1,721,498 research outputs found

    Drug-receptor binding kinetics in drug discovery: Sticking around at the histamine H1 receptor

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    Leurs, R. [Promotor]Vischer, H.F. [Copromotor

    Pharmacological Characterization of Novel Histamine H4 Receptor Ligands

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    Leurs, R. [Promotor]Vischer, H.F. [Copromotor

    Exploring the Chemokine Receptor CXCR2: Ligand Recognition and Response

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    Leurs, R. [Promotor]Smit, M.J. [Promotor

    Dimerization and signaling of the chemokine receptors CXCR3 and CCX-CKR

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    Leurs, R. [Promotor]Vischer, H.F. [Copromotor

    Trypanosoma brucei phosphodiesterase B1 as a drug target for Human African Trypanosomiasis

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    Leurs, R. [Promotor]Esch, I.J.P. de [Promotor

    Design and Synthesis of New Histamine H4 Receptor Ligands

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    Leurs, R. [Promotor]Esch, I.J.P. de [Copromotor

    Molecular aspects of the histamine H1 receptor

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    Leurs, R. [Promotor]Bakker, R.A. [Copromotor

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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