1,720,986 research outputs found
Valutazione dell’effetto immunomodulante ed antiossidante di una formulazione commerciale a base di Shitake, Uncaria e Ribes
No full textComposizione e proprietà biologiche di estratti di Sideritis syriaca da campioni spontanei dell’appennino centrale
No full textEffect of Montepulciano d’Abruzzo red wine and main phenols on mouse skeletal muscle cells
No full textA pharmacy students survey on knowledge and use of medicinal plants.
No full textISBN: 978-989-95050-1-
A natural formulation (imoviral) increases macrophage resistance to LPS-induced oxidative and inflammatory stress in vitro.
No full textImoviral is a natural product formulation containing a mixture of uncaria, shiitake and ribes extracts. All ingredients are recognized as antioxidant, anti-inflammatory agent and immunomodulant. In order to evaluate the rational basis of extract mixture as immunomodulatory agent, we tested the effect of Imoviral formulation on macrophage response to lipopolysaccharide (LPS)-induced stress. The effect was evaluated as variation of reactive oxygen species (ROS) and prostaglandin E2 (PGE2) production and as cytokine gene expression. The extract did not affect cell viability up to 250μg/ml. Treatment with extract (10-150 μg/ml) reduced ROS and PGE2 production as well as IL-8 and TNF-α gene expression. A pre-treatment with extract blunted LPS-induced production of ROS and PGE2, markers of oxidative and inflammatory stress, as well as the gene expression of all cytokines tested, indicators, in vitro, of immune response activation. In conclusion, we demonstrated that Imoviral formulation could be a useful tool to modulate the immune function, reducing the oxidative and inflammatory markers related to bacterial attack. Experimental data suggest that Imoviral extract mixture could also represent a preventive pharmacological strategy to enhance cell resistance to bacterial infections
In vitro inhibitory activity of essential oil of Apium nodiflorum against Helicobacter pylori
No full textA multifraction extract of Chamomile as modulator of inflammatory and immune response markers on isolate rat colon.
No full textAntioxidant activity of methanol extract of Helichrysum foetidum Moench
No full textMethanol extract of Helichrysum foetidum Moench (Asteraceae) was investigated for antioxidative properties. The antioxidant activities were investigated by 2,20-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging, β-carotene/linoleic acid assay, scavenging of hydrogen peroxide (HRPO test), superoxide anion scavenging (S.A.S. test) and hypochlorous acid scavenging (taurine test). The antioxidant activity was reported as IC50 and reveals Trolox-like antioxidative effects
A natural formula containing lactoferrin, Equisetum arvensis, soy isoflavones and vitamin D3 modulates bone remodeling and inflammatory markers in young and aged rats.
No full textA pivotal role in osteoporosis development is played by radical oxygen species (ROS), the increased production of which is related to inhibited osteoblastic activity and bone formation. A new field of research could involve medicinal plants with antioxidant and protective effects in osteoporosis. Furthermore, considering the multifactorial metabolic aspects of osteoporosis, the pharmacological association of multiple medicinal plants could improve patient response. The aim of the present study is to evaluate in vitro and in vivo the protective effects of a natural formula containing lactoferrin 12%, Equisetum arvensis ES 54%, soy isoflavones 34% and vitamin D3 0.002%, in PBMC and C2C12 cells and in the bone matrix of young (3-month-old) and aged (12-month-old) female Sprague-Dawley rats, following chronic (21 days) administration. In this context, we assayed the activities of several inflammation and bone homeostasis mediators, such as IL-6, TNFα, PGE2, osteoprotegerin, RANK, RANKL and NFkB. In vitro studies showed that natural formula (5-1000μg/ml) was able to significantly inhibit ROS and PGE2 production. In the same concentration range, the natural formula inhibited both TNFα and IL-6 gene expression. In the in vivo studies, we administered to young and aged female rats the natural formula at 5mg/rat for 21 days, finding a significant reduction in inflammatory PGE2 and NFkB activity. Nevertheless, we observed a significant increase in osteoprotegerin/RANKL ratio only in aged rats, compared to the respective control group. In conclusion, our findings corroborate the rational use of natural formula in the prevention and management of osteoporotic disease
Use and awareness of medicinal plant and phytotherapy among undergraduate students at School of Pharmacy - University of Chieti, Italy
No full textAims: To investigate the awareness and the use of herbal products among undergraduate students of the School of Pharmacy in Chieti.
Study Design: From October 2013 to December 2013, students of the School of Pharmacy at University “G. d’Annunzio” in Chieti were invited by e-mail to respond to an online questionnaire about their knowledge and their personal experience in the use of herbal products. The filling of the questionnaire was possible through a specific Italian website. Anonymity and autonomy of the answers were fully guaranteed. The multi tasks online questionnaire was articulated in three main parts: demographic information, awareness of phytotherapy, and personal experience in the use of herbal products.
Results: A total of 548 questionnaires were collected. The age range of the students was between 18 and 31 years and they were mainly women (74.5%), which were also the typical herbal users (occasional use of complex herbal remedies to treat different diseases). Most herb usage was self-prescribed and undisclosed to physician, but under professional suggestion of pharmacist or herbalist.
Conclusion: Although some misconceptions about definition of phytotherapy and herb-based products were detected, undergraduate students result informed about perspective of use of herbal remedies. The use is wide distributed and the perception of usefulness is positive, as confirmed by strong interest in the continuous use. The use of herbal products without medical prescription could be consider as a potential health risk, but taking into account the health indications, the occasional use, and the strong influence of healthcare professionals suggestions, the use of phytotherapy could be considered as quite safe in the population studied. This study highlights the importance for the “pharmacists of the future” to have a good professional training in the field of medicinal plants (and phytotherapy) during the degree course in Pharmacy
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