280 research outputs found
Our glorious dead [music] : memorial song to British Empire /
No full textCover title.; "This beautiful song should be sung on all memorial occasions it is dedicated to our heroes who fell in the great war".; Also available online http://nla.gov.au/nla.mus-an5528003; N, M 160818
The Critics : Rabbitt Like Pretty Automatons
No full textThe first article is a duplicate of an item forming part of hy-dm-news-reviews-michell-1977-001The article containing information about Brian Finch and Kenny Henson has been underlined in red pen.Item located in file hy-dm-finch-henson-1947-2007-001. Not all items in folder uploaded.The first article pertains to a concert featuring Rabbitt/ 5000 Volts and Brian Finch with Kenny Henson at the Film Trust Arena whereby the author reflects on all the musicians, points out the faults and provides praise where warranted. The second article refers to the same concert which took place at the Arena the previous evening. Apart from mentioning some commendable points of the evening, the author discusses the shortfalls attached to the Rabbitt performance and points out the similarities between the Henson and finch performance compared to their previous appearances
A strain tensor method for three-dimensional optimal Michell structures
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, 2016.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 94-95).In the design of discrete structures such as trusses and frames, important quantitative goals such as minimal weight or minimal compliance often dominate. Many numerical techniques exist to address these needs. However, an analytical approach exists to meet similar goals, which was initiated by A.G.M. Michell (1904) and has been mostly used for two-dimensional structures so far. This thesis develops a method to extend the existing mainly two-dimensional approach to apply to three-dimensional structures. It will be referred as the Michell strain tensor method (MSTM). First, the proof that MSTM is consistent with the existing theory in two dimensions is provided. Second, two-dimensional known solutions will be replicated based on MSTM. Finally, MSTM will be used to solve new three- dimensional cases.by Benjamin Jacot.M. Eng
Voltage imbalances mitigation in electrical distribution networks using synchronverters as power supply for distributed generation
No full textilustraciones, diagramasMediante esta tesis se desarrolla un método de control en cascada para la integración de generación distribuida a redes eléctricas, cuya tensión se encuentra desequilibrada. Estas redes son comunes en sistemas de distribución ya que, se suele encontrar desequilibrios de tensión causados por la presencia de cargas monofásicas y bifásicas, o generación monofásica fotovoltaica que, desequilibran el consumo de potencia en la red. Se propone un modelo modificado de Synchronverter (Sincro-convertidor) capaz de sincronizarse a una red desbalanceada, con el fin de entregar potencia activa y reactiva a la red, y dar soporte de tensión y frecuencia. Pasada la etapa de conexión del sincro-convertidor, se disminuye el porcentaje de desequilibrio por presencia de secuencia negativa en el punto común de conexión (PCC). Lo anterior se logra utilizando la descomposición en componentes simétricas en función del tiempo, con especial atención a las secuencias positiva y negativa. El control propuesto se enfoca en un control flexible de secuencias positiva y negativa, y entrega potencia en ambas secuencias con la finalidad de reducir la componente negativa en la tensión del PCC. Con esto se logra reducir el porcentaje de desequilibrio de tensión calculado a partir del estándar técnico IEEE 1159-2019. Las simulaciones se llevan a cabo en el Toolbox Simulink® de Matlab® versión 2022a [1], con un modelo de generador distribuido único conectado a una carga local y una red desbalanceada, representada por una fuente de tensión trifásica con diferentes valores de tensión en cada una de sus fases. Los resultados son satisfactorios, ya que se logra una disminución en el porcentaje de desbalance en el PCC. (Texto tomado de la fuente)Through this thesis, a cascaded control method is developed for the integration of distributed generation to electrical networks, where the voltage is unbalanced. These networks are common in distribution systems since voltage imbalances are usually found caused by the presence of single-phase and two-phase loads, single-phase photovoltaic generation, that unbalance the power consumption in the network. A modified model of the Synchronverter capable of synchronizing to an unbalanced network is proposed, to deliver active and reactive power to the network and provide voltage and frequency support. After the connection stage of the synchronverter, the unbalance percentage is reduced due to the presence of a negative sequence in the common connection point (PCC). This is achieved using time-symmetric component decomposition, with special attention to positive and negative sequences. The proposed control focuses on a flexible control of positive and negative sequences and delivers power in both sequences to reduce the negative component in the PCC voltage. With this, it is possible to reduce the percentage of voltage unbalance calculated from the technical standard IEEE 1159-2019. The simulations are carried out in the Matlab® Simulink® version 2022a [1] Toolbox with a single distributed generator model connected to a local load and an unbalanced network, represented by a three-phase voltage source with different voltage values in each of its phases. The results are satisfactory, since a decrease in the percentage of imbalance in the PCC is achieved.DoctoradoDoctor en IngenieríaEnergías Alternativas y Desarrollo de Nuevos ProcesosÁrea curricular de Ingeniería Química e Ingeniería de Petróleo
Phenotypic Characterisation of Clostridium Difficile Strains Defective in Lipoprotein Biosynthesis
No full textClostridium difficile
is regarded as the primary etiological agent of antibiotic
-
associated diarrhoea, posing a significant challenge
to healthcare facilities. The
changing nature of
C. difficile
infection
is causing an increase in
associated
disease
occurrence
outside of the healthcare setting and a
gradual move away
from the historical
association with antimicrobial treatment. Adhesio
n of spores
and vegetative cells to host gut epithelium is thought to be a key aspect of
C.
difficile
virulence; disruption of this process may significantly reduce the impact
of an infection and the likelihood of infection spread. Lipoproteins are involve
d
in adhesion of
C. difficile
to host tissues
and may have roles in other key
aspects of virulence.
