1,721,095 research outputs found
Alfa-interferon in the treatment of essential thrombocythemia: clinical results and evaluation ofits biological effects on the hematopoietic neoplastic clone. Italian Cooperative Group on Essentyal Thrombocytemia
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Difficult diagnostic and therapeutic cases: CASE 1. true thymic hyperplasia in a patient treated for T-cell lymphoma
No full textNATURALLY OCCURRING AND THERAPY-INDUCED ANTIBODIES TO HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) IN HUMAN SERUM
No full textSera were obtained from two groups of patients. Group A included 7 patients
with low-grade non-Hodgkin's lymphoma treated with three or more cycles of
standard-dose chemotherapy and recombinant human granulocyte-colony stimu-
lating factor (rhG-CSF). The cytokine was administered to half the patients after
the ®rst chemotherapy cycle and to the other half after the second according to
a randomized design and then to all patients from the third chemotherapy cycle
on, until documented hemopoietic reconstitution. Group B included 3 patients
with high-grade non-Hodgkin's lymphoma, 1 patient with resistant Hodgkin's
disease, and 1 patient with multiple myeloma who received high-dose chemotherapy
and rhG-CSF. Anti-G-CSF antibodies were detected in the sera of 4
patients. Both immunoglobulin IgM and IgG antibodies were detected at low
levels in pretreatment sera from one group A patient. IgG antibody titers increased
markedly during the ®rst and second periods of G-CSF administration. IgG class
antibodies developed in 3 group B patients during the ®rst course of rhG-CSF administration.
Circulating anti-G-CSF antibodies did not seem to affect hematological recovery.
Low levels of anti-G-CSF antibodies were also detected in sera (15/135) from
different healthy adults and in sera (5/40) from umbilical cord blood. Saturable
antibody binding and competition enzyme-linked immunosorbent assay (ELISA) and
immunoblotting con®rmed antibody speci®city
Natural and therapy-induced anti-GM-CSF and anti-G-CSF antibodies in human serum
No full textSerum samples were obtained from patients with lymphoid and plasma cell malignancies who received after chemotherapy human recombinant GM-CSF or G-CSF. Sera from some patients revealed the presence of anti-cytokine antibodies, particularly after repetitive cytokine injections. Antibody Fab binding in a saturable manner by ELISA and Western immuno-blotting confirmed antibody specificity. Anti-cytokine antibodies were detected before the exogenous cytokine injections in some patients, but increasing antibody levels were found after one or subsequent treatments. Low levels of anti-GM-CSF and anti-G-CSF antibodies were also detected in a relatively large proportion (about 10-30%) of normal sera from different adult healthy volunteers who had never been treated before with exologous cytokines as well as from cord blood. EBV-immortalized cord blood derived B-cell cultures were also found to produce anti GM-CSF and/or anti-G-CSF antibodies with high frequency
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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