1,721,446 research outputs found
Neuroprotection : a valuable goal in glaucoma management?
No full textGlaucoma is characterized by an accelerated loss of retinal ganglion cells, as a result of damage to optic nerve axons. One factor involved in the disease process is elevated intraocular pressure (IOP) and this is the current focus of therapies. However, up to 45% of patients experience glaucoma progression despite good IOP control and partly as a result, the treatment principle of direct neuroprotection has been developed, which consists of treating optic nerve degeneration in glaucoma independently of IOP lowering. Animal models have shown the potential of this approach but there are limited clinical trial data. Brimonidine and memantine currently show promise, in terms of efficacy and side effects, among the compounds entering clinical trials. Brimonidine has been shown to have a neuroprotective effect independent of IOP lowering In humans with glaucoma, and data from a large clinical trial are being analyzed. Memantine has shown neuroprotective effects in animal models of glaucoma, and data from a clinical trial in humans are awaited
P. Fogagnolo, P. Frezzotti, P. Mittica, M. Digiuni, R. Paderni, E. Vallenzasca, L. Rossetti
No full text
Cystoid macular edema following cataract surgery
No full textCystoid macular edema (CME) remains a troublesome problem after cataract surgery and other types of ocular surgical procedures. It is recognized as the most frequent cause of decreased vision in patients following cataract surgery. Although the disease was first described more than 40 years ago, its cause is unclear, and all available therapeutic interventions, mainly based on theories regarding the pathogenesis of the condition, are of doubtful effectiveness and are still far from being satisfactory. Most published literature on the incidence and treatment of CME consists of small, retrospective case series and cannot provide reliable answers as to whether a given factor or intervention is associated with the occurrence or outcome of the disease
A quality assessment of randomized control trials on medical treatment of open-angle glaucoma
No full textGlaucoma, cataracts, and corneal anomalies in children
No full textPapers we deemed relevant on the topics congenital and pediatric cataracts, glaucoma, and cornea have been reviewed. Concerning pediatric glaucoma, only a few articles have been published; except for one interesting paper about van Lohuizen syndrome, most of the emphasis is given to forms of glaucoma associated with anterior segment malformations and with secondary glaucomas following pediatric cataract surgery. Most of the articles reviewed here are about pediatric cataract and are mainly concerned with the debated question of treatment of pediatric aphakia; lensectomy with vitrectomy remains the most commonly used technique today for pediatric cataracts. Implantation of intraocular lenses is recommended for children over 3 years of age, especially for children with monolateral forms; epikeratoplasty using nonlyophilized tissue seems a promising alternative to implantation
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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