Lipoproteins
undergo a specific biosynthesis process
within the bacterial cell involving addition of an acyl
-
glyceryl moiety by
lipoprotein glyceryl transfe
rase (Lgt) followed by signal peptide cleavage by
lipoprotein signal peptidase (LspA); disruption of
this
process may cause
attenuation of virulence and
a
reduction in adhesion
to host tissue
.
C. difficile
has been shown to encode two functional and homolo
gous lipoprotein signal
peptidases: LspA and LspA2.
The novel antimicrobials globomycin and
myxovirescin directly target lipoprotein signal peptidases and therefore may
have potential for use in treatment of
C. difficile
infection.
Evaluation of their
effi
cacy against LspA and LspA2 can be determined by protection assays using
Escherichia coli
strains expressing LspA or LspA2 from
C. difficile
.
In this study, both LspA and LspA2 from
C. difficile
are shown to contain the
consensus sequences, domains and
in
silico
predicted tertiary structure
expected of lipoprotein signal peptidases. Characteris
ation of
C. difficile
strains
with silencing mutations in either
lspA
or
lspA2
,
in
comparison to a wild type
,
reveals that the absence of either lipoprotein signal pe
ptidase causes an
increased survivability in hydrogen peroxide and may affect protein
localis
ation
within the bacterium.
Finally, successful
cloning of
C. difficile lspA
and
lspA2
and subsequent expression of LspA and LspA2 via auto
-
induction in
E. coli
is
reported, paving the way for further investigation into the effect of globomycin or
myxovirescin treatment
On the Possession of Truth in Fiction: A.S. Byatt's Confrontation with the Role of the Author
No full textWhen Possession’s protagonist, a post-structuralist/deconstructionist scholar named Roland Michell, finds and takes drafts of a letter written by Victorian poet Randolph Henry Ash, A.S. Byatt re-opens the longstanding debate concerning the ownership of truth and an author’s role in textual interpretation, ultimately asking: Who owns the meaning of a text? And even more so, why? The act of theft from the private world of an author (and the journey it spurs) allows Possession to coincide with pre-formalist notions about the author—that the author and their life is central to the meaning of their work—despite a dominant knowledge of formalism, new criticism, structuralism, poststructuralism, and deconstruction in the contemporary timeline. However, Possession’s three-and-a-half-page postscript chapter unravels a novel-length endorsement of pre-formalist notions, affording the novel a neutral existence that does not condemn nor encourage reliance on the biography of the author. As a result, this essay finds that the novel acts as a means for readers to identify two fundamental ideas about authorship and to witness a regressive transition from a post- to pre-formalist literary approach. In fact, by depicting the common occurrence of exchange to curate an author’s belongings (despite their passing), Possession even suggests that the reconfiguration of the author is a response to capitalist commodification. And so, by utilizing the theories of Roland Barthes and Michel Foucault, this essay argues how Possession shows the role of capitalism and consumerism in the contemporary approach to literature
The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells
No full text1. Temporal changes in the levels of many inositol phosphates, whose structural characterization is presented in the preceding paper [Wong, Barker, Morris, Craxton, Kirk and Michell (1991) Biochem. J. 286, 459 468], have been monitored in vasopressin-stimulated WRK-1 cells. 2. Upon stimulation, Ins(1,4,5)P3 accumulated within 1 s, consistent with its role as a rapidly acting second messenger produced by receptor activation of phosphoinositidase C. Ins(1,4)P2 and Ins(1,3,4,5)P4, both of which are immediate products of Ins(1,4,5)P3 metabolism, also accumulated quickly. Ins4P, Ins(1,3,4)P3, Ins(3,4)P2, Ins(1,3)P2, Ins1P and Ins3P, which are intermediates in the metabolism of Ins(1,4)P2 and Ins(1,3,4,5)P4 to inositol, accumulated after seconds or within a few minutes, and in a temporal sequence consistent with their known metabolic interrelationships. 3. The stimulated accumulation of Ins(1,3,4,6)P4 was delayed, as expected if it is formed by phosphorylation of Ins(1,3,4)P3. 4. Ins(3,4,5,6)P4 accumulated 2-3-fold in a few minutes, and mainly before Ins(1,3,4,6)P4. 5. Using a [3H]-/[14C]-inositol double-labelling protocol, we obtained evidence that all of the compounds that accumulated upon stimulation, except Ins(3,4,5,6)P4, originated from lipid-derived Ins(1,4,5)P3, but that the newly formed Ins(3,4,5,6)P4 came from a different source. 6. There were no consistent changes in the levels of Ins(1,3,4,5,6)P5 and InsP() during stimulation. 