1,721,078 research outputs found
Suzanne L. Pucci : Diderot and a Poetics of Science. Coll. « Reading Plus ». 1986
No full textStenger Gerhardt. Suzanne L. Pucci : Diderot and a Poetics of Science. Coll. « Reading Plus ». 1986. In: Dix-huitième Siècle, n°23, 1991. Physiologie et médecine. pp. 528-529
Suzanne L. Pucci : Diderot and a Poetics of Science. Coll. « Reading Plus ». 1986
No full textStenger Gerhardt. Suzanne L. Pucci : Diderot and a Poetics of Science. Coll. « Reading Plus ». 1986. In: Dix-huitième Siècle, n°23, 1991. Physiologie et médecine. pp. 528-529
Suzanne L. Pucci, Diderot and a Poetics of Science, Peter Lang,1986
No full textChouillet Jacques. Suzanne L. Pucci, Diderot and a Poetics of Science, Peter Lang,1986. In: Recherches sur Diderot et sur l'Encyclopédie, n°4, 1988. pp. 162-163
CARATTERIZZAZIONE FARMACOLOGICA E FUNZIONALE DI NUOVI LIGANDI DEI RECETTORI COLINERGICI NICOTINICI NEURONALI CHE MODULANO IL RILASCIO DI DOPAMINA NELLA VIA MESOSTRIATALE, UNA VIA IMPORTANTE PER GLI EFFETTI COMPORTAMENTALI DELLA NICOTINA.
Full text linkThe α6β2∗ neuronal nicotinic acetylcholine receptor (nAChR) subtype expressed in the dopaminergic mesostriatal pathway mediates many behavioural effects of nicotine, and is selectively blocked by the small disulfide-rich α-conotoxins PIA and MII. Both share a "ω-shaped" topology but PIA bears a tail in the N-terminal region containing three amino acids [arginine (R), aspartic acid (D), and proline (P)]. We synthesised a group of PIA-related peptides in which R1 was mutated or the RDP motif was gradually removed. Binding and functional studies showed that the RDP sequence is essential for the activity of PIA on the native rat α6β2* subtype, with a major role played by residue R1. Molecular modelling studies showed that recognition of PIA by α6β2* nAChRs depends on a salt bridge between the guanidine group of R1 and the highly negatively charged D166-D167 residues located on the β2 subunit. The RDP sequence was then added to the N-terminus of MII; the resulting hybrid peptide (RDP-MII) showed an increased potency (5-fold) and affinity (13-fold) for α6β2* but not for α3β2* nAChRs. Furthermore, as docking studies indicated E11 as a potential key residue engendering a α6β2* vs. α3β2* selectivity, we prepared and tested the following E11 mutated MII analogues: MII[E11R] and RDP-MII[E11R]. The binding and functional profiles of the new peptides at native rat α6β2* receptor were comparable with those of their leads while potency and affinity for native and heterologously expressed α3β2* nAChRs were reduced. Consequently, MII[E11R] and RDP-MII[E11R] are potent and α6β2* vs. α3β2* selective antagonists
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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