837 research outputs found
Strategic developments in collection storage
No full textIntervention au 34e congrès LIBER qui s\u27est tenu à Groningue aux Pays-Pas du 6 au 9 juillet 2005.
Les innovations en matière de conservation constituèrent un temps fort de ce congrès. Helen Shenton présente le projet de nouvelle bibliothèque-dépôt de la British Library qui a été programmée à la suite d\u27une étude de marché et dont l\u27organisation sera calquée sur celle des entreprises de logistique industrielle
Histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa
No full textThe present study was designed to explore the expression and distribution of histamine H3 and H4
receptors within the rat gastric fundus by immunohistochemistry using our unique immunological
probes. Groups of rats were either fed ad libitum or fasted for 24h before the sacrifice. Tissue
samples from the fundic region of the stomach were removed, fixed and processed for
immunohistochemistry, using our validated anti-H3 (349-358) and anti–H4 (374-390) antibodies.
The results showed that cells immunoreactive for H3R and H4R are located in the fundic epithelium.
The vast majority of H3R immunopositive cells occupied the lower half of the glands, and were
absent in the superficial portion. Their number per gland was 5.38 ± 0.19 in freely fed rats and 3.21
± 0.40 in fasted rats. Conversely, cells immunoreactive for H4R were dispersed throughout the
glands. Their number per gland was 0.75 ± 0.03 in fed rats and 0.90 ± 0.05 in fasted rats. Double
immunostaining revealed that the H3R is not colocalized with the H4R, while both H3R and H4R
positive cells were immunoreactive for chromogranin A, suggesting that these immunopositive cells
are endocrine cells. Because five different endocrine cell types have been identified in the rat fundic
epithelium, we used double immunostaining to identify the cell types expressing H3R and H4R,
respectively. Approximately 90% of cells positive for H3R were also immunoreactive for histidine
decarboxylase, demonstrating that the H3R is located on ECL cells. Cells positive for H4R were
immunoreactive for ghrelin, originating from A-like cells.
These findings may imply that histamine, via a balanced interaction with H3R and H4R expressed
on ECL and A-like cells respectively, regulates not only acid secretion and mucosal protection but
could also have a role in feeding behaviour and growth hormone release
Immunolocalization of histamine H3 receptors on endocrine cells in the rat gastrointestinal tract
No full textThe histamine H3 receptor (H3R) has been identified in the gastrointestinal tract of the rat by immunohistochemistry, using the first validated anti-H3 receptor antibody. Immunoreactivity to H3R was exclusively localized to the endocrine cells scattered in the gastrointestinal mucosa, with positive cells being prominently abundant in the gastric fundus, while they were rarely found in the other regions. In the fundus, positive cells were distributed in the lower half of the mucosa and their number significantly decreased after a 24 h-fasting period. Double-labeling studies were undertaken to identify the H3R-immunoreactive cell types in the fundic and antral mucosa. The H3R-immunoreactive cells were positive for chromogranin A. In the fundus, approximately 90% of cells positive to H3R were also positive to the histamine-forming enzyme, histidine decarboxylase. None of the cells expressing H3R displayed immunoreactivity for gastrin, somatostatin or ghrelin. Location, the influence of food deprivation and colocalization with histidine decarboxylase indicate that H3R positive cells correspond to the enterochromaffin-like cells (ECL)
Condensation Risk – Impact of Improvements to Part L and Robust Details on Part C -Interim report number 7: Final report on project fieldwork
No full textThis report sets out, in draft1, the results of the fieldwork phase of research into the impacts of the 2002 revisions to Part L of the building regulations (Approved Document L1 - DTLR, 2001), and the adoption of Robust Details (RDs - DEFRA 2001) on the extent of condensation risk in the construction of dwellings (Oreszczyn and Bell, 2003). The objective of the fieldwork was to explore the practical application of the revised Part L and its associated robust details by housing developers. This was done through a qualitative evaluation of the design and construction of 16 housing schemes designed in accordance with the revised part L and making use of robust details2. The results of the analysis are to be used to enable condensation modelling that takes into account not only the guidance of robust details but also the way in which construction details were actually designed and, perhaps more importantly, constructed. To this end the report identifies 7 areas of construction detailing (yielding some 15 separate detail models) that are to be included in the condensation modelling phase of the project
sj-docx-2-rsh-10.1177_17579139221103178 – Supplemental material for Exploring the mental health effects of Universal Credit: a journey of co-production
No full textSupplemental material, sj-docx-2-rsh-10.1177_17579139221103178 for Exploring the mental health effects of Universal Credit: a journey of co-production by M Cheetham, PJ Atkinson, M Gibson, SV Katikireddi, S Moffatt, S Morris, L Munford, F Shenton, S Wickham and P Craig in Perspectives in Public Health</p
sj-docx-1-rsh-10.1177_17579139221103178 – Supplemental material for Exploring the mental health effects of Universal Credit: a journey of co-production
No full textSupplemental material, sj-docx-1-rsh-10.1177_17579139221103178 for Exploring the mental health effects of Universal Credit: a journey of co-production by M Cheetham, PJ Atkinson, M Gibson, SV Katikireddi, S Moffatt, S Morris, L Munford, F Shenton, S Wickham and P Craig in Perspectives in Public Health</p
Young people and the evaluation of information on the World Wide Web: Principles, practice and beliefs
No full textA recurrent theme in LIS literature is the tendency of young people not to evaluate rigorously the information with which they come into contact. Although many information literacy models stress the need to take a critical approach, the reality of behaviour is often very different. Recent research conducted in an English high school has explored the importance that teenagers attach to ten particular evaluative criteria. 149 youngsters contributed data via an online questionnaire. Participants felt that information on the Web should be current/topical, free from spelling and grammatical errors and easily verifiable elsewhere but authorship was much less of a priority to them. The findings are likely to be of special relevance to information literacy teachers who are defining priorities for their own programmes
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