1,278 research outputs found

    I precedenti giudiziali: prospettive romanistiche

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    Volume collettaneo a cura di VINCENTI U

    Cogan syndrome in children: early diagnosis and treatment is critical to prognosis

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    Am J Ophthalmol. 2004 Apr;137(4):757-8. Cogan syndrome in children: early diagnosis and treatment is critical to prognosis. Orsoni JG, Zavota L, Vincenti V, Pellistri I, Rama P. SourceOphthalmology Department, University of Parma, Parma, Italy. [email protected] Abstract PURPOSE: To present two cases of pediatric Cogan Syndrome and to highlight the differences between the adult and pediatric forms of the disease, as well as the importance of early diagnosis and treatment. DESIGN: Interventional case report. METHODS: Institutional setting. RESULTS: Corneal lesions were much more diffuse than those observed in adult Cogan syndrome. Immunosuppressive drug combination therapy successfully resolved systemic and ocular inflammation, but the involvement of the pupillary area caused permanent low vision in one case and amblyopia in the other. CONCLUSION: When chronic ocular inflammation is observed in association with sensory neural hearing loss and any systemic signs of autoimmune inflammation, a diagnosis of Cogan syndrome should be suspected. If immunosuppressive treatment is not initiated as soon as possible, permanent low vision and deafness can result

    Unravelling the anti-biofilm effects of plant derived compounds and nanoparticles at sub-lethal concentrations

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    The principal aim of this PhD project is to unravel the effects of bioactive-rich fractions obtained from halophytes and nanoparticles (NPs) for the development of innovative biocide-free, eco-sustainable strategies to counteract unwanted biofilms. Using sub-lethal doses of bio-inspired molecules and NPs we offer an elegant way to interfere with specific key-steps that orchestrate biofilm formation, disarming microorganisms without affecting their existence, sidestepping drug resistance and extending the efficacy of the current arsenal of antimicrobial agents. This PhD project will be carried out in collaboration with the Institute of Botany of the Leibniz University of Hannover (Germany)

    Surgical treatment of middle ear cholesteatoma in children with Down's syndrome

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    Otol Neurotol. 2005 Sep;26(5):1007-10. Surgical treatment of middle ear cholesteatoma in children with Down syndrome. Bacciu A, Pasanisi E, Vincenti V, Giordano D, Caruso A, Lauda L, Bacciu S. SourceDepartment of Otolaryngology, University of Parma, Parma, Italy. [email protected] Abstract OBJECTIVES: To report our personal experience in the surgical treatment of cholesteatoma in children with Down syndrome. STUDY DESIGN: Retrospective study. SETTING: Tertiary care otology and skull base centers. PATIENTS: Nine patients with Down syndrome were surgically treated for cholesteatoma. Two patients had bilateral disease, resulting in a total of 11 ears surgically treated. INTERVENTION: A canal-wall-up mastoidectomy was performed in two ears; in eight of the ears, a canal-wall-down mastoidectomy was carried out and a modified Bondy procedure was performed in one ear. RESULTS: Residual cholesteatoma was found in one ear after the canal-wall-up mastoidectomy and recurrent cholesteatoma developed in another ear, also after canal-wall-up mastoidectomy. The recurrence required conversion to canal-wall-down mastoidectomy. One patient developed a perforation of the neotympanic membrane that had to be revised. CONCLUSIONS: Cholesteatoma in children with Down syndrome is a challenging entity for the otologic surgeon. Otolaryngologists should always suspect a cholesteatoma in each child with Down syndrome presenting warning symptoms such as otorrhea and hearing loss. If there is any doubt on inspection, further imaging studies (high-resolution computed tomography) are necessary. To the best of our knowledge, the current study is the first report to document the surgical treatment of cholesteatoma in subjects with Down syndrome. PMID: 16151350 [PubMed - indexed for MEDLINE

    Between archaeology and law. 5. The first king (TRA ARCHEOLOGIA E DIRITTO. 5. IL PRIMO RE)

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    The author considers and connects two passages, one by Ennius, and the other by the jurist Pomponius. It would appear that Romulus would not have been the first king, but the first to give order to the Roman community. An order whose archetype had been traced on the ground as the perimeter of the primitive settlement. Ennius would confirm this by reporting that the first king would have reigned over a square: it would be the «Roma quadrata», which can be credibly located on the plateau of the Germalus
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