1,721,068 research outputs found
Editorial: Crohn's disease: nutritional strategies to improve patient's quality of life
Full text linkProbabile ruolo delle parassitosi a penetrazione cutanea sulla trasmissione parenterale del virus dell'epatite B
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Il Rumore degli impianti di climatizzazione delle centrali telefoniche
No full textL'introduzione dei nuovi apparati digitali nelle centrali telefoniche ha comportato l'installazione di impianti di climatizzazione di notevole potenzialità che sono causa di rumore soprattutto in estate. La temperatura dei locali che ospitano le apparecchiature elettroniche deve essere mantenuta costantemente al di sotto di 20°C. Il Laboratorio di Acustica dell'Università di Perugia ha svolto un'indagine
sperimentale in circa 90 centrali telefoniche; le misure fonometriche effettuate in base alle modalità e tempi riportate nel D.P.C.M 1/3/91 hanno consentito di caratterizzare il rumore prodotto da ogni centrale e la conseguente modificazione del "clima acustico" del territorio circostante. Sono state elaborate analisi statistiche per la stima dell'impatto acustico di una centrale telefonica in fase di progetto a partire dalla potenza elettrica installata
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Progress in nonviral gene therapy for breast cancer and what comes next?
No full textIntroduction: The possibility of correcting defective genes and modulating gene expression through gene therapy has emerged as a promising treatment strategy for breast cancer. Furthermore, the relevance of tumor immune microenvironment in supporting the oncogenic process has paved the way for novel immunomodulatory applications of gene therapy. Areas covered: In this review, the authors describe the most relevant delivery systems, focusing on nonviral vectors, along with the description of the major approaches used to modify target cells, including gene transfer, RNA interference (RNAi), and epigenetic regulation. Furthermore, they highlight innovative therapeutic strategies and the application of gene therapy in clinical trials for breast cancer. Expert opinion: Gene therapy has the potential to impact breast cancer research. Further efforts are required to increase the clinical application of RNAi-based therapeutics, especially in combination with conventional treatments. Innovative strategies, including genome editing and stem cell-based systems, may contribute to translate gene therapy into clinical practice. Immune-based approaches have emerged as an attractive therapeutic opportunity for selected breast cancer patients. However, several challenges need to be addressed before considering gene therapy as an actual option for the treatment of breast cancer
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