1,721,096 research outputs found
Murine cytomegalovirus induces expression and enzyme activity of cellul dihidrofolate reductase in quiescent cells
No full textConjunctive queries with negation over DL-Lite: a closer look
Full text linkWhile conjunctive query (CQ) answering over DL-Lite has been studied extensively, there have been few attempts to analyse CQs with negated atoms. This paper deepens the study of the problem. Answering CQs with safe negation and CQs with a single inequality over DL-Lite with role inclusions is shown to be undecidable, even for a fixed TBox and query.Without role inclusions, answering CQs with one inequality is P-hard and with two inequalities CoNP-hard in data complexity
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Polynomial conjunctive query rewriting under unary inclusion dependencies
Full text linkOntology-based data access (OBDA) is widely accepted as an important ingredient of the new generation of information systems. In the OBDA paradigm, potentially incomplete relational data is enriched by means of ontologies, representing intensional knowledge of the application domain. We consider the problem of conjunctive query answering in OBDA. Certain ontology languages have been identified as FO-rewritable (e.g., DL-Lite and sticky-join sets of TGDs), which means that the ontology can be incorporated into the user's query, thus reducing OBDA to standard relational query evaluation. However, all known query rewriting techniques produce queries that are exponentially large in the size of the user's query, which can be a serious issue for standard relational database engines. In this paper, we present a polynomial query rewriting for conjunctive queries under unary inclusion dependencies. On
the other hand, we show that binary inclusion dependencies do not admit
polynomial query rewriting algorithms
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Early inhibitors of human cytomegalovirus: State-of-art and therapeutic perspectives.
No full textHuman cytomegalovirus (HCMV) infection is associated with severe morbidity and mortality in immunocompromised individuals, mainly transplant recipients and AIDS patients, and is the most frequent cause of congenital malformations in newborn children. To date, few drugs are licensed for the treatment of HCMV infections, most of which target the viral DNA polymerase and suffer from many drawbacks, including long-term toxicity, low potency, and poor bioavailability. In addition, the emergence of drug-resistant viral strains is becoming an increasing problem for disease management. Finally, none of the current anti-HCMV drugs have been approved for the treatment of congenital infections. For all these reasons, there is still a strong need for new anti-HCMV drugs with novel mechanisms of action. The first events of the virus replication cycle, including attachment, entry, immediate-early gene expression, and immediate-early functions-in particular that of Immediate-Early 2 protein-represent attractive targets for the development of novel antiviral compounds. Such inhibitors would block not only the expression of viral immediate-early proteins, which play a key role in the pathogenesis of HCMV infection, but also the host immunomodulation and the changes to cell physiology induced by the first events of virus infection. This review describes the current knowledge on the initial phases of HCMV replication, their validation as potential novel antiviral targets, and the development of compounds that block such processes
A novel approach to controlled query evaluation in DL-Lite
Full text linkIn Controlled Query Evaluation (CQE) confidential data are protected through a declarative policy and a (optimal) censor, which guarantees that answers to queries are maximized without disclosing secrets. In this paper we consider CQE over Description Logic ontologies and study query answering over all optimal censors. We establish data complexity of the problem for ontologies specified in DL-LiteR and for variants of the censor language, which is the language used by the censor to enforce the policy. In our investigation we also analyze the relationship between CQE and the problem of Consistent Query Answering
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