491 research outputs found
Sex versus survival: The life and ideas of Sabina Spielrein
No full textWho was Sabina Spielrein? Her dramatic life story is most famous for her notorious affair with Carl Jung, dramatised in the film A Dangerous Method starring Keira Knightley. Yet she was a woman who overcame family and psychiatric abuse to become an original thinker in the field of psychotherapy. This is the first biography to put her life and ideas at the centre of the story, and to examine Spielreins key role in the development of psychoanalysis and in the rift between Jung and Freud. Drawing on fresh research into Spielreins diaries, papers and correspondence, John Launer tells the story of a passionate woman who transformed herself from one of Jungs disturbed patients into a leading figure in Western psychology, then the Soviet intelligentsia, before losing her life in the Holocaust. At the heart of Sex Versus Survival is the gripping tale of Spielrein and Jungs tumultuous affair, which played such an important role in both of their lives and intellectual journeys. Launer shows how Spielreins overlooked ideas rejected by Jung and Freud, but substantially vindicated by later developments in psychology and evolutionary biology may represent the last and most important stage in the rediscovery of an extraordinary life
Medial temporal lobe atrophy on MRI: vascular risk factors and predictive value for dementia
No full textBarkhof, F. [Promotor]Scheltens, P. [Promotor]Launer, L.J. [Copromotor
Dietary intake and the risk of dementia and cognitive decline in population-based studies
No full textDietary intake and the risk of dementia and cognitive decline in population-based studies
No full text
Оцінка когнітивних функцій у хворих з ізольованою систолічною артеріальною гіпертензією в практиці сімейного лікаря
No full textЗ віком в популяції збільшується кількість пацієнтів з ізольованою
систолічною артеріальною гіпертензією (ІСАГ). Взаємозв’язок між високим артеріальним тиском (АТ) і розладами когнітивних функцій (КФ)
встановлений у багатьох епідеміологічних дослідженнях: The Framingham
Heart Study, Hoorn Study, Uppsala Longitudinal Study of Adult Men, ARIC,
Honolulu-Asia Aging Study. Результати переконливо продемонстрували, що
високий систолічний АТ (САТ) прямо корелює з ризиком когнітивних порушень (КП) у людей похилого віку. ПідвищенняСАТ на кожні 10 мм рт. ст.
збільшує ризик помірнихКП на 7%, тяжких - на 9% (Launer L.J. et al., 2000).
Метою нашого дослідження було діагностувати та оцінити КП у пацієнтів похилого віку з ІСАГ.
Матеріали та методи дослідження. До основної групи увійшло 89
пацієнтів з ІСАГ (71,2±4,5) років. З них 45 чоловіків та 44 жінки
Ventricular dilatation in aging and dementia
No full textThe general objective of this thesis was to study the causes and consequences of ventricular dilatation in aging and dementia. For this purpose, we used ventricular shape analysis to study potential new MRI markers of cognitive decline in aging, subjective memory complaints, mild cognitive impairment and Alzheimer's Disease. In addition, we designed a volumetric measure that may objectively quantify the disproportionate ventricular dilatation that is characteristic of Normal Pressure Hydrocephalus (NPH). We investigated the value of this measure for the selection of candidates with NPH for ventricular shunting, studied its association with NPH-like symptoms in the general population and used the measure to explore a possible cardiovascular origin of cerebral ventricular dilatation.UBL - phd migration 201
Frailty and Risk of Cardiovascular Diseases in Older Persons: The Age, Gene/Environment Susceptibility-Reykjavik Study
No full textFrailty is a risk factor for cardiovascular diseases (CVD), but the studies available have not considered the presence of subclinical atherosclerotic disease as potential confounders. We investigated the association between frailty and the onset of CVD independently of subclinical atherosclerotic disease. For this reason, a sample of 3818 older participants participating in the Age, Gene/Environment Susceptibility-Reykjavik Study without CVD at baseline was followed for a median of 8.7 years. Frailty was defined as the presence of ≥3 among five Fried's criteria (unintentional weight loss, low physical activity level, weakness, exhaustion, and slow gait speed). Incident CVD was defined as onset of coronary artery disease, heart failure, stroke, and CVD-related mortality identified using hospital, medical, and death records. Subclinical atherosclerotic disease was evaluated as the maximum value of carotid intima media thickness, presence of carotid plaque (moderate or high), and total coronary calcifications (CACs). At baseline, frail participants (n = 300) were more frequently obese, diabetic, and had a greater presence of metabolic syndrome than the nonfrail (n = 3518). Frail participants also showed a higher presence of carotid plaques and CACs. Using a Cox's regression analysis, adjusted for clinical, biochemical, and subclinical atherosclerosis estimates, frailty increased the risk of CVD (hazard ratio [HR] = 1.35; 95% confidence interval [CI]: 1.05-1.74), with results stronger for women than men (HR = 1.51, p = 0.006 and 1.19, p = 0.44, respectively). Among Fried's criteria, exhaustion was the only criterion significantly associated with the onset of new CVD events (HR = 1.30; 95% CI: 1.00-1.73). In conclusion, frailty was associated with the onset of CVD in older people even after adjusting for subclinical atherosclerotic disease
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