7. Alongside the gradual accumulation of Ins(1:2-cyclic,4,5)P3 during stimulation [Wong, Barker, Shears, Kirk and Michell (1988) Biochem. J. 252, 1-5], there was an accumulation of Ins(1:2-cyclic,4)P2 and Ins(1:2-cyclic)P, probably as either minor side products of phosphoinositidase C action or metabolites of Ins(1:2-cyclic,4,5)P3. 8. When Li+ was present during stimulation, it redirected the dephosphorylation pathways downstream of Ins(1,4,5)P3 in the manner expected from its inhibition of inositol monophosphatase and Ins(1,4)P2/Ins(1,3,4)P3 1-phosphatase: there were marked increases in the accumulation of Ins(1,4)P2 and Ins(1,3,4)P3 and of monophosphates. Moreover, Li+ shifted the Ins1P/Ins3P balance in favour of Ins1P, thus demonstrating redirection of the metabolism of the accumulated Ins(1,3,4)P3 towards Ins(1,3)P2 rather than Ins(3,4)P2.</p
Interactions between wavemaking and the boundary layer and wake of a ship model
No full textA detailed experimental study has been conducted in a towing tank on a 3.048-meter-long mathematical model, known as the Wigley hull, to study the effects of viscosity on the wavemaking resistance of the ship form. The measurements included total resistance, viscous resistance, pressure distribution, and boundary-layer measurements of the model at zero trim and sinkage. The three-dimensional boundary-layer measurements extend from midship to a distance of 0.1 model lengths downstream of the stern and include the pressure distribution on the body, and three components of the mean velocity measured by means of a five-hole pitot tube. These measurements were carried out for four Froude numbers of 0.266, 0.313, 0.350 and 0.400. A numerical method, using the small-crossflow approximation of the boundary-layer equations, has been employed to calculate the boundary-layer characteristics along the streamlines on the hull which were obtained by using Guilloton's methode A comparison between calculation and experimental results has been made. The wave-resistance coefficients of the ship form have been calculated by the Michell integral, using the Michell thin-ship centerplane distribution, a hull surface distribution and a slender-body centerplane distribution. These calculations have been carried out for two different cases, 1) wave resistance calculation without the effect of the boundary layer and wake, and 2) calculations including these effects. These calculations have been carried out only to first order and have been compared with the residuary resistance and the wave-profile resistance
Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-trisphosphate
Full text linkWe have augmented our previous studies [Storey, Shears, Kirk & Michell (1984) Nature (London) 312, 374-376] on the subcellular location and properties of Ins(1,4,5)P3 (inositol 1,4,5-trisphosphate) phosphatases in rat liver and human erythrocytes. We also investigate Ins(1,3,4)P3 (inositol 1,3,4-trisphosphate) metabolism by rat liver. Membrane-bound and cytosolic Ins(1,4,5)P3 phosphatases both attack the 5-phosphate. The membrane-bound enzyme is located on the inner face of the plasma membrane, and there is little or no activity associated with Golgi apparatus. Cytosolic Ins(1,4,5)P3 5-phosphatase (M(r) 77000) was separated by gel filtration from Ins(1,4)P2 (inositol 1,4-bisphosphate) and inositol 1-phosphate phosphatases (M(r) 54000). Ins(1,4,5)P3 5-phosphatase activity in hepatocytes was unaffected by treatment of the cells with insulin, vasopressin, glucagon or dibutyryl cyclic AMP. Ins(1,4,5)P3 5-phosphatase activity in cell homogenates was unaffected by changes in [Ca2+] from 0.1 to 2 μM. After centrifugation of a liver homogenate at 100000 g, Ins(1,3,4)P3 phosphatase activity was largely confined to the supernatant. The sum of the activities in the supernatant and the pellet exceeded that in the original homogenate. When these fractions were recombined, Ins(1,3,4)P3 phosphatase activity was restored to that observed in unfractionated homogenate. Ins(1,3,4)P3 was produced from Ins(1,3,4,5)P4 (inositol 1,3,4,5-tetrakisphosphate) and was metabolized to a novel InsP2 that was the 3,4-isomer. Ins(1,3,4)P3 phosphatase activity was not changed by 50 mM-Li+ or 0.07 mM-Ins(1,4)P2 alone, but when added together these agents inhibited Ins(1,3,4)P3 metabolism. In Li+-treated and vasopressin-stimulated hepatocytes, Ins(1,4)P2 may reach concentrations sufficient to inhibit Ins(1,3,4)P3 metabolism, with little effect on Ins(1,4,5)P3 hydrolysis.</p
A Goonful of Spike's Factory
No full textItem located in file hy-dm-parker-milligan-1976-1980-001Article includes an underlined section in red.The author of the newspaper article reflects on his first hand experience of a show hosted by Spike Milligan at the Colosseum. He raves about his talent and encourages readers to attend one of his performances. The article also mentions additional supporting acts which had greatly impressed the author
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