1,721,018 research outputs found
Diagnostic markers of chronic hepatitis B infection and disease”
No full textRecent advances in therapy for patients with chronic hepatitis B (CHB) infection
offer the potential for a more successful treatment outcome, but also raise a
number of questions in clinical practice regarding diagnosis and staging of CHB
to ensure such potential is realized. In patients without cirrhosis, some forms
of antiviral therapy can switch patients from an active disease phase into an
inactive hepatitis B surface antigen (HBsAg) carrier state, and eventually lead
to HBsAg clearance and HBsAg antibody seroconversion, the closest to a cure in
CHB; thus, one of the most important diagnostic questions that clinicians face is
the identification of patients with early forms of CHB within a large cohort of
asymptomatic HBsAg-positive individuals, most of whom are inactive HBsAg
carriers. Two major categories of diagnostic markers are currently available:
virus-specific markers and liver disease markers. Most markers involve the use of
non-invasive serological testing, but invasive diagnostic procedures, such as
liver biopsy, are also an option. In this article, we review current opinions on
the appropriate use of diagnostic procedures, answering some important questions
for the clinician, such as why, how, when and in whom they might best be used
Changes of Serum HBV DNA in Relation to Serum Transaminase Level During Acute Exacerbation in Patients with Chronic Type B Hepatitis
No full textThe Etiology of Acute Hepatitis Superimposed upon Previously Unrecognized Asymptimatic HBsAg Carriers
No full textThe Role of Hepatitis C Virus Infection in Spontaneous Hepatitis B Surface Antigen Clearnace During Chronic Hepatitis B Virus Infections
No full textChanges of Serum HBV DNA in Two Types of Clinical Events Preceding Spontaneous Hepatitis B e antigen Seroconversion in Chroinic Type B Hepatitis
No full textScreening of Hepatitis B Virus in Healthy Blood Ndonors by Molecular DNA Hybridization Analysis
No full textAnalysis on the Status of Hepatitis B Virus DNA in Peripheral Blood Mononuclear Cells of Chronic Hepatitis B Patients
No full textThe Clinical Outcome of Hepatitis C Virus Antibody - Positive Renal Allograft Recipients
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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