimal benefit, they have been proven effective in many reports. He remains open minded about alternative therapies such as biologicals but remains skeptical that they will replace steroids as the first-line therapy for active, moderate-to-severe TAO without head-to-head comparative clinical trials demonstrating superiority. Despite these very different points of view, both authors are optimistic about the availability of improved medical therapies for TAO, either as single agents or in combination. Further, both agree that better treatment options are needed to improve the care of our patients with active moderate-to-severe TAO
The value of silence
No full textThis is an electronic version of the article published in Theatre Journal, 54(1):85-94, 2002 March. The published article is available at http://muse.jhu.edu/journals/theatre_journal/v054/54.1eng.pdfEng, David L.The Value of Silence.Theatre Journal, 54,(1):85-94, 2002.DOI: 10.1353/tj.2002.000
Serum leptin and risk of cognitive decline in elderly italians.
No full textBackground: US studies suggest that leptin, a fat-derived hormone, may be protective against the development of dementia. Objective: To investigate the complex relationship between leptin levels and cognitive decline in elderly Italians. Methods: We studied circulating fasting leptin levels in 809 elderly adults free from dementia who participated in the prospective Italian population-based InCHIANTI study between 1998 and 2009 (mean follow-up of 8.0 years). Global cognitive decline was defined as a reduction of ≥5 points on the Mini-Mental State Examination (MMSE). Trail-Making Tests A and B were also incorporated, with cognitive decline defined as discontinued testing or the worst 10% of change from baseline. We also investigated whether any association could be explained by midlife weight and whether cognitive decline was associated with changing leptin levels. Results: The multivariate adjusted relative risk ([RR]; 95% confidence interval [CI]) of cognitive decline on the MMSE was 0.84 (95% CI 0.73–0.97) in relation to baseline sex-standardized log-leptin levels. High leptin levels showed a non-significant trend toward a reduced risk of decline on the Trail-Making Tests A (RR = 0.85, 95% CI 0.71–1.02) and B (RR = 0.90, 0.79–1.02). Adjusting for midlife weight or change in weight did not alter the pattern of results, and cognitive decline was not associated with changing leptin levels. Conclusions: High leptin levels were independently associated with a reduced risk of cognitive decline in elderly Italians.Italian Ministry of HealthU.S. National Institute on AgingAlzheimer’s AssociationNational Institute for Health Research (NIHR)National Institute of Health (Baltimore)National Institute of Health (Maryland)Mary Kinross Charitable TrustJames Tudor FoundationHalpin TrustSir Halley Stewart TrustAge Related Diseases and Health TrustNorman Family Charitable Trus
Liftings for noncomplete probability spaces
No full textThe current state of knowledge concerning liftings for noncomplete probability spaces is discussed. This is a somewhat expanded version of the author's talk given at the 1991 Summer Conference on General Topology and Applications in Honor of Mary Ellen Rudin and Her Work.PT: S; CR: BURKE MR, IN PRESS P AM MATH S BURKE MR, 1991, ISRAEL J MATH, V73, P33 BURKE MR, 1992, ISRAEL J MATH, V79, P289 CARLSON T, THEOREM LIFTING CHRISTENSEN JPR, 1974, TOPOLOGY BOREL STRUC FREMLIN DH, 1989, HDB BOOLEAN ALGEBRAS, P877 INOESCUTULCEA A, 1966, 5TH P BERK S MATH ST, V2 IONESCUTULCEA A, 1967, CONTRIBUTIONS PROB 1, P63 IONESCUTULCEA A, 1969, TOPICS THEORY LIFTIN JECH TJ, 1978, SET THEORY JOHNSON RA, 1980, P AM MATH SOC, V80, P234 JUST W, IN PRESS T AM MATH S KUPKA J, 1983, INDIANA U MATH J, V32, P717 LOSERT V, 1983, LNM, V1080, P95 MAHARAM D, 1958, P AM MATH SOC, V9, P987 SHELAH S, 1983, ISRAEL J MATH, V45, P90 TALAGRAND M, 1982, P AM MATH SOC, V84, P379 VONNEUMANN J, 1931, CRELLES J MATH, V165, P109; NR: 18; TC: 0; J9: ANN N Y ACAD SCI; PG: 4; GA: BZ86BSource type: Electronic(1
Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies
No full textThe current microdevices used for biomedical research are often manufactured using microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may not reflect the actual physiology of the microcirculation. Here, we present a simple method to fabricate circular polydimethysiloxane (PDMS) microchannels aiming to mimic an in vivo microvascular environment and suitable for state-of-the-art microscale flow visualization techniques, such as confocal µPIV/PTV. By using a confocal µPTV system individual red blood cells (RBCs) were successfully tracked trough a 75 µm circular PDMS microchannel. The results show that RBC lateral dispersion increases with the volume fraction of RBCs in the solution, i.e. with the hematocrit
The Imaging of a Complete Biological Structure with the Scanning Tunneling Microscope
No full textPT: J; CR: 1986, IBM J RES DEV, V30 AMREIN M, 1988, IN PRESS J MICROSCOP AMREIN M, 1988, SCIENCE, V240, P514 BEVERIDGE TJ, 1985, J BACTERIOL, V162, P728 BEVERIDGE TJ, 1987, CAN J MICROBIOL, V33, P725 BINNIG G, 1982, HELV PHYS ACTA, V55, P726 BLACKFORD BL, 1987, REV SCI INSTRUM, V58, P1343 BLACKFORD BL, 1988, IN PRESS J MICROSCOP DAHN DC, 1988, J VAC SCI TECHNOL A, V6, P548 FOSTER JS, 1988, IN PRESS J MICROSCOP HANSMA PK, 1987, J APPL PHYS, V61, R1 LINDSAY SM, 1988, J VAC SCI TECHNOL A, V6, P544 SHAW PJ, 1985, J BACTERIOL M, V161, P650 SMITH D, 1988, IN PRESS J MICROSCOP SMITH DPE, 1987, P NATL ACAD SCI USA, V84, P969 SONNENFELD R, 1986, SCIENCE, V232, P211 SPROTT GD, 1980, CAN J MICROBIOL, V26, P115 SPROTT GD, 1986, CAN J MICROBIOL, V32, P847 STEMMER A, 1987, SURF SCI, V181, P394 STEWART M, 1985, J MOL BIOL, V183, P509 STROSCIO JA, 1987, PHYS REV LETT, V58, P1668 ZASADZINSKI JAN, 1988, SCIENCE, V239, P1013; NR: 22; TC: 12; J9: ULTRAMICROSCOPY; PG: 6; GA: AA937Source type: Electronic(1
Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
No full textThe application of a 1H nuclear magnetic resonance (NMR) spectroscopy-based screening method for determining the use of two widely available analgesics (acetaminophen and ibuprofen) in epidemiologic studies has been investigated. We used samples and data from the cross-sectional INTERMAP Study involving participants from Japan (n = 1145), China (n = 839), U.K. (n = 501), and the U.S. (n = 2195). An orthogonal projection to latent structures discriminant analysis (OPLS-DA) algorithm with an incorporated Monte Carlo resampling function was applied to the NMR data set to determine which spectra contained analgesic metabolites. OPLS-DA preprocessing parameters (normalization, bin width, scaling, and input parameters) were assessed systematically to identify an optimal acetaminophen prediction model. Subsets of INTERMAP spectra were examined to verify and validate the presence/absence of acetaminophen/ibuprofen based on known chemical shift and coupling patterns. The optimized and validated acetaminophen model correctly predicted 98.2%, and the ibuprofen model correctly predicted 99.0% of the urine specimens containing these drug metabolites. The acetaminophen and ibuprofen models were subsequently used to predict the presence/absence of these drug metabolites for the remaining INTERMAP specimens. The acetaminophen model identified 415 out of 8436 spectra as containing acetaminophen metabolite signals while the ibuprofen model identified 245 out of 8604 spectra as containing ibuprofen metabolite signals from the global data set after excluding samples used to construct the prediction models. The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling
Values as reasons for consumer decisions – an inter-cultural comparison
No full textNowadays, consumers usually do not just consider the functional use of a product. At least equally important are the emotional experiences that are tied up with the product and that are sated with non-material elements of a product. Which non-material elements of a product are considered important by the consumer, depends on his or her personal values. Therefore, the identification of personal values assists in explaining the consumers’ purchasing motives. Since personal values do not just influence a consumers’ purchasing decision but vary between cultural circles, it is expected that cultural values lead to culture-specific consumption patterns. To analyse the coherences between cultural values and the consumer behaviour of a cultural circle, 40 female wine consumers, comprised of 20 German and 20 Ukrainian women, were interviewed on the basis of Means-End-Chain-Theory using laddering-interviews. The initial findings of this qualitative survey will be presented in this poster.Means-End-Chain-Theory, cross-cultural comparison, wine consumers, Consumer/Household Economics,
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