1,721,032 research outputs found
Tachykinin activation of human monocytes from normal and rheumatoid patients: effects of cyclosporine
No full textCyclosporin A reduces tachykinin activation of human monocytes from normal and rheumatoid arthritis patients
No full textAutomated Hardware Design Methodology for Digital Filters with High-Level Synthesis
Full text linkThe increasing complexity of digital hardware systems and the demand for faster time-to-market for the semiconductor industry require a rapid and flexible design strategy at an increased abstraction level. To this end, we propose a fully automated hardware design methodology for digital signal processing (DSP) applications such as digital filters, using high-level synthesis (HLS) integrated with MATLAB. This approach enables a one-click workflow from concept design to a synthesized and functionally verified netlist, with the requirement of minimal hardware expertise. After comparison with industry standard register transfer level (RTL) designs of multiple filter architectures, the area of HLS-generated implementations exhibited a variance ranging from a 54.4 % reduction to a 35.8 % overhead. This indicates a comparable quality of results (QoR), especially when weighed against the significant gains in design time reduction and productivity. Beyond digital filters, the work demonstrates that modern HLS tools, when paired with automation and parameterized code, can deliver rapid industrial grade ASIC results, bridging the gap between algorithm development and hardware deployment in digital signal processing and beyond
Neural Networks for Indoor Person Tracking With Infrared Sensors
Full text linkIndoor localization has many pervasive applications, like energy management, health monitoring, and security. Tagless localization detects directly the human body, like passive infrared sensing, and is the most amenable to different users and use cases. We evaluate the localization and tracking performance, as well as resource and processing requirements of various neural network (NN) types using directly the data from a low resolution 16-pixel thermopile sensor array in a 3 m x 3 m room. Out of the multilayer perceptron, autoregressive, 1D-CNN, and LSTM NN architectures that we test, the latter require more resources but can accurately locate and capture best the person movement dynamics, while the 1D-CNN provides the best compromise between localization accuracy (9.6 cm RMSE) and movement tracking smoothness with the least resources, and seem more suited for embedded applications
Tachykinin activation of human monocytes from patients with rheumatoid arthritis: in vitro and ex-vivo effects of cyclosporin A
No full textThree types of tachykinin receptors, namely NK1, NK2 and NK3, are known to preferentially interact with substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), respectively. We previously demonstrated that NK1 and NK2 receptors are present on human monocytes, SP and NKA inducing superoxide anion production and tumor necrosis factor- alpha (TNF-alpha) mRNA expression. NK2 receptor stimulation also triggered an enhanced respiratory burst in monocytes isolated from rheumatoid arthritis (RA) patients. This study was aimed to evaluate the in vitro and ex-vivo effects of cyclosporin A (CsA) on tachykinins-evoked TNF-alpha release from monocytes of healthy donors and RA patients. CsA (100 ng/ml) potently inhibited phorbol ester- and tachykinin-evoked TNF-alpha secretion. In RA patients treated with CsA (Sandimmun(R) Neoral(R)) 2.5 mg/kg/die, a significant time-dependent reduction in TN F-or secretion from monocytes was measured. This may contribute to the CsA therapeutic activity in RA
